1997 Fiscal Year Final Research Report Summary
Regulation and physiological function of sulfation of lipids in uterine endometrium during implantation period
| Project/Area Number |
08671871
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | University of Tokyo |
|---|
Principal Investigator |
MOMOEDA Mikio University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部・附属病院, 助手 (50221627)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Keywords | endometrium / cholesterol sulfate / implantation / tropoblast / protease |
|---|
| Research Abstract |
As the basic research for the study of embryo implantation, we analyzed the changes in lipid components in the endometrium during the implantation period. Characteristic expression of cholesterol sulfate (CS) was observed in the rabbit endometrium during peri-implatation period. In present study, we found that cholesterol sulfotransferase was also activated during implantation period, suggesting that the enzyme upregulate the expression of CS. We succeeded to purify the cholesterol sulfotransferase, and are working on clonig the enzyme. As for the physiological function, we examined the effects of CS on trophoblast spreading in vitro and activity of proteases associated with the invasion of trophoblast. It was demonstrated that CS coated on the culture dish suppressed the trophoblast spreading and that CS inhibited the activity of plasmin among the various proteases. These results suggested that CS could regulate the invasion and growth of balstcyst at the implantation site.
|
-
-
-
-
-
[Publications] Momoeda, M., Yano, T., Tsutsumi, O., Cui, Y., Iwamori, M. and Taketani, Y.: "Hormone dependent sulfation of lipids in uterine endometrium."In vitro Biology of Sex Steroid Hormone Action (ed. by H. Kuramoto et al. Churchill Livingstone, Tokyo. 112-119 (1996)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Momoda, M., Tsutsumi, O., Morita, Y., Igarashi, T., Suenaga, A., Osuga, Y, Shiotsu, H., Yano, T. and Taketani, Y.: "Differential effect of exogenous human chorionic gonadotropin on progesterone production from normal or malfunctioning corpus luteum."Human Reproduction. 13. 1907-1911 (1998)
Description
「研究成果報告書概要(欧文)」より
-
-
