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1997 Fiscal Year Final Research Report Summary

Estimation of edema by diffusion-weighted magnetic resonance imaging in experimental traumatic brain injury

Research Project

Project/Area Number 08671564
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionCHIBA UNlVERSITY

Principal Investigator

YAMAKAMI Iwao  Chiba University School of medicine, Asst Prof, 医学部, 講師 (90241968)

Co-Investigator(Kenkyū-buntansha) KUBOTA Motoo  Chiba University Hospital : Res.Assoc, 医学部, 助手 (10225211)
IKEHIRA Hiroo  Chiba University Hosptal, ASSOC : Prof, 医学部, 講師 (50150313)
KITAHARA Hiroshi  Chiba University Hospital : Prof, 医学部, 教授 (30114268)
YAMAURA Akira  Chiba University School of medicine : Prof, 医学部, 教授 (40009717)
Project Period (FY) 1996 – 1997
Keywordsfluid percusson injury / brain edema / MRI / blood brain barrier
Research Abstract

The objective of this study was to use diffusion-weighted magnetic resonance imaging to help detect the dynamics of brain edema that develops after experimental brain injury and brain injury coupled with decompressive craniectomy.
(materials and methods)
Fluid percussion brain injury was induced in sixty adult Wister rats.After injury we monitored the brain edema by using T1, T2 weighted imaging and diffusion-weighted magnetic resonance imaging. These MR images were compared with pathological findings
(Results)
The information obtained by diffusion-weighted magnetic resonance imaging at acute phase of brain injury (30min after injury) reflected the damage of blood brain barrier observed by pathological findings using horse-radish peroxidase. At acute phase of brain injury diffusion-weighted magnetic resonance imaging provides us useful information about the damage of blood brain barrier.

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Published: 1999-03-16  

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