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1997 Fiscal Year Final Research Report Summary

Dynorphin mRNA expression in dorsal horn neurons following traumatic spinal cord injury and the effect of neurotrophic factor

Research Project

Project/Area Number 08671700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHYOGO COLLEGE OF MEDICINE

Principal Investigator

TANIGUCHI Mutusmi  HYOGO COLLEGE OF MEDICINE,Assitant Professor, 医学部, 講師 (80188383)

Co-Investigator(Kenkyū-buntansha) NOGUCHI Koichi  Professor, 医学部, 教授 (10212127)
MARUO Soji  Professor, 医学部, 教授 (70068451)
Project Period (FY) 1996 – 1997
Keywordsspinal cord injury / dynorphin / in situ hybridization / neurotrophic factor
Research Abstract

The temporal and spatial distribution of preprodynorphin (PPD) mRNA expression in the injured rat spinal cord was examined by in situ hybridization. Rats were subjected to traumatic spinal cord injury at the T13 spinal segment using the weight drop method. Two double-labeling experiments revealed that increased PPD mRNA and dynorphin peptide expression were found exclusively in dorsal horn neurons. Neurons exhibiting an increase in the level of PPD mRNA were concentrated in the superficial laminae and the neck of dorsal horn within several spinal segments from the epicenter of the injury at 24h and 48h after injury. The number of neurons expressing PPD mRNA in each rat was significantly positively correlated with its motor dysfunction. These data supports the hypothesis that the dynorphin has a pathological role in secondary tissue damage and neurological dysfunction after spinal cord injury.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Tachibana, T. et al: "Dynorphin mRNA expression in dorsal horn neurons following traumatic spinal cord injury" J. Neurotrauma. (In Press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tachibana, T.et al: "Dynorphin mRNA expression in dorsal horn neurons following traumatic spinal cord injury ; temporal and spatial analysis using in situ hybridization" Journal of Neurotrauma. (In Press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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