The Change of cytokines with autologous blood transfusion and appropriation of malignant tumor

1997 Fiscal Year Final Research Report Summary

• Project/Area Number: 08672335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: GOTOH Kinuko Showa university, school of dentistry : assistant professor, 歯学部, 講師 (70176262)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Hiroyoshi Showa university, school of dentistry : assistant, 歯学部, 助手 (10239949)
• Project Period (FY): 1996 – 1997
• Keywords: Autologous blood transfusion / Malignant tumor / IL-1beta / IL-6 / ACTH / Allogenic blood transfusion

Research Abstract

The conceptual basic for blood transfusion, autologous blood transfusion increases nonspecific innusnty, but allogenic blood transfusion decrease it. We measured cytokines, and studied the influence of autologous blood transfusion.
With appeal of informed concoct, 24 patients scheduled for oral surgery were enrolled in this study. They divided into 3 groups, one of group was useless of blood transfusion(it was boric 8 cases.) and next group were operated saggital split ramous cstectomy (SSRC). (In 4 cares used hemodilutional autotransfusion, and another 4 cases used autotransfusion.) The remain, malignant tumor groups, in 4 cases were received autulogous and allogenic blood transfusion, the other 4 cases were received antologous blood transfusion nly. All of them were measured IL-1B.IL-6. ACTH at preoperative, pot operative of one day. 7 day. And 10 day.
There were no siynifuant degres in IL-1B and ACTH in these divided 3 groups. In IL-6. increased malignant tuner that wed allergenic blood transfusion, and in SSRO . Antologous blood transfusion is better than henclilutind blood transfusion.