1998 Fiscal Year Final Research Report Summary
An Experimental Study of the Hybrid Bone with Vascularized Periosteum
| Project/Area Number |
08671683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical Univ. |
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Principal Investigator |
YAJIMA Hiroshi Nara Medical Univ., Orthop.Surg., Lecturer, 医学部, 講師 (20221640)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAI Susumu Nara Medical Univ., Orthop.Surg., Professor, 医学部, 教授 (10075088)
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| Project Period (FY) |
1996 – 1998
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| Keywords | hydroxyapatite ceramics / vascularized tissue transplantation / periosteum / osteogenesis / bone marrow cells |
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| Research Abstract |
1. We made a model of the vascularized artificial bone, combined the periosteumn with the hydroxyapatite ceramics. We evaluated that the vascularized perioteum had an osteogenic capacity using Northen blotting.
2. We evaluated the postoperative neovascularization of the hydroxyapatite ceramics using microangiogram. It was no relationship between the vascular proliferation and the osteogenic capacity.
3. We made a new model of the vascularized artificial bone with bone marrow cells. We evaluated the osteogenic capacity histologically and biochemically. We found this model had an advantage of the rapid osteogenesis postoperatively.
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