1997 Fiscal Year Final Research Report Summary
Effect of LPS fever in full-term pregnant rats on fetal brain.
| Project/Area Number |
08680016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
家政学
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| Research Institution | Hyogo University of Teacher Education |
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Principal Investigator |
IMAI Matumura Kyoto Dept.of Life and Health Sciences, Hyogo University of Teacher Education, Professor, 学校教育学部, 教授 (40173877)
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| Project Period (FY) |
1996 – 1997
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| Keywords | pregnant / fetus / c-fos / rat / fever / PGE_2 / COX-2 |
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| Research Abstract |
Using c-fos immunohistochemistory, I investigated whether LPS fever in full-term pregnant rat exerts any effects in fetal brain. I could not find LPS-induced c-fos positive cells in fetal rat brain. This might be due to the suppression of fever in full-term pregnant rat.
Therefor, I investigated the mechanism of the supprression of fever. In this case, hypothalamic response to PGE_2 was intact. However, PGE_2 increase in the CSF after intraperitoneal injection of LPS was significantly diminished compared to virgin rats. Furthermore, the number of cyclooxygenese-2-positive cells was decreased in the brain of full-term pregnant rats.
These results indicate that suppression of fever in full-term pregnant rats is due to the suppression of PGE_2 synthesis.
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