1997 Fiscal Year Final Research Report Summary
Synthesis of Tn and Sialyl Tn Antigen-Lipid A Analog Conjugate for Synthetic Vaccines
| Project/Area Number |
08672565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
医薬分子機能学
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IKEDA Kiyoshi University of Shizuoka, School of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 (40168125)
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| Project Period (FY) |
1996 – 1997
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| Keywords | synthetic vaccines / lipid A analogue / mitogenic activity / synthetic immunoad juvat / antitumor antigen / HIV antigen |
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| Research Abstract |
We synthesized the completely synthetic vaccines based on tumour- and HIV-associated carbohydrate and peptide antigens having N-tetradecanoyl L-seryl-beta-alanine-containing D-glucosamine derivatives structurally related to lipid A as efficient synthetic immunoadjvants. These synthetic vaccines showed potent immunogenic activities.
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