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1998 Fiscal Year Final Research Report Summary

Involvement of nutrition and endocrine in muscle and bone atrophy : Relationship with agin

Research Project

Project/Area Number 08680044
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 家政学
Research InstitutionCollege of Nagoya Women's University (1997-1998)
Nagoya Women's University (1996)

Principal Investigator

KAWANO Setsuko  College of Nagoya Women's Uhtversity, Professor, 教授 (40024640)

Co-Investigator(Kenkyū-buntansha) MURATA Yoshiharu  Nagoya University, Res.Inst.of Environ.Med., Prof., 環境医学研究所, 教授 (80174308)
Project Period (FY) 1996 – 1998
Keywordsrat / tail suspension / ovariectomy / estrogen / femur / antigravity muscle / deoxypridinoline / PTH
Research Abstract

Estrogen plays an important role in prevention of development of osteoporosis. Supplementation of estrogen to postmenopausal women attenuates loss of bone mass. However, it is not evident how estrogen plays a role in bone metabolism and how it modifies actions of other hormones and local factors in bone microenviroment. We have shown that tail-suspended rat is a suitable model for studying muscle and bone atrophy induced by unloading as well as chronic stress.
In the present investigation, we studied urinary excretion of stress related hormones during 7-day tail-suspension in three different age groups of female rats. In addition, we studied how estrogen influence muscle and bone atrophy utilizing ovariectomized and tail-suspended rats. I) The results showed that basal excretions of corticosterone (B), adrenaline (A) and noradrenaline (NA) in old rats were higher than those in young rats. The responsiveness of these hormones to stress induced by tail-suspension was different among B, A and NA.Urinary excretion of A was increased by the tail-suspension in both young rats and old rats, while increment of urinary excretion of B was lower in old rats. NA excretion did not show difference in both young and old rats. II) Wet weights of soleus and gastrocnemius muscle and of femur, and Ca and Pi contents of the femur were decreased in ovariecomized rats (Ovx). Decrease in wet weights of soleus and gastrocnemius muscle during tail-suspension was not prevented by estrogen administration (E2) to Ovx, but the bone atrophy was prevented Accordingly, urinary deoxypyridinoline excretion was significantly increased by suspension in Ovx, in contrast with no change in E2. A significant decrease of blood PTH (parathyroid hormone) was observed in Ovx, while it was not altered in E2. Therefore, it is concluded that E2 plays an important role in the maintenance of bone loss but not that of muscle.

  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 大森幸子他: "尾部懸垂ラットにおけるデオキシピリジノリンの尿中排泄の変動 -ビスフォス フォネートYH529の効果-" 名古屋大学環境医学研究所年報. 47. 3-6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野節子他: "廃用性骨萎縮に及ぼす加齢の影響-ラット尾部懸垂モデルを用いた検討" 名古屋大学環境医学研究所年報. 47. 7-10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野節子他: "加齢とストレス反応" 名古屋大学環境医学研究所年報. 47. 258-259 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大森幸子他: "尾部懸垂ラットにおける活性型ビタミンD3の変動-ビスフォスフォネートYH529の効果" 名古屋大学環境医学研究所年報. 48. 1-4 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野節子他: "ストレス関連ホルモンに及ぼす卵巣摘除の影響(尾部懸垂ラットにおける検討)" 名古屋大学環境医学研究所年報. 48. 5-8 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinji SAKANO et al.: "Protooncogene Expression in Osteogenesis Induced by Bone Morphogenetic protein." Clinical Orthopaedics and Related Research. 338. 240-246 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sachiko OHMORIet al.: "Effect of Bisphosphonate Administration on the Excretion of Stress Hormones in Tail-suspended Rats." Environmental Medicine. 41(1). 9-12 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazutoshi KUROKOUCHI et al.: "Activation of NF-κB by TNF-α in Rat Osteosarcoma ROS17/2.8 cells." Environmental Medicine. 41(1). 13-15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazutoshi KUROKOUCHI et al.: "Administration of Bisphosphonate Prevents Disuse Bone Atrophy Induced by Tail suspension." Environmental Medicine. 41(1). 16-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Setsuko KAWANO et al.: "Effect of Estrogen on the Development of Disuse Atrophy of Bone and Muscle Induced by Tail-Suspension in Rats." Environmental Medicine. 41(2). 89-92 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisao SEO et al.: "Changes in urinary excretion of pyridinium cross-links during Spacelab-J." Biological Sciences in Space. 11(4). 321-326 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sachiko OHMORI, et al.: "Changes in Urinary Excretion of Deoxypyridinoline in Tail-suspended Rats:Effect of a Bisphosphonate, YH529" Environmental Medicine. 42(1). 11-13 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Roy E. WEISS, et al.: "Thyroid hormone Action on Liver, Heart, and Energy Expenditure in Thyroid Hormone Receptor 3-Deficient Mice." Endocrinology. 139(12). 4945-4952 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi NAGAYA, et al.: "Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor α bycathepsin L-type protease is a potential mechanism for modulating thyroid hormone action." The Journal of Biological Chemistry. 273(50). 33166-33173 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野節子他: "加齢がストレス反応に及ぼす影響-尾部懸垂雌ラットにおけるストレス関連ホルモンの変動-" 名古屋女子大学紀要 自然家政編. 45. 111-118 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohmori, S.et al.: "Changes in urinary excretion of deoxy-pyridinoline in tail suspended rats : Effect of Bisphosphonate, YH529." Ann.Res, Inst.Environ., Nagoya Univ.47. 3-6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano, S.et al.: "Influence of aging on bone atrophy : The discussion of tail suspension in rats." Ann.Res, Inst.Environ., Nagoya Univ.47. 7-10 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano, S.et al.: "Aging and stress reaction." Ann.Res, Inst.Environ., Nagoya Univ.48. 258-259 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohmori, S.et al.: "Changes in serum 1,25 (OH)_2D_3.in tail suspended rats : Effect of Bisphosphonate, YH529." Ann.Res, Inst.Environ., Nagoya Univ.48. 1-4 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano, S.et al.: "Effect of ovariectomy on urinary excretion of stress-related hormones in a tail suspended rat : The discussion of tail suspension in rats." Ann.Res, Inst.Environ., Nagoya Univ.47. 5-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakano, S.et al.: "Protooncogene Expression in Osteo-genesis Induced by Bone Morpho-genetic protein." Clinical Orthopaedics and Related Research.338. 240-246 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohmori, S.et al.: "Effect of Bisphosphonate Administra-tion on the Excretion of Stress Hormones in Tail-suspended Rats." Environ.Med.41. 9-12 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KUROKOUCHI,K.et al.: "Activation of NF-kappaB by TNF-alpha in Rat Osteosarcoma ROS17/2.8 cells" Environ.Med.41. 13-15 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KUROKOUCHI,K.et al.: "Administration of Bisphosphonate Prevents Disuse Bone Atrophy Induced by Tail suspension." Environ.Med.41. 16-17 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano, S., et al.: "Effect of Estrogen on the Development of Disuse Atrophy of Bone and Muscle Induced by Tail-Suspension in Rats." Environ.Med.41. 89-92 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seo, H., et al.: "Changes in urinary excretion of pyridinium cross-links during Spacelab-J" Biological Sciences in Space. 11. 321-326 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohmori, S.et al.: "Changes in Urinary Excretion of Deoxypyridinoline in Tail-suspended Rats : Effect of a Bisphosphonate, YH5294" Environ.Med.42. 11-13 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] WEISS,R.E.et al.: "Thyroid hormone Action on Liver, Heart, and Energy Expenditure in Thyroid Hormone Receptor beta-Deficient Mice." Endocrinology. 139 (12). 4945-4952

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] NAGAYA,T.et al.: "Intracellular Proteolytic Cleavage of 9-cis-Retinoic Acid Receptor alpha by Cathepsin L-type Protease Is a Potential Mechanism for Modulating Thyroid Hormone Action" JBC.273 (50). 33166-33173 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano, S.et al.: "Influence of Aging on Stress Reaction-Changes in Stress Related Hormone Secretion during Tail Suspension in Female Rats-" J.Nagoya Women's Univ.45. 111-118 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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