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1998 Fiscal Year Final Research Report Summary

Novel Fluorinated Bioorganic Molecules for the 21st Century

Research Project

Project/Area Number 09044277
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field 医薬分子機能学
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

TAKEUCHI Yoshio  TOYAMA MED.PHARM.UNIV., PROFESSOR, 薬学部, 教授 (20111750)

Co-Investigator(Kenkyū-buntansha) KIRIHARA Masayuki  TOYAMA MED.PHARM.UNIV., ASSIST.PROFESSOR, 薬学部, 助手 (40262539)
TAKAHASHI Tamiko  TOYAMA MED.PHARM.UNIV., ASSIST.PROFESSOR, 薬学部, 助手 (10115181)
SHIBATA Norio  TOYAMA MED.PHARM.UNIV., LECTURER, 薬学部, 講師 (40293302)
KOMETANI Tadashi  TOYAMA NATIONAL COLLEGE OF TECH., PROFESSOR, 物質工学科, 教授 (60042842)
SATOH Toshio  TOKUSHIMA-BUNRI.UNIV., PROFESSOR, 薬学部, 教授 (70075943)
Project Period (FY) 1997 – 1998
KeywordsFluoro-amino Acid / Fluorine-containing Peptide / Isostere / Fluorination / Chiral Derivating Agent / Lipase / DAST
Research Abstract

This international joint project between Japan-USA-Germany entitled "Novel Fluorinated Bioorganic Molecules for the 21st Century" was started in 1997 with Prof.Yoshio Takeuchi of Toyama Medical and Pharmaceutical University as the head investigator, Dr.Kenneth L.Kirk of NIH, USA, Prof. Guenter Haufe of Westfalische-Wilhelms University, Germany, Prof. Toshio Satoh of Tokushima Bunri University, Prof. Tadashi Kometani of Toyama National College of Technology, Drs.Norio Shibata and Tamiko Takahashi of Toyama Medical and Pharmaceutical University as co-investigators. Two additional co-investigators, Prof.Siegfried Lodwig of Los Alamos Laboratory (Centralia College), USA, and Dr.Masayuki Kirihara of Toyama Medical and Pharmaceutical University were invited to this project when the amount of the grant was generously increased at the end of 1997. The numbers of international and domestic trips for collaborative work funded by the project for the period (1997/1998) are summarized as follows. Travels from Japan to USA (4) ; from Japan to Germany (4) ; from USA to Germany (2) ; from USA to Japan (3) ; from Germany to Japan (1), and domestic travels in Japan (6). As part of these travels by the participants of the project, each visiting collaborator has presented his/her up-to date research results. In addition, scientific exchanges made possible by these trips have provided information dealing with on-going research, and allowed discussions of time requirements, themes, and the style of future collaborations. As a result of such interchanges, a total of 60 scientific papers were published by these investigators for 1997/1998, and a total of more than 100 presentation were made at international and domestic scientific meetings.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Y.Takeuchi et al.: "Efficient Synthesis of A New, Highly Versatile Chiral Derivatizing Agent, α-Cyano-α-fluoro/p-tilylacetic Acid (CFTA)" Chem.Commun.1998. 365-366 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Takeuchi et al.: "Chemistry of α-Fluoro-α-amino Acids : The First Synthesis of α-Fluoro-glycine-containing Dipeptides" Chem.Pharm.Bull.46. 1062-1064 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.Haufe et al: "Synthesis of γ-Fluoro-α-methyl-α-amino Acids. A New Alkylation Procedure for Ester Imine" Tetrohedron. 54. 5929-5938 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Percy et al: "Synthesis of E-and Z-α-Fluorourocanoic Acids as Potential Inhibitors of Urocanes" J.Fluovine chem.91. 5-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yokoyama et al: "Asymmetric synthesis of chiral 2-Fluorinated 1,3-Propanediols and Its Application to the Preparation of Monofbcorinated chiral synthon" Tetrahedron Lett.39. 7741-7744 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kirihara et al: "Novel Fluorination of Small-ring Tertiary Cydoalkanels : Reaction of Diethylaminosulfur Trifluoride with Tertiary Cyclobutanols" J.Chem.Res.(S). 1998. 652-653 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Takeuchi et al.: "Chemistry of alpha-Fluoro-alpha-amino Acids : The First Synthesis of alpha-Fluoro-glycine-containing Dipeptides" Chem.Pharm.Bull.46. 1062-1064 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G.Haufe et al.: "Synthesis of alpha-Fluoro-alpha-methyl-alpha-amino Acids.A New Alkylation Procedure for Ester Imines" Tetrahedron. 54. 5929-5938 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Takeuchi et al.: "Synthesis of a New, Highly Versatile Chiral Derivatizing Agent, alpha-Cyano-alpha-fluoro-P-Totylacetic Acid (CFTA) ." Chem.Commun.365-366. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Percy et al.: "Synthesis of E- and Z-alpha-Fluorourocanic Acids as Potential Inhibitor of Urocanes" J.Fluorine Chem.91. 5-7 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yokoyama et al.: "Asymmetric Synthesis of Chiral 2-Fluorinated 1,3-Propanediols and its Application to the Preparation of Monofluorinated Chiral Synthon" Tetrehedron Lett.39. 7741-7744 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Kirihara et al.: "Novel Fluorination of Small-ring Tertiary Cycloalkanols : Reaction of Diethylaminosulfur Trifluride with Tertiary Cyclobutanols" J.Chem.Res. (s). 652-653. (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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