• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1998 Fiscal Year Final Research Report Summary

Neurotrophic Effects of Cytokine-activated Astrocytes.-Basic research for Elucidation of Interaction between Neuron and Glia, and Restoration of Damaged Neuronal Function-

Research Project

Project/Area Number 08671615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKEIO UNIVERSITY

Principal Investigator

YOSHIDA Kazunari  Keio University School of Medicine, Department of Neurosurgery, Assistant Professor, 医学部, 講師 (70166940)

Co-Investigator(Kenkyū-buntansha) ISHIMORI Hisatsugu  Keio University School of Medicine, Department of Neurosurgery, Assistant, 医学部, 助手 (30286489)
SHIMAZAKI Kenji  Keio University School of Medicine, Department of Neurosurgery, Assistant, 医学部, 助手 (00265836)
KAGAMI Hiroshi  Keio University School of Medicine, Department of Neurosurgery, Assistant, 医学部, 助手 (80255471)
SASAKI Hikaru  Keio University School of Medicine, Department of Neurosurgery, Assistant, 医学部, 助手 (70245512)
INABA Makoto  Keio University School of Medicine, Department of Neurosurgery, Assistant, 医学部, 助手 (00245507)
Project Period (FY) 1996 – 1998
Keywordscytokine / neuron / astrocyte / neurotrophic factor / cell adhesion molecule
Research Abstract

We have demonstrated that production and secretion of neurotrophic factors such as nerve growth factor (NGF) from astrocytes was enhanced by cytokines such as fibroblast growth factor(FGF), interleukin-1beta(IL-1beta), tumor necrosis factor-alpha(TNF-alpha), epidermal growth factor(EGF), transforming growth factor-beta1(TGF-beta1), which are likely to be present in the brain following injury.
We have demonstrated new knowledge mentioned below, from 1996- to 1998.
1. IL-1beta, TNF-alpha and EGF induced selective increase of high-molecular-weight bFGF isoforms in cultured rat hippocampal astrocytes.
2. IL-1beta and TNF-alpha co-operatively enhanced a novel trophic activity of astrocytes for pontine cholinergic neurons.
3. TGF-beta1 enhanced expression of NCAM in cultured rat hippocampal astrocytes.
4. Hepatocyte growth factor(HGF) receptor, c-Met was expressed in cultured rat hippocampal astrocytes. Cytokines enhanced expression of c-Met protein in cultured rat hippocampal astrocytes.

  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Kamiguchi H., Yoshida K., et al.: "Cytokine-induced selective increase of high molecular weight-bFGF isoforms and their subcellular kinetics in cultured rat hippocampal astrocytes." Neurochemical Research. 21. 701-706 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inaba M., Yoshida K., Shimazaki K., et al.: "Modulation of NCAM expression in cultured astrocytes and neurons by cytokines." Restorative Neurology and Neuroscience. 10. 174 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshida K., Toya S.: "Neurotrophic activity in cytokine-activated astrocytes" Keio J Med. 46(2). 55-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimazaki K., Inaba M., Yoshida K., et al.: "Regulation of membranous proteins expression by cytokines in cultured rat hippocampal astrocytes." Society for Neuroscience Abstracts. 23. 883 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimazaki K., Yoshida K., Hirose Y., et al.: "Cytokines regulate Met protein expression in cultured rat hippocampal astrocytes." Society for Neuroscience Abstracts. 24. 1540 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimazaki K., Yoshida K., Sasaki H., et al.: "Regulation of c-Met protein expression by cytokines in cultured rat hippocampal astrocytes." Restorative Neurology and Neuroscience. 13. 229 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamiguchi H., Yoshida K., Wakamoto H., Inaba M., Sasaki H., Otani M.and Toya S.: "Cytokine-induced selective increase of high-molecular-weight bFGF isoforms and their subcellular kinetics in cultured rat hippocampal astrocytes" Neurochemical Research. 21. 701-706 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamiguchi H., Yoshida K., Inaba M., Sasaki H., Otani M.and Toya S.: "Interleukin-1beta and tumor necrosis factor-alpha co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neuron in vitro." Restorative Neurology and Neuroscience. 10. 43-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimazaki K., Kamiguchi H., Yoshida K., Inaba M., Sasaki H., Otani M., Toya S.and Kawase T.: "Effects of cytokines on the expression of bFGF isoforms and subcellular localization in cultured astrocytes." Restorative Neurology and Neuroscienc. 10. 170 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kagami H., Yoshida K., Wakamoto H., Shimazaki K., Sasaki H., Inaba M., Awaya A., Otani M., Toya S.and Kawase T.: "A synthesized pyrimidine compound, MS-818 promotes FGF-induced cellular proliferation of rat schwannoma cell RN2 and human glioma cell T98G." Restorative Neurology and Neuroscience. 10. 173 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inaba M., Yoshida K., Sasaki H., Kamiguchi H., Shimazaki K., Otani M., Toya S.and Kawase T.: "Modulation of NCAM expression in cultured astrocytes and neurons by cytokines." Restorative Neurology and Neuroscience. 10. 174 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamiguchi H., Yoshida K., Shimazaki K., Inaba M., Sasaki H., Otani M.and Toya S.: "Cytokine-induced selective increase of high molecular weight-bFGF isoforms and their subcellular kinetics in cultured rat hippocampal astrocytes." Society for Neuroscience Abstracts. 22. 549 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki H., Yoshida K., Inaba M., Hoshi M., Kamiguchi H., Otani M., Toya S.and Kawase T.: "Expression of neural cell adhesion molecule (NCAM) in astrocytic tumors." Society for Neuroscience Abstracts. 22. 1982 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida k.and Toya S.: "Neurotrophic activity in cytokine-activated astrocytes." Keio J Med. 46(2). 55-60 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kagami H., Yoshida K., Wakamoto H., Kamiguchi H., Sasaki H., Inaba M., Shimazaki K.and Kawase T.: "Biological activity of acidic fibroblast growth factor expressed in human schwannoma." Restorative Neurology and Neuroscience. 11. 233 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inaba M., Yoshida K., Sasaki H., Kagami H., Shimazaki K., Otani M.and Kawase T.: "Expression of NCAM and polysialic moiety in cultured neurons." Restorative Neurology and Neuroscience. 11. 234-235 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimazaki K., Inaba M., Hirose Y., Yoshida K., Kagami H., Sasaki H.and Kawase T.: "Regulation of membranous proteins expression by cytokines in cultured rat hippocampal astrocytes." Society for Neuroscience. 23 (Abstracts). 883 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kagami H., Yoshida K., Wakamoto H., Sasaki H., Inaba M., Shimazaki K.and Kawase T.: "Expression of acidic fibroblast growth factor in human schwannomas and its biological activities." Society for Neuroscience. 23 (Abstracts). 884 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki H., Yoshida K., Inaba M., Ikeda E., Kagami H., Shimazaki K., Kondo A., Otani M.and Kawase T.: "Expression of the neural adhesion molecule (NCAM) in the astrocytic tumors : an inverse correlation with malignancy." Society for Neuroscience. 23 (Abstracts). 2446 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimazaki K., Yoshida K., Sasaki H., Kagami H., Kondo A., Ishimori H.and Kawase T.: "Regulation of c-Met protein expression by cytokines in cultured rat hippocampal astrocytes." Restorative Neurology and Neuroscience. 13. 229 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimazaki K., Yoshida K., Hirose Y., Ishimori H., Kondo A., Kagami H., Sasaki H.and Kawase T.: "Cytokines regulate Met protein expression in cultured rat hippocampal astrocytes." Society for Neuroscience. 24 (Abstracts). 1540 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-12-08  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi