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1997 Fiscal Year Final Research Report Summary

Regulation and physiological function of sulfation of lipids in uterine endometrium during implantation period

Research Project

Project/Area Number 08671871
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Tokyo

Principal Investigator

MOMOEDA Mikio  University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部・附属病院, 助手 (50221627)

Project Period (FY) 1996 – 1997
Keywordsendometrium / cholesterol sulfate / implantation / tropoblast / protease
Research Abstract

As the basic research for the study of embryo implantation, we analyzed the changes in lipid components in the endometrium during the implantation period. Characteristic expression of cholesterol sulfate (CS) was observed in the rabbit endometrium during peri-implatation period. In present study, we found that cholesterol sulfotransferase was also activated during implantation period, suggesting that the enzyme upregulate the expression of CS. We succeeded to purify the cholesterol sulfotransferase, and are working on clonig the enzyme. As for the physiological function, we examined the effects of CS on trophoblast spreading in vitro and activity of proteases associated with the invasion of trophoblast. It was demonstrated that CS coated on the culture dish suppressed the trophoblast spreading and that CS inhibited the activity of plasmin among the various proteases. These results suggested that CS could regulate the invasion and growth of balstcyst at the implantation site.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Momoeda,M.,Yano,T.etal: "Hormone dependent sulfation of lipids in uterine endometrium"In Vitro Biology of Sex Steroid Hormone Action. 112-119 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Momoeda,M.,Tsutsumi,O.etal.: "Differentia effect of exogenous human chorionic gonadotropin on progesterone production from normal or malfunctioning corpus luteum"Human Reproduction. 13. 1907-1911 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 百枝幹雄・武谷雄二: "着床における子宮内膜硫酸化脂質の役割"産婦人科の世界. 51. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 百枝幹雄・武谷雄二: "子宮内膜制*機構in新女性医学大系12"中山書店. 401 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Momoeda, M., Yano, T., Tsutsumi, O., Cui, Y., Iwamori, M. and Taketani, Y.: "Hormone dependent sulfation of lipids in uterine endometrium."In vitro Biology of Sex Steroid Hormone Action (ed. by H. Kuramoto et al. Churchill Livingstone, Tokyo. 112-119 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Momoda, M., Tsutsumi, O., Morita, Y., Igarashi, T., Suenaga, A., Osuga, Y, Shiotsu, H., Yano, T. and Taketani, Y.: "Differential effect of exogenous human chorionic gonadotropin on progesterone production from normal or malfunctioning corpus luteum."Human Reproduction. 13. 1907-1911 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Momoeda, M. and Taketani, Y.: "The mechanism of endometrium shedding."Shin Josei Igaku Taikei. 12. 365-374 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Momoeda, M. and Taketani, Y.: "Physiological function of sulfated lipids in uterin endometrium during inplantation period."Sanfujinka no Sekai. 51. (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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