1998 Fiscal Year Final Research Report Summary
Fever as a defense system of the body to surgical stress-Its physiological investigation and relationship to anesthesia
| Project/Area Number |
08671772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OZAKI Makoto Tokyo Women's Medical University, Anesthesiology, Associate Professor, 医学部, 助教授 (30160849)
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| Co-Investigator(Kenkyū-buntansha) |
ATARASHI Kenji Toyko Women's Medical University, Anesthesiology, Clinical Instructor, 医学部, 助手 (60184181)
NEGISHI Chiharu Toyko Women's Medical University, Anesthesiology, Clinical Instructor, 医学部, 助手 (40189361)
OZAKI Kyoko Toyko Women's Medical University, Anesthesiology, Clinical Instructor, 医学部, 助手 (00162561)
MORIOKA Nobutada Toyko Women's Medical University, Anesthesiology, Clinical Instructor (60256518)
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| Project Period (FY) |
1996 – 1998
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| Keywords | Anesthesia / Cytokines / Fever / Pyrogen / Temperature / Hyperthermia / Surgical Stress |
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| Research Abstract |
No matter how strictly the surgeons perform operation aseptically, 90% of the 1^<st> post-operative-day patients have significant fever. We found these post-operative fever had tight relationship with cytokines such as IL-1 (alpha, beta), IL-6, TNFalpha, INFalpha, MIP-1(alpha, beta). Surgical stress also provoke the release of various types of cytokines, especially IL-6 is known as sensitive cytokines to intensity of surgical stress and depth of anesthesia.
In this study, we investigated the interactions between fever and plasma cytokines changes during surgery and post-operatively. We also studied volunteers, each was given an intravenous injection of 50,000 IU/kg of interleukin-2 followed 2 hours later by 100,000 IU/kg. Volunteers were assigned randomly to three doses of desflurane to induce anesthesia : (1) 0.0 minimum alveolar concentration (MAC ; control), (2) 0.6 MAC and (3) 1.0 MAC.Desflurane-induced anesthesia produced a dose-dependent decrease in integrated and peak core temperatures after administration for pyrogen, with 1.0 MAC essentially obliterating fever. Anesthetic-induced inhibition of the pyrogenic response is therefore one reason that fever is an inconsistent clinical response to inflammation during surgery.
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