1997 Fiscal Year Final Research Report Summary
A study to develop homeostatic biomaterial
| Project/Area Number |
08672092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
INOUE Takashi TOKYO DENTAL COLLEGE,DEPARTMENT OF DENTISTRY,ASSISTANT PROFESSOR, 歯学部, 助教授 (20125008)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINARI Masao TOKYO DENTAL COLLEGE,DEPARTMENT OF DENTISTRY,ASSISTANT PROFESSOR, 歯学部, 助教授 (10085839)
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| Project Period (FY) |
1996 – 1997
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| Keywords | lmplant / biomaterial / adhesive resin / tissue interface / hydroxyapatite / immunohisitochemistry / in vitro / electron microscopy |
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| Research Abstract |
1 : A Study of implant-tissue interface
The peri-implant epithelium may have less hemidesmosomal attachment and maintain lower capacity to act as a proliferative defense mechanism than does the junctional epithelium. Cervicular fluid flow may help the low proliferative activity of the peri-implant epithelium.
With some implant types, an understanding of how early granulation and bone healing occurs following placement of the implant, and how healing can be influenced by the distance from the implant surface to core implant, is crucial to optimizing implant surface geometry.
Ultrastructurally, bone-titanium interface there are poorly mineralized layr consisting of delicate fibril-like structures or the slender cell layr through a thin amorphous zone (20-40nm). This amorphous zone was positive for uthenium red which has a high affinity for proteoglycans and this may be an essential for attachment between the slender cell layr poorly mineralized layr or mature bone and titanium.
2 : Develop homeostatic biomaterial
It is suggested that, after 4-META penetration into the pulp, most of the penetrated 4-META forms STHL at the surface area of pulp, and the residue penetrates deep into pulp tissue to form and immature polymer. The remaining unpolymerized MMA monomer, 4 META monomer, butanol, and boric acid reach the front edge of penetration. These phenomena might cause decrease of blood flow and may disturb the early stage of pulpal healing when 4-META is applied on the pulp.
From now on we will try to produce new material which produce much more thicker soft tissue hybrid layr.
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[Publications] Ayukawa, Y., Takeshita, F., lnoue, T.Yoshinari, M., Ohtsuka, Y., Murai, K., Shimono, M.Suetsugu, T.and Tanaka, T.: "An ultrastructural study of the bone-titanium interface using pure titanium-coated plastic and pure titanium rod implants." Acta Histochemica et Cytochemica. 29. 243-254 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Inoue, T., Takeda, T., C.Y.Lee., Abika, Y., Ayukawa, Y., Tanaka, T., Yoshinari, M., Shimono, M.: "Immunolocalization of proliferating cell nuclear antigen in the peri-implant epithelium" Bull Tokyo Dent.Coll.38 (3). 187-193 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Ayukawa, Y., Takeshita, F., Yoshinari, M., lnoue, T., Ohtsuka, Y., Shimono, M., Suetsugu, T.And Tanaka, T.: "An immunocytochemical study for lysosomal cathepsins B and D related to the intracellular degradation of titanium at the bone-titanium interface." J.Periodontol.69 (in press). (1998)
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「研究成果報告書概要(欧文)」より
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[Publications] Ayukawa, Y., Takeshita, F., Yoshinari, M., Inoue, T., Ohtsuka, Y., Shimono, M., Suetsugu, T.And Tanaka, T.: "an immunoelectron microscopic lacalization of noncollagenous bone proteins (osteocalcin and osteopontin) at the bone-titanium interface of rat tibiae." J.Biomed.Mater.Res. (in press). (1998)
Description
「研究成果報告書概要(欧文)」より
