1997 Fiscal Year Final Research Report Summary
Chemoprevention of hamster pancreatic carcinogenesis
| Project/Area Number |
08671497
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | KAWASAKI MEDICAL SCHOOL |
|---|
Principal Investigator |
IWAMOTO Sueharu Kawasaki Medical School Surgery, Assistant Professor, 医学部, 講師 (60168599)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IMAI Hiroyuki Kawasaki Medical School Surgery, Assistant Professor, 医学部, 講師 (30148712)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Keywords | pancreatic carcinogenesis / hamster / chemoprevention / beta-carotene / palm carotene / green tea polyphenol / alpha-carotene |
|---|
| Research Abstract |
The effect of alpha-carotene, beta-carotene, palm carotene and green tea polyphenols (GTP) on the progression stage of pancreatic carcinogenesis after rapid production of ductal lesions were studied in Syrian hamsters. Dose threshold inhibitory effects were noted for beta-carotene, 25 ppm and palm caratene, 40 ppm which includes 25 ppm beta-carotene reducing the numbers of putative preneoplastic lesions of duct epithelial hyperplasia, atypical hyperplasia, as well as carcinoma in situ and invasive carcinomas. GTP at deses of 500 and 5000 ppm, but not 100 ppm, also significantly decreased the numbers of hyperplasia and total duct lesions. Combined administration of 40 ppm palm carotene and 50 ppm GTP similarly inhibited the lesion development. alpha-Carotene, however, did not affect pancreatic carcinogenesis. These results suggest that chemopreventive effects are exerted by beta-carotene and GTP above critical doses and that combined administration of palm carotene and GTP might be a candidate chemoprevention strategy for pancreatic cancer in man.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Publications] T.Tsunoda, Y.Yamamoto, M.Kimoto, H.Imai, S.Iwamoto, S.Kawasaki, K.Kawashima, Y.Tadaoka, T.Majima, E.Onuma, K.Iki, T.Kubozoe, T.Eto: "Topics, Staging and treatment for patients with pancreatic cancer. How small is an early pancreatic cancer?" J.Hep.Bil.Panc.Surg.(in press). (1998)
Description
「研究成果報告書概要(欧文)」より
