• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1997 Fiscal Year Final Research Report Summary

Experimental studies on successive changes of the microvascular architecture during the period of bone healing in extracted sockets using human dura mater.

Research Project

Project/Area Number 08672271
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOsaka Dental University

Principal Investigator

SUWA Fumihiko  Osaka Dental University, Faculty of Dentistry, Professor, 歯学部, 教授 (30067178)

Co-Investigator(Kenkyū-buntansha) IKE Hiromi  Osaka Dental University, Faculty of Dentistry, Assistant, 歯学部, 助手 (30222855)
TODA Isumi  Osaka Dental University, Faculty of Dentistry, Assistant, 歯学部, 助手 (20197891)
TAKEMURA Akimichi  Osaka Dental University, Faculty of Dentistry, Recturer, 歯学部, 講師 (00155045)
Project Period (FY) 1996 – 1997
KeywordsGuided bone regeneration / Microvascularization / Osteogenesis / Repairing of wound / Dura Mater / Alveolar bone Augmentation
Research Abstract

It is necessary to control the absorption of alveolar bone after tooth extraction for prosthodontic treatment. The guided bone regeneration (GBR) method has been reported on the application to the extracted tooth socket, and how to use an absorbable membrane to reduce the patient's pain. This study investigated the contribution of human dura mater to microvascularization and osteogenetic changes in extracted sockets by SEM observation.
Materials and Methods
The upper incisors in Macaca fuscota were bilaterally extracted, and the human dura mater was applied and covered one of the sockets. The other side was the control. After application, the gingivoperiosteal flap was carefully sutured. At 1,2,4,6 and 8 weeks after postoperatively, microvascular casts prepared by the plastic injection method were examined by SEM.
At 1 week, both site sockets were filled with the newly-formed sinusoidal capillaries which elongated from the socket wall ; no bone formation was observed. At 2 weeks in the experimental site, the newly-formed microvascularization was denser than the control. At 4 weeks, the bottom half of the both site sockets were filled with newly-formed bone trabeculae, but in the experimental site, the new bone trabeculae was denser. At 6 weeks, the both site sockets were filled with new bone trabeculae. However, we observed a shallow concave at the top of each socket. At 8 weeks, in the experimental site, the extracted socket was filled with the new bone trabeculae, and the edge of the socket was flat. While in the control site, the shallow concave was still observable.
We conclude that the human dura mater contributes to the osseous healing of the socket left by extraction and prevents the absorption of alveolar bone.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Toda I, Kitayama N, Sugihara F, Suwa F, Oonishi H: "Alveolar ridge augmentation using α-TCP-collagen sponge" Bioceramics. 9. 887-891 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 戸田 伊紀、諏訪 文彦、杉原 富人、大西 啓靖: "生体材料による歯槽骨形成" 日本バイオマテリアル学会雑誌. 予稿集. 31 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 戸田 伊紀、北山 展弘、村岡 正規、杉原 富人、大西 啓靖、権田 悦通、諏訪 文彦: "抜歯窩の治癒過程における吸収性生体材料の応用" 日本バイオマテリアル学会雑誌. 予稿集. 93 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 戸田 伊紀、北山 展弘、村岡 正規、諏訪 文彦、権田 悦通、杉原 富人: "吸収性コラーゲン材の抜歯窩への応用" 歯科基礎医学会雑誌. 39(補冊). 446 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Suwa, I.Toda, H.IKE, A.TAKEMURA: "Alveolar Bone Augmentation Using Dura Mater" Journal of Dental Research. (掲載予定). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 諏訪 文彦、竹村 明道、戸田 伊紀、池 宏海: "ヒト脳硬膜を抜歯窩に用いた場合の骨修復と血管構築の変化に関する実験的研究" 日本口腔インプラント学会雑誌. (掲載予定). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toda I,Kitayama N,Sugihara F,Suwa F,Oonishi H: "Alveolar ridge augmentation using alpha-TCP-collagen sponge" Bioceramics. 9. 887-891 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toda I,Suwa F,Sugihara F,Oonishi H: "Augmentation with biomaterials for the alveolar bone." Japanese Society for Biomaterials, Abstracts of the 19th Annual Meeting. 31 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toda I,Kitayama N,Muraoka M,Sugihara F,Oonishi H,Gonnda Y,Suwa F: "Adsorbable Biomaterials Application to the Tooth Extracted Socket." Japanese Society for Biomaterials, Abstracts of the 19th Annual Meeting. 93 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toda I,Kitayama N,Muraoka M,Suwa F,Gonnda Y,Sugihara F: "Application of the absorbable collagen material to the tooth extracted socket." Japanese Journal of Oral Biology. 39 (suppl). 446 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F.Suwa, I.Toda, H.IKE,A.TAKEMURA: "Alveolar Bone Augmentation Using Dura Mater" Journal of Dental Research. (Journal is due out). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F.Suwa, A.TAKEMURA,I.Toda, H.IKE: "Experimental studies on successive changes of the microvascular architecture during the period of bone healing in extracted sockets using human dura mater." Journal of Japanese Society of Oral Implantology. (Journal is due out). (1998)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi