1997 Fiscal Year Final Research Report Summary
Syntheses of Natural Radical Scavengers and Studies on their Functions
| Project/Area Number |
08680640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Kinki University |
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Principal Investigator |
KAMIKAWA Tadao Kinki University Department of Chemistry Professor, 理工学部, 教授 (40047006)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Synthesis / Radical Scavenger / Stealthin A / Stealthin C / 合成 |
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| Research Abstract |
Free radicals such as ROO can react at random by hydrogen abstraction and a variety of reactions to damage proteins, lipids and vitamins. Many diseases, such as atherosclerosis, inflammation and Perkinson's disease have been proven to be caused by oxygen-derived free radicals.
In this study, we succeeded the efficient synthesis of O^4, O^9-dimethylstealthin A and C,methylated derivatives of potent radical scavengers produced by Streptomyces viridochromogenes, using Suzuki coupling reaction as a key step. This work offers new, rather stable and useful compounds for studying free radical scavenging actions.
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