1998 Fiscal Year Final Research Report Summary
THE INHIBITORY EFFECT OF ADENOSINE ON PLATELET FUNCTION IN PREGNANCIES COMPLICATED BY PREECLAMPSIA.
| Project/Area Number |
08671938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
YONEYAMA Yoshio NIPPON MEDICAL SCHOOL OBSTETRICS AND GYNECOLOGY ASSISTANT PROFESSOR, 医学部, 講師 (00201096)
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| Project Period (FY) |
1996 – 1998
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| Keywords | adenosine / preeclampsia / platelet aggregation |
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| Research Abstract |
[PURPOSE]
The purpose of this study is to evaluate the relationship between the inhibitory effect of adenosine on platelet function in pregnancies complicated by preeclampsia.
[METHOD]
We mesured plasma adenosine cconcentration in normal and preeclamptic women, then evaluate the relationship between plasma adenosine concentration and platelet function.
[RESULTS]
Maternal plasma adenosine concentration in preeclamptic women was significantly higher than the respective values in normal pregnant women, and which was associated with inhibitory effect of platelet aggregation.
[CONCLUSION]
This study has suggested that plasma adenosine may play role in regulation of platelet function in pregnancies complicated by preeclampsia.
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