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1997 Fiscal Year Final Research Report Summary

Analysis of cancer related genes in the development of urogenital tumors

Research Project

Project/Area Number 08671840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKITASATO UNIVERSITY

Principal Investigator

UCHIDA Toyoaki  Kitasato Univ.School of Medicine, Assistant professor, 医学部, 講師 (70146489)

Co-Investigator(Kenkyū-buntansha) IWAMURA Masatsugu  Kitasato Univ.School of Medicine, Assistant professor, 医学部, 講師 (20176564)
EGAWA Shin  Kitasato Univ.School of Medicine, Assistant professor, 医学部, 講師 (60160347)
KOSHIDA Ken  Kitasato Univ.School of Medicine, Professor, 医学部, 教授 (40050380)
Project Period (FY) 1996 – 1997
KeywordsProstate cancer / Renal cell carcinoma / Bladder cancer / Oncogene / Tumor suppressor gene / Genomic instability / Androgen receptor
Research Abstract

We alnalysed various cancer related gene such as genomic instability using microsatellite markers, BRCA 1 gene and androgen receptor gene mutations in urogenital tumors including prostate cancer, renal cell carcinoma and bladder cancer.
Genomic instability was noted in l0-20 % of prostate cnacer, renal cell carcinoma, bladder and testicular tumors. Mutations of hMSH3, hMSH6, TGFbeta receptor type II and insulin like growth factor II receptor relating in the mismatch repair system were also identified in about 10% of mismatch repair phenotype+ (MMP+) samples but mutations of hMSH2 was not found in all cases. It may have a different pathway in development of MMP+ sporadic cancers in compare with hereditary nonpolyposis colorectal cancer. In addition, apoptotic related Bax gene was also showed mutation in MMP+ tumors.
Loss of heterozygosity (LOH) analysis on chromosome 17q21 including BRCA1 gene identified LOH in 4 of 24 (16.7%) sporadic prostate cancer and one case showed a mutation at exon 13 of the BRCA1 gene. His sister was died by ovarian cancer at 55 years old. BRCA1 gene is strongly correlated in the development in familial breast and ovarian cancer. It need further examination and longer follow up in male BRCA1 mutation carrier.
We could not any abnormality in a number of CAG repeats of the androgen receptor gene in control, benign prostaic hyperplasia and prostate cancer groups. However, one of 6 (16.7%) hormone independent prostate cancer showed a mutation of exon D of the AR gene but not of 5alpha-reductatse gene. Androgen receptor gene mutation may be related in the pathway of hormone resistance of prostate cancer.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Toyoaki Uchida: "Microsatellite instability in trasnsitional cell carcinoma of the urinary tract ans its relateionship to clinicopathological" Int.J.Cancer. 69. 142-145 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyoaki Uchida: "Mutation and microsatellite analysis of the androgen receptor gene in human prostate cancer." Int.J.Oncology. 11. 551-556 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shin Egawa: "The ratio of free to total serum prostate specific antigen and its use in differential diagnosis od prostate carcinoma in Japan." Cancer. 79. 90-98 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shin Egawa: "Deoxyribonucleic acid ploidy status as no basis for pathologic stage prediction in clinically resectable prostate cancer." Urology. 47. 548-552 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shin Egawa: "Significance of preoperative parameters for predicting tumor volume in nonpalpable prostate cancer." Jpn.J.Clin.Oncol.25. 356-361 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shin Egawa: "Risk of progression and dying of clinically locaized prostate cancer in Japan." World.J.Urology. 14. 363-369 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyoaki Uchida, Chunxi Wang, Chieki Wada, Masatsugu Iwamura, Shin Egawa and Ken Kshiba: "Microsatellite instability in transitional cell carcinoma of the urinary tract and its relationship to clinicopathological variables and smoking" Int J Cancer. 69. 142-145 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shin Egawa, Takefumi Saito, Masatsugu, Iwamura, Masahiro Aihara, Sadahito Kuwao, Toyoaki Uchida and Ken Koshiba: "Deoxyribonucleic acid ploidy status as no basis for pathologic stage prediction in clinically resectabl e prostate cancer" Urology. 47. 548-552 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shin Egawa, Takefumi Satoh, K.Suyama, Masaysugu Iwamura, Toyoaki Uchida and Ken Koshiba: "Risk of progression and dying of clinically localized prostate cancer in Japan" World J.Urology. 14. 363-369 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shin Egawa, Hideshige Koh, Makoto Ohori, Toyoaki Uchida, Sadahito Kuwao and Ken Koshiba: "Preoperative serum prostate-specific antigen, clinical stage and Gleason sum as for predicting final pathological stage in Japanese patients with prostate cancer" Jpn.J.Clin.Oncol.26. 438-444 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shin Egawa, Shigehiro Soh, Makoto Ohori, Toyoaki Uchida, Kazuo Cohji, Akio Fujii, Sadahito Kuwao and Ken Koshiba: "The ratio of free to total serum prostate specific antigen and its use in differential diagnosis of prostate carcinoma in Japan" Cancer. 79. 90-98 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyoaki Uchida, Chunxi Wang, Takefumi Sato, Masatoshi Muramoto, Masatsugu Iwamura, Shin Egawa and Ken Koshiba: "Mutation and microsatellite analysis of the androgen receptor gene in human prostate cancer. Int J Oncology, 11 : 551-556,1997." Int J Oncology. 11. 551-556 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shin Egawa, Masatsugu Iwamura, Toyoaki Uchida, Sadahito Kuwao and Ken Koshiba: "Impact of life extectancy and tumor doubling time on the clinical significance of prostate cancer in Japan" Jap.J.Clini.Oncol.27. 394-400 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyoaki Uchida, Chunxi Wang, Takefumi Sato, Makoto Ohori, Masatsugu lwamura, Shin Egawa and Ken Koshiba: "Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q21 in prostate cancer" Proceedings of the Seventh Workshop on Prostate Cancer. 41-44 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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