1997 Fiscal Year Final Research Report Summary
Induction of cytotoxic T lyphocytes (CTLs) recognized hepatocellular carcinoma (HCC) from tumor-infiltrating lymphocytes of HCC and identification of the tumor-rejection antigen genes of HCC.
| Project/Area Number |
08671500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kurume University |
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Principal Investigator |
SAITSU Hideki Kurume Univ., Sch.of Med., Assist. Prof., 医学部, 講師 (60186921)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Yasuhisa Kurume Univ., Sch.of Med., Instructor, 医学部, 助手 (90268847)
NAKAO Masanobu Kurume Univ., Sch.of Med., Instructor, 医学部, 助手 (40258447)
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| Project Period (FY) |
1996 – 1997
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| Keywords | HCC / CTL / MHC-nonrestriction / tumor-rejection antgens |
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| Research Abstract |
We investigatet T Cell immunity against hepatocellular carcioma (HCC), and showed that both peripheral blood mononuclear cells (PBMC) and tumor-infiltrating lymphocytes (TIL) incubated with ingterleukin-2 alone displayd HHLA-nonrestricted but hepatic cancer-specific cytotoxicity in a majority of parients with HCC.Namely, they lysed both HCC and cholagiocellular carcinomas in an HLA-nonrestricted manner, but not any tumors with the other histological types tested, normal hepatocytes or the cells transfected with Hepatitis C virus or MUCl gene. These CTL lines and clones were phenotypically CD3^+CD4^+CD8^-. These unique CTL could play important riles in T cell immunity against HCC.
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Research Products
(16 results)
