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1998 Fiscal Year Final Research Report Summary

A STUDY FOR GENES PRESENTED DURING SEX MATURATION

Research Project

Project/Area Number 08671868
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionGUNMA UNIVERSITY

Principal Investigator

YAMADA Kiyohiko  Gunma University School of Medicine, Department of Obstetrics and Gynecology, Assistant Professor, 医学部, 講師 (00210443)

Project Period (FY) 1996 – 1998
Keywordsovarian follicle / preantral follicle / activin A / Follicle-stimulating Hormone / Transforming Growth Factor / Growth Hormone / follistatin / inhibin
Research Abstract

There are reports about the maturation and differentiation of the ovaries. However almost all those reports dealt with granulosa cells from estrogen primed animals. So far little was known about the maturation process of ovarian follicles. In this study we established an in vitro culture system of preantral follicles in the mouse.
We found that the preantral follicle from immature mice responded to Activin A, but not to Follicle-stimulating Hormone (FSH), and preantral follicles from mature mice responded to FSH, but not to Activin A (1). Then we found that Growth Hormone (GH) had a direct stimulatory effect on the preantral follicular growth (2), especially to the theca layers of the follicle. Transforming Growth Factor beta 1 (TGF beta 1) had also a stimulatory effect to the preantral follicle growth from mature mice, but not to those from immature mice. We also demonstrated that estrogen priming to the immature mice produced characteristic changes to preantral follicles that did not resemble to any other follicles from non primed control animals (in press). We have found the possibility that Activin A from larger follicles suppresses growth of the surrounding preantral follicles, and removal of this suppression causes de novo follicular growth (3).
We got interesting result about the character changes of preantral follicle from immature to mature type according to the responses to Activin A and FSH, direct effect of follistatin to the preantral follicles, changes of serum concentrations of inhibin A and inhibin B during sex maturation, and so on. They will be published in the future. We inquire further into problems about follicular growth in relation to leptin, neuropeptide Y and adrenal androgens and the onset of sex maturation.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Yokota H et al.: "Paradoxical Actin of Activin A on Folliculogenis in Immature and Adalt Mice" Endocrinology. 138・11. 4572-4576 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Liu.X.et al.: "Effects of Growth Hormone, Activin, and Follistatin on the Development of Preantral Follicle from Immature Female Mice" Endocrinology. 139・5. 2342-2347 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizunuma H.et al.: "Activin from Secondary Follicles Causes Small Preantral Follicles to Remain Dormant at the Resting Stage" Endocrinology. 140・1. 37-42 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hidemi Yokota et al.: "Paradoxical Action of Activin A on Folliculogenesis in Immature and Adult Mice" Endocrinology. 138-11. 4572-4576 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Xiaowei Liu et al.: "Effects of Growth Hormone, Activin, and Follistatin on the Development of Preantral Follicle from Immature Female Mice" Endocrinology. 139-5. 2342-2347 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideki Mizunuma et al.: "Activin from Secondary Follicles Causes Small Preantral Follicles to Remain Dormant at the Resting Stage" Endocrinology. 140-1. 37-42 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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