1998 Fiscal Year Final Research Report Summary
Genetic and molecular pathological studies on pathogens is of sudden infant death syndrome
| Project/Area Number |
09044356
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Field |
Pediatrics
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
TAKASHI Sachio National Institute of Neuroscience , National Center of Neurology and Psychiatry , Dep. , of Mental Retardation and Birth Defect Research , Director, 神経研究所, 部長 (70038743)
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| Co-Investigator(Kenkyū-buntansha) |
PAMPHLETT R. Sidney University, Dep., of Pathology, Professor, 教授
アームストロング D. テキサス小児病院病理学, 教授
BECKER L.,E. Hospital for Sick Children, University of Toronto, Dep., of Pathology, Professor, 小児科病院病理学, 教授
ONODERA Kazukiyo National Institute of Neuroscience, National Center of Neurology and Psychiatry, Guest Researcher, 研究員
YAMANOUCHI H National Institute of Neuroscience, National Center of Neurology and Psychiatry, Researcher
ARMSTRONG D. Texas Children Hospital, Dep., of Pathology, Professor
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| Project Period (FY) |
1997 – 1998
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| Keywords | sudden infant death syndrome / brainstem / respiratory regulation / neurotransmitter / chatecholamine / serotonin receptor |
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| Research Abstract |
Sudden infant death syndrome ( SIDS ) occurs during sleep and the most frequently at the age of 2 to 4 months . Its cause is not yet clarified , but the mechanism of SIDS is closely related to abnormal or immature neural regulation of cardiorespiratory system during sleep . The registration of SIDS starded in Japan , and the brains have been sent from all of the country . Our previous studies discloed a reactive astrogliosis , an increase of substance P , delayed development of synapse formation , a decrease of chatechoraminergic neurons in the brainstem . This decrease of chatechoraminergic neurons was found in the basal ganglia as well as the brainstem , and might be a predisposing factor for SIDS . In addition , serotonergic neurons were decreased in the respiratory centers of the brainstem , but serotonergic receptors were aqueductal gray of the midbrain which is an upper respiratory control center . The decreased serotonergic neurons and increased serotonergic receptors in periaqueductal gray were thought to be characteristic , and their network might be important in the pathogenesis of SIDS .
On the other hand , the collaboratory studies with Toronto and Sydney Universities progressed by visiting Prof. Becker in Toronto and Prof. Pamphlet in Sydney , and inviting Prof. Pamphlet to Japan who found an important connection of vertibular artery narrowing on prone position to brainstem gliosis .
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