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1997 Fiscal Year Final Research Report Summary

Fine deletion mapping in esophageal cancer by linkage mapping set

Research Project

Project/Area Number 08671479
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionIwate Medical University School of Medicine

Principal Investigator

ISHIDA Kaoru  Iwate Medical University School of Medicine, Medicine, Lecturer, 医学部, 講師 (70146041)

Co-Investigator(Kenkyū-buntansha) TAMURA Gen  Iwate Medical Universty School of Medicine, Medicine, Assistant, 医学部, 助手 (20207244)
Project Period (FY) 1996 – 1997
Keywordsesophageal cancer / Chromosome / Prognosis
Research Abstract

We investigated the deletion map on all chromosomes of esophageal cancers using linkage mapping set. Loss of heterozygosity on 3p, 5q, 6p, 6q, 9p, 9q, 17p, 17q, 18q, and 21q was over 40%. The most frequent LOH was confirmed on 17q25.1, in which was previously identified as the TOC (tylosis oesophageal cancer) locus, responsible for the pedigrees with the high risk of esophageal cancer. Unknown tumor suppressor qene may exsist on 17q25.1. Disease outcome of patients exhibiting imultaneous deletion of 5q, 9p, 17p was worse than in patients without them. Frequent deletion on 9q and mutation of the PTCH gene occured in basaloid cell carcinomas. Homozygous deletion and de novo methylation of the p16/CDKN2 gene were observed in half of esophageal cancer patients, who exhibited wores prognoses.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Maesawa C, et al.: "MAD-velatel genes on 18q21.1, Smad2and Smad4,are alteved interqueutly in esophaseal squamaus cell carcinoma" Jpn J Cancer Res. 88(4). 340-343 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwaya T, et al.: "Esophageal carcinosarcoma: a genetic analysis" Gastroenterdogy. 113(3). 973-977 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maesawa C et al.: "Mutation in the Human Holmologue of the Drusophila Patched Gene in Esophageal Squamous cell Carcinoma" Genes Chromosome Caucer. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwaya et al.: "Deletioon of minimal region of the tylosis oesophageal cancer (toc) locus on chromosonp 17q 25. 1, in Sporadir esophageal cancer" Gastroenterology. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogasawara S., et al.: "Common deleted region on the long arm of chromosome in esophageal carcinoma" Gstroenterology. 110. 52-57 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maesawa C., et al.: "Loss of heterozygosity at the DCC gene locus is not crucial for the acquisition of metastatic potential oesophageal squamous cell carcinoma" Eur J Cancer. 32A. 896-898 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maesawa C., et al.: "Inactivation of CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma" Cancer Res.88. 340-343 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwaya T., et al: "Esophageal carcinosarcoma : A genetic analysis" Gastroenterology. 113. 937-977

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maesawa C., et al: "MAD-related genes 18q21.1, Smad2 and Smad 4, are altered infrequently in esophageal squamous cell carcinoma" Jpn J Cancer Res. 88. 340-343 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maesawa C., et al: "Mutations in the human homologue of the Drosophila patched gene in esophageal squamous cell carcinoma" Genes Chromosomes Cancer. 21. 276-279 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwaya T., et al: "Deletion of minimal region of the tylosis oesophageal cancer (TOC) locus on chromosome 17q25.1 in sporadic esophageal cancer" Gastroenterology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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