1997 Fiscal Year Final Research Report Summary
The Roles of beta1 Integrin in Chondrogenesis
| Project/Area Number |
08672122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
ENOMOTO-IWAMOTO Motomi Osaka University, Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (80203644)
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| Project Period (FY) |
1996 – 1997
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| Keywords | beta1 integrin / chondrogenesis / fibronectin / cell aggregation / limb development |
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| Research Abstract |
The aim of this project is to investigate the roles of beta1 integrins in chondrogenesis. The following results were obtained.
(1) beta1 integrin subunit and sevrel alpha subunits including alpha1, alpha3, alpha5 and alphav were expressed in the cartilaginous regions of the developin limb, and the expression levels of these integirn subunits did not remarkedly changed during cartilage development.
(2) The disruption of beta1 integrin function stimulated chondrogenesis in limb bud cultures.
(3) The disruption of fibronectin signals stimulated chondrogenesis in limb bud cultures.
(4) The stimulation of chondrogenesis by the disruption of beta1 integrin signaling is mainly due to the stimulation of cell aggregation.
These findings suggest that the fibronectin signal through beta1 integrin negatively regulates the induction of chondrogenesis during limb development.
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[Publications] N.Kinto, M.Iwamoto, M.Enomoto-Iwamoto, S.Noji, H.Ohuchi, H.Yoshioka, H.Kataoka, Y.Wada, G.Yuhao, H.E.Takahashi, S.Yoshiki and A.Yamaguchi: "Fibroblasts expression Sonic hedgehog induce osteoblast differentiation nad ectopic bone formation" FEBS Lett.404. 319-323 (1997)
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