1997 Fiscal Year Final Research Report Summary
Clonality of prostatic ductal system by Analysis of Chimeric Mice
| Project/Area Number |
08671853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | AICHI CANCER CENTER |
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Principal Investigator |
SUGIMURA Yoshiki AICHI CANCER CENTER,RESEARCH FELLOW, 研究所, 研究員 (90179151)
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| Co-Investigator(Kenkyū-buntansha) |
TATEMATSU Masae DEPARTMETNT OF PATHOLOGY,AICHI CANCER CENTER,DIRECTOR, 病理学第一部, 部長 (70117836)
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| Project Period (FY) |
1996 – 1997
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| Keywords | prostate / chimeric mice / clonality / ductal system / C3H antigen / 前立腺腺管 / 泌尿生殖臓器 / 単クローン増殖 |
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| Research Abstract |
Though the first mammalian chimera was reported in 1961, suitable markers for different animal strains which are easily detectable in histological sections of all or most organs have not existed. Chimeric mice were prodeced having an excelent histological marker, the C3H antigen, which is strain specific and fulfillls all the criteria for an ideal strain-specific histolofgical marker. Using male and female C3H-Balb/c chimeric mice we have examinede pithelial cells of prostatic ductal systemaand their morphological units to determine whether individual organs and their morphological subunits are monoclonal or polyclonal in origin. Our preliminary results indicate that the epithelial prenchyma of prostate and seminal vesicle and their morphological subdivisions were derived from cells of borh input strains, indicating a polyclonal orgin for each organ and/or organ component. However, the immunoreactibility is unstabel, and we need further refininemnet of the mothodology for incvestigate chimeric organ.
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[Publications] Sugimura, Y., Foster, B.A., Hom, Y.K., Lipschutz, J.H., Rubin, J.S., Finch, P.W., Aaronson, S.A., Hayashi, N., Kawamura, J.and Cunha, G.R.: "Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate." Int J Dev.Biol. 40. 941-951 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Arima, K., Nakagawa, M., Yanagawa, M., Sugimura, Y., Tochigi, H., Kawamura, J.: "Prognostic factors of perpheral blood lymphocyte subsets in patiets with renal cell carcinoma." Urol Int. 57. 5-10 (1996)
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「研究成果報告書概要(欧文)」より
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