1997 Fiscal Year Final Research Report Summary
Early detection of selective neuronal death by diffusion-weighted spectroscopic MR imaging
| Project/Area Number |
08671622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Meiji University of Oriental Medicine |
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Principal Investigator |
EBISU Toshihiko Meiji University of Oriental Medicine, Department of Neurosurgery, Associate Professor, 鍼灸学部, 助教授 (40278510)
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| Co-Investigator(Kenkyū-buntansha) |
NARUSE Shoji Kyoto Prefectural University of Medicine, Department of Radiology, Associate Pro, 医学部, 助教授 (50106407)
UMEDA Masahiro Meiji University of Oriental Medicine, Department of Neurosurgery, Assistant pro, 鍼灸学部, 講師 (60223608)
TANAKA Chuzo Meiji University of Oriental Medicine, Department of Neurosurgery, Professor, 鍼灸学部, 教授 (80163541)
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| Project Period (FY) |
1996 – 1997
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| Keywords | diffusion / spectroscopic imaging / metabolite / N-acetyl aspartate / neuronal death / ischemia / echo planar imaging |
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| Research Abstract |
1 Using 4.7 T experimental MR imager, we successfully obtained the diffusion-weighted spectroscopic imaging of N-acetyl aspartate (NAA) in the rat brain. In addition, there was a trend that apparent diffusion coefficient of NAA was decreased in the ischemic region after middle cerebral artery occlusion of rats. Considering NAA has been identified only in neurons, our finding could indicate that diffusion-weighted spectroscopic imaging of NAA is a specific and early marker of neuronal death.
2 For future clinical application of diffusion-weighted spectroscopic imaging of metabolites, we applied echo planar imaging (EPI) technique to diffusion-weighted imaging (DWI) of water using clinical MR imager. The ultrafast capability of EPI without any motion artifacts made the DWI measurement practical as a routine clinical examination. Using this technique, we reported that the DWI was a promising technique for early detection of cerebral infarction, diagnosis of brain abscess, and discrimination between cerebral infarction and deep white matter hyperintensity. In addition, we also reported that the isotropic diffusion-weighted imaging, trace imaging of diffusion tensor, was a useful in discriminating between diffusion-weighted hyperintensity of acute infarction and hyperintensity due to anisotropic effect of normal white matter.
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