1997 Fiscal Year Final Research Report Summary
Evaliation of Intraoperative Deliberate Mild Hypothermia during Neurosurgery
| Project/Area Number |
08671763
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nara Medical University |
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Principal Investigator |
KAWAGUCHI Masahiko Nara Medical University Department of Anesthesiology Instructor, 医学部, 助手 (60275328)
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| Co-Investigator(Kenkyū-buntansha) |
FURUYA Hitosh Nara Medical University Department of Anesthesiology Professor, 医学部, 教授 (70183598)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Hypothermia / Neurosurgery / Anesthesia / Temperature / Shivering |
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| Research Abstract |
Investigations in animals have demonstrated that mild degree of hypothermia (2-4ﾟC temperature reduction) are associated with substantial decrease in histologic damage in models of both global and focal cerebral ischemia. Therefore, we induced deliberate mild hypothermia in 130 patients who underwent intracranial operation using a water blanket and a convective device blanket. Anesthesia was maintained with nitrous oxide in oxygen, fentanyl and sevoflurane. The lowest temperature measured at the tympanic membrane during mild hypothermia was adjusted to 34.5ﾟC.Cooling and rewarming occurred at a rate of 1.3(]SY.+-。[)0.8ﾟC/h and 0.8(]SY.+-。[)0.3ﾟC/h, respectively. The cooling rate was mainly related to the weight to surface area ratio. Shivering was observed postoperatively in 30% and the occurrence of shivering was associated with age, weight, and core and peripheral temperature at the emergence from anesthesia. Intraoperative infusiion of prostaglandin E1 at a dose of 0.02 and 0.05mug/kg/h did not affect the changes in core temperature, although 0.05mug/kg/h of prostaglandin E1 increased the rewarming rate of rectal temperature. Intraoperative mild hypothermia did not affect the occurrence of postoperative wound infection and duration until the discharge compared with normothermia.
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