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1997 Fiscal Year Final Research Report Summary

Interaction between physiological activity and molecular form of natriuretic peptide

Research Project

Project/Area Number 08671768
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGunma University School of Medicine

Principal Investigator

GOTO Fumio  Gunma University School of Medicine Anesthesioligy and Reanimatology Professor, 医学部, 教授 (00092015)

Project Period (FY) 1996 – 1997
Keywordsnatriuretic peptide / renal function / cardiac function / eel
Research Abstract

A new type of natriuretic peptide with an extended C-terminal tail, ventricular natriuretic peptide (VNP), has been isolated from eel cardiac ventricles. We investigated the effect of eel VNP on the kidney and cardiovascular system, and compared these activity with those of mammalian peptides, hANP hBNP,in dogs. All peptides produced similar diuresis and natriuresis, but cardiac output and the left and right ventricular stroke works were decreased by hBNP,but hANP and eel VNP did not change these parameters. Systemic vascular resistance was increased by hBNP,but unaffected by other peptides.These results show that eel VNP has renal effects similar to ANP and BNP,but itelicits responses in the heart different from those of human natriuretic peptides in anesthetized dogs. We are now advancing peptide research to opioid system and pain control system in the central nervous sytem.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Fumio, Goto, et al: "Effect of eel ventricular natriuretic peptide on the kidney and cardiovascalar system in the day." Endocrine Journal. 43・2. 205-210 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumio, Goto, et al: "Renal and cardiac effects of eel ventricular natriuretic peptide." 11th World Congress of Anesthesiologists. (Abstract). 196- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumio, Goto, et al: "Hypertonic saline for intraoperative fluid therapy in transurethral resection of theprostate" Journal of Anesthesia. 10. 170-175 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumio, Goto, et al: "Production of Bicactive.Salmon Calcitonin From the Nonendocrine Cell Lines COS-7 andCHO." Peptides. 18・3. 439-444 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西川 光一, 後藤 文夫 他: "ハロセン抵抗性を示すショウジョウバエ変異株における神経筋シナプス伝達の解析" Journal of Anesthesia. (Abstract). 447- (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 亮, 後藤 文夫 他: "アデノウィルスベクターによるAMPA型グルタミン酸受容体チャネルのPC12細胞における機能発現" Journal of Anesthesia. (Abstract). 551- (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masayasu ARAI,Fumio GOTO,YoshioTAKEI: "Effect of Eel Ventricular Natriuretic Peptide on the Kidney and cardiovascular system in the Dog." Endc.J.43(2). 205-210 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SEIJI KATO,FUMIO GOTO: "Hypertonic saline for intraoperative fluid therapy in transurethral resection of the prostate." J Anesthesia. 10. 170-175 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KEN-ICHIRO TAKAHASHI,YUN-CAILIU,NAOKI HAYASHI,FUMIO GOTO,MIYUKI KATO,HIROYUKI KAWASHIMA,AND TOSHIYUKI TAKEUCHI: "Production of Bioactive Salmon Calcitonin From the Nonendocrine Lines COS-7 and CHO" Peptides. 18(3). 439-444 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumio GOTO,Masayasu Arai, YoshioTakei: "Renal and cardiac effects of ventricular natriuretic peptidde." 11^<th> world Congress of Anesthesiologists, April, 14-20, 1996 Sydency Abstract Book.196

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koichi Nishikawa, Fumio GOTO,Yoshiaki Kidokoro: "Analysis of Synaptic Transmission at the ncuromuscular junction of halothane-resistant mutants of Drosophila melanogaster" 44^<th> Annual Congress of Japan societyof Anesthesiology, April 23-25,1997. Niigata J Anesthesia 11sup.447

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sudo, Keisuke Tsuzuki, Fumio Goto, Seiji Ozawa: "Functional expression of AMPA-type glutamate receptor channcls in PC12 cells using adenoviral vectors." 44^<th> Annual Congress of japan Societyof Anesthesiology, April 23-25,1997. Niigata J Anesthesia 11sup.551

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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