1997 Fiscal Year Final Research Report Summary
Application of Biphasic Calcium Phosphate (BCP) Granules as a Carrier for Bone Morphogenetic Protein
| Project/Area Number |
08672181
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ODA Shigeru Tokyo Med.& Dent.Univ., Fac.of Dent., Lecturer, 歯学部, 講師 (70160869)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Atsuhiro Tokyo Med.& Dent.Univ., Fac.of Dent., Instructor, 歯学部, 助手 (10242207)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Biphasic Calcium Phosphate / beta-tricalcium Phosphate / Hydroxyapatite / BMP / Bone Morphogenetic Protein / Ectopic Bone Formation / Rat |
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| Research Abstract |
Alloplasts have been used to facilitate the regeneration of the periodontal regeneration suffered from periodontal disease. We have developed bioabsorbable ceramics, which was called biphasic calcium phosphate (BCP) granules, for clinical use. Recently, there have been attempted to apply recombinant human bone morphogenetic proteins (rhBMPs) in medical and dental treatments.
The purpose of this study was to investigate the ectopic bone formation induced by BCP granules combined with rhBMP-2 in rat dorsum.
1) Ectopic bone formation by BCP combined with rhBMP-2 in the rat dorsum These results indicated that BCP combined with rhBMP-2 induced ectopic bone formation without additional carriers. Therefore, BCP granules alone can function as carriers for rhBMP-2 to induce bone formation.
2) Ectopic bone formation by three types of ceramics combined with rhBMP-2 in the rat dorsum
Biphasic Calcium Phosphate (BCP), beta-tricalcium phosphate (TCP) and hydroxyapatite (HAP) were used as carriers for rhBMP-2. These results showed that new bone formation was significantly greater in the BCP-BMP than in the TCP-BMP and the HAP-BMP.
3) Longitudinal observation (four days, one weeks, three weeks, twelve weeks postoperation) of ectopic bone formatin by BCP combined with rhBMP-2 in the rat dorsum
A large quantity of new bone was formed from 4 weeks after operation. Twelve weeks postsurgery, a large quantity of new bone has resided without resorption.
Consequently, BCP granules alone would be applicable as a carrier for rhBMP-2 in order to induce new bone formation.
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[Publications] OHNO,J., AOKI,A., YOSHINO,T., BANDO,K., ODA,S., WATANABE,H.and ISHIKAWA,I.: "The Effect of the Er : YAG Laser on the Tongue of Rat-Macroscopic and SEM Observation after Irradiation under Various Conditions Supposing the Side Effect of Mis-irradiation." Journal of Japanese Scociety for Laser Dentistry. Vol.7. 46-57 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] AOKI,A., YOSHINO,T., OHNO,J., BANDO,K., ODA,S., WATANABE,H.and ISHIKAWA,I.: "The Effects of Mis-irradiation of the Er : YAG Laser on Soft and Bone Tissues" 5th Congress of the International Society for Laser in Dentistry, Azaz B (ed.), Monduzzi Editore, Bologna. 27-32 (1996)
Description
「研究成果報告書概要(欧文)」より
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