1997 Fiscal Year Final Research Report Summary
RESEARCH ON NEUROTOXICITY OF NMDA ANTAGONIST AND THE EFFECTS OF ANESTHETICS ON THE NEUROTOXICITY
| Project/Area Number |
08671730
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | KANSAI MEDICAL UNIVERSITY (1997)
Kyoto University (1996) |
|---|
Principal Investigator |
NAKAO Shin-ichi KANSAI MEDICAL UNIVERSITY FACULTY OF MEDICINE LECTURER, 医学部, 講師 (10207714)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Keywords | ketamine / NMDA receptor / cingulate cortex / diazepam / halothane / propofol |
|---|
| Research Abstract |
Ketamine, a noncompetitive NMDA antagonist, has psychotomimetic activity (undesirable psychological reactions). Recent studies have shown that NMDA antagonists cause morphological damages in the cingulate cortex, which is suggested to be the responsible brain region for their psychotomimetic activity. In the present research, we have demonstrated that ketamine induced marked c-fos protein (c-Fos) expression, which is suggested to be a good metabolic marker, in the rat cingulate cortex. We also demonstrated that diazepam, halothane, and propofol at clinical doses inhibited the induction in a dose-dependent manner. These results provide the neuronal basis that these drugs prevent ketamine-induced psychotomimetic activity.
|
