1998 Fiscal Year Final Research Report Summary
Identification of common allelic loss in chromosome 10q25-q26 in human endometrial cancer
| Project/Area Number |
08671861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Shinji Tohoku University, Department of Obstetrics and Gynecology, Lecturer, 医学部, 講師 (10142960)
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| Co-Investigator(Kenkyū-buntansha) |
KONNO Ryo Tohoku University, Department of Obstetrics and Gynecology, Lecturer, 医学部・附属病院, 講師 (70271905)
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| Project Period (FY) |
1996 – 1998
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| Keywords | endometrial cancer / chromosome 10q / tumor suppressor gene / PTEN |
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| Research Abstract |
Endometrial cancer is a common female pelvic malignancy whose incidence is increasing rapidly. However, molecular mechanisms of this disease are still to be elucidative. We performed the genome-wide screening of genetic alterations in endometrial cancer by means of CGH, FISH, and microsatellite analysis. Frequent allelic loss in chromosome l0q was found. PTENJ was cloned and mapped on 10q23.3 in 1997. Mutation analysis revealed frequent somatic mutations in sporadic endometrial cancers. However, our LOH analysis indicated that there is another region of common allelic loss in l0q. By extensive studies using microsatellite analysis and FISH, we narrowed down the commonly deleted region very small : the region was completely covered with three overlapping cosmid clones which was estimated to be less than 120-kb. Moreover, rare cutter cluster region was found within this region which suggested an existence of the CpG island.
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[Publications] Kong D,Suzuki A,Sou TT,Sakurada A,Kemp LW,Wakatsuki S,Yokoyama T,Yamakawa H,Furukawa T,Sato M,Ohuchi N,Sato S,Yio J,Wang S,Abraham JM,Souza RF,Smolinski KN,Meltzer SJ and Horii A.: "PTEN1 is frequently mutated in primary endometrial carcinomas." Nature Genetics.17. 143-144 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yamakawa H,Nagase S,Yuki M,Shiwaku HO,Furukawa T,Yoshinaga K,Soeda E,Hoshi M,Hayashi Y,Sato S,Yajima A and Horii A.: "Identification of a 100-kb region of common allelic loss on chromosome bands 10q25-q26 in human endometrial cancer." Genes Chromosome & Cancer.23. 74-77 (1998)
Description
「研究成果報告書概要(欧文)」より
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