1997 Fiscal Year Final Research Report Summary
Biochemical Properties of Peptides Induced by Abnormal Occulusion
| Project/Area Number |
08835024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
咀嚼
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
ABE Kimio Fukuoka Dental College, Prof.Dos, Ph.D.Dept.Oral Biochem., 歯学部, 教授 (70076016)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Kazunari Accistant.Ph.D.Fukuoka Dental College, Dept.of Oral Biochemistry, 歯学部, 助手 (50122768)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Abnormal occulusion / Peptide / Saliva / Rat and human's / HPLC / Amino acid sequence / Primary structure / Glix-rich protein |
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| Research Abstract |
This study was designed to determine whether some proteins were affected by the abnormal occulusion and thereafter induced various peptides. Different dental treatment such as feeding with dental caries diet (D-2OOO), tooth extraction and orthodontic treatment was carried out in this study. In humans and rats, some proteins of parotid and submandibular salivas were affected by thee abnormal occulusion, but proline- and histidine-rich, and glutamine/glutamic acid-rich proteins were only degraded into various peptides. We do not know why such discrimination was occurred by the abnormal occulusion. Amino acid sequences and concentrations of induced peptides (P19, 20, 21, 24, 28 and 31, which we termed by HPLC) were elucidated and determined quantitatively after various treatments.
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[Publications] Abe, K., Okina, A., Yano, T., Gao, C., Ohmori, H., Ishibashi, K., Nishiura, T.andLetic-Gavrilovic, A.: "Abnormally high levels of cystatin S in submandibular glands, saliva and gingiva of plaqueresistant rats." J.Dent.Res.77(11). 1913-1919 (1998)
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[Publications] Yamada, K., Letic-Gavrilovic, A., Mori, M., Nishiura, T., Nagata, H.and Abe, K.: "Immunohistochemical and quantitative analysis of cystatin S in the submandibular and sublingual glands of rats" Stom.Glas.S.45. 19-25 (1998)
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[Publications] Tashiro.M., Letic-Gavrilovic, A., Nakamura, H., Ohkuma, K., Egashira, Y., Ohmori, H., Nagata, H., Harada, M.and Abe, K.: "The effects of 6-hydroxydopamine and potential antagonists on flow rates and protein secretion by rat submandibular glands." Stom.Glas.S.44. 131-137 (1997)
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[Publications] Moroi, R., Yamaza, T., Nishiura, T., Nishimura, Y., Terada, Y., Abe, K., Himeno, M.and Tanaka, T.: "Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo." Archs Oral Biol.42(4). 305-315 (1997)
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