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2001 Fiscal Year Final Research Report Summary

Comparative molecular biology of the natriuretic peptide system (Molecular dissection and mechanism of differentiation of chloride cells)

Research Project

Project/Area Number 09102008
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Institute of Technology

Principal Investigator

HIROSE Shigehisa  Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Professor, 大学院・生命理工学研究科, 教授 (10134199)

Co-Investigator(Kenkyū-buntansha) HAGIWARA Hiromi  Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Assistant Professor, 大学院・生命理工学研究科, 助教授 (90189465)
TAKEI Yoshio  University of Tokyo, Ocean Research Institute, Professor, 海洋研究所, 教授 (10129249)
Project Period (FY) 1997 – 2001
KeywordsOsmoregulation / Natriuretic peptide / Chloride cell / Eel / Dace / Acid adaptation / K channel / ウグイ
Research Abstract

We used the comparative approach to gain insights into the complex regulatory system of the body fluid homeostasis by using animals with morphological and functional specializations such as the eel that can survive both in freshwater and seawater and the Osorezan dace that can live and grow in a pH 3.5 lake. (1) Through the analyses of both ligands and the corresponding receptors, we showed that the natriuretic peptide (NP) system is a key endocrine system that governs the euryhalinity of eel. NP is not only involved in quick regulation of various pre-existing transporters upon transfer to different salinities, but also stimulates secretion of cortisol and growth hormone, thereby being involved in long-term adaptation. We also identified NPs from diverse vertebrate species that perform unique osmoregulation such as sharks and hagfish to assess molecular evolution of the NP family. (2) Molecular mechanism of acid adaptation of the Osorezan dace was clarified by identifying ion transporters, channel, and their related molecules that become highly induced when dace are transferred from neutral to acidic water. Furthermore, the molecules responsible for the acid tolerance were mainly expressed in chloride cells. (3) Osmoregulation in teleost fish is achieved largely through active salt transport by specialized cells known as chloride cells. Reflecting their extraordinary power of ion transport, chloride cells are rich in Na, K-ATPase. Exploiting this unique property of the chloride cell, we succeeded in identifying a K channel likely to be functionally coupled with Na, K-ATPase ; identification of such a K channel has been a long-standing goal in animal physiology. (4) Autoradiographic localization of eel NP receptor revealed an unexpectedly dense localization in the gill chondrocytes, suggesting tight relationship between the NP system and bone metabolism, which then open a new avenue in the field of bone research.

  • Research Products

    (196 results)

All Other

All Publications (196 results)

  • [Publications] Hiruma, Y.et al.: "Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat cadvariae"Biochem.Biophys.Res.Commun.. 230. 176-178 (1997)

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  • [Publications] Itakura, M.et al.: "Structural analysis of natriuretic peptide receptor-C (NPR-C) by truncation and site-directed mutagenesis"Biochem.J.. 322. 585-590 (1997)

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  • [Publications] Nagase, M.et al.: "Role of natriuretic peptide receptor type C in Dahl salt-sensitive rats"Hypertension. 30. 177-183 (1997)

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  • [Publications] Nagase, M.et al.: "Tissue distribution and localization of natriuretic peptide receptor subtypes in stroke-prone spontaneously hypertensive rats"J.Hypertens.. 15. 1235-1243 (1997)

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  • [Publications] Nagase, M.et al.: "Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats"Biochem.Biophys.Res.Commun.. 237. 496-498 (1997)

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  • [Publications] Tagawa, M.et al.: "Partial cloning of the hormone-binding domain of the cortisol receptor in tilapia,Oreochromis mossambicus,and changes in the mRNA level during embryonic development"Gen.Comp.Endocrinol.. 108. 132-140 (1997)

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  • [Publications] Tierney, M.L.et al.: "The presence of angiotensin receptors in elasmobranchs"Gen.Comp.Endocrinol.. 105. 9-17 (1997)

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  • [Publications] Olson, K.R.et al.: "Effects of natriuretic peptides and nitroprusside on venous function in trout"Am.J.Physiol.. 273. R527-R539 (1997)

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  • [Publications] Kato, A.et al.: "Targeting of endopeptidase 24.16 to different subcellular compartments by alternative promoter usage"J.Biol.Chem.. 272. 15313-15322 (1997)

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  • [Publications] Matsuda, K.et al.: "Isolation and structural characterization of pituitary adenylate cyclase activating polypeptide(PACAP)-like peptide from the brain of a teleost,stargazer,Uranoscops japonicus"Peptides. 18. 723-727 (1997)

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  • [Publications] Mishina, S., Takei, Y.: "Characterization of natriuretic peptide receptors in eel gill"J.Endocrinol.. 154. 415-422 (1997)

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  • [Publications] Yoshida, A.et al.: "Primary structure of bullfrog calcitonin"Gen.Comp.Endocrinol.. 107. 147-152 (1997)

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  • [Publications] Kaiya, H., Takei, Y.: "nteraction of osmotic and volemic mechanisms in secretion of atrial and ventricular natriuretic peptide in eels"Gen.Comp.Endocrinol.. 107. 322-326 (1997)

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  • [Publications] Takei, Y.et al.: "A new natriuretic peptide isolated from cardiac atria of rainbow trout"FEBS Lett.. 414. 377-380 (1997)

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  • [Publications] Loretz, C.A.et al.: "Local synthesis of natriuretic peptides in the eel intestine"Biochem.Biophys.Res.Commun.. 238. 817-822 (1997)

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  • [Publications] Takei, Y.et al.: "Cloning,sequence analysis,tissue-specific expression,and prohormone isolation of eel atrial natriuretic peptide"Zool.Sci.. 14. 985-1001 (1997)

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  • [Publications] 竹井祥郎: "海に生きる"月刊海洋. 号外No.12. 1-5 (1997)

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  • [Publications] 海谷啓之, 竹井祥郎: "浸透圧調節と心臓のホルモン"比較生理生化学. 14. 13-27 (1997)

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  • [Publications] Uchiyama, M., et al.: "Effects of homologous atrial,brain,and C-type natriuretic peptides on isolated heart and blood vessels of bullfrog"Zool.Sci.. 14. 843-848 (1997)

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  • [Publications] Matsuda, K.et al.: "Pituitary adenylate cyclase-activating polypeptide(PACAP)in fishes: purification,distribution and physiological function"Advances in Comparative Endocrinology (eds.S.Kawashima and S.Kikuyama),Monduzzi Editore,Bologna. 687-691 (1997)

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  • [Publications] Loretz, C.A., Takei, Y.: "Stimulated local release of natriuretic peptides by intestine of the Japanese eel"Advances in Comparative Endocrinology (eds.S.Kawashima and S.Kikuyama),Monduzzi Editore,Bologna. 1221-1224 (1997)

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  • [Publications] Hazon, N.et al.: "Elasmobranch renin-angiotensin system and the angiotensin receptor"Advances in Comparative Endocrinology (eds.S.Kawashima and S.Kikuyama),Monduzzi Editore,Bologna. 1307-1312 (1997)

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  • [Publications] Tierney, M.L.et al.: "Interactions between the renin-angiotensin system and catecholamines on the cardiovascular system of elasmobranchs"Fish Physiol.Biochem. 17. 333-337 (1997)

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  • [Publications] Loretz, C.A., Takei, Y.: "Natriuretic peptide inhibition of intestinal salt absorption in the Japanese eel: physiological significance"Fish Physiol.Biochem.. 17. 319-324 (1997)

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  • [Publications] Kobayashi, H., Takei, Y.: "The-Renin-Angiotensin System: Comparative Aspects"Zoophysiology. 35. 1-245 (1997)

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  • [Publications] 柴崎 学, 他: "Na利尿ペプチド受容体と浸透圧適応"海洋. 30. 85-89 (1998)

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  • [Publications] 広瀬茂久: "Na利尿ペプチド受容体"生体の科学. 48. 513-516 (1998)

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  • [Publications] 萩原啓実, 他: "血管作動性ペプチドによる骨代謝の調節"最新医学. 53. 1289-1294 (1998)

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  • [Publications] Hagiwara, H.et al.: "Deceleration by angiotensin II of the differentiation and bone formation of rat calvarial osteoblastic cells"J.Biol.Chem.. 156. 543-550 (1998)

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  • [Publications] Hiruma, Y.et al.: "Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor"Am.J.Physiol.. 275. R1099-R1105 (1998)

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  • [Publications] Hiruma, Y.et al.: "Endothelins inhibit mineralization of rat calvarial osteoblast-like cells"J.Cardiovasc.Pharmacol.. 31. S521-S523 (1998)

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  • [Publications] Otsuka E., et al.: "Effects of nitric oxide from oxogenous nitric oxide donors on osteoblastic metabolism"Eur.J.Pharmacol.. 349. 345-350 (1999)

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  • [Publications] Nagase, M.et al.: "Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor(LOX-1)gene"J.Biol.Chem.. 273. 33702-33707 (1998)

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  • [Publications] Nagase, M.et al.: "Unique repetitive sequences and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein(LOX-1)"Biochem.J.. 330. 1417-1422 (1998)

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  • [Publications] Suzuki, Y.et al.: "Cloning and properties of a hypertonicity-inducible inward rectifier K^+ channel from euryhaline eels"Cell Volume Regulation(Y.Okada ed.),Amsterdam,Elsevier. 159-166 (1998)

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  • [Publications] Takei, Y.et al.: "Tetrapod-type[Aps_1]angiotensin is present in a primitive holostean fish,Amia calva"Gen.Comp.Endocrinol.. 110. 140-146 (1998)

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  • [Publications] Sakaguchi, H., Takei, Y.: "Characterisation of C-type natriuretic peptide receptors in the gill of dogfish Triakis scyllia"J.Endocrinol.. 156. 127-134 (1998)

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  • [Publications] Tierney, M.L.et al.: "A radioimmunoassay for the detection of angiotensin II in elasmobranch fish"Gen.Comp.Endocrinol.. 111. 299-305 (1998)

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  • [Publications] Takei, Y.et al.: "Antidiuretic effect of eel ANP infused at physiological doses in seawater-adapted eels,Anguill japonica"Zool.Sci.. 15. 399-404 (1998)

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  • [Publications] Takei, Y.et al.: "Evaluation of water intake in seawater adaptation in eels using a synchronized drop counter and pulse injector system"Zool.Sci.. 15. 677-682 (1998)

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  • [Publications] Tsuchida, T., et al.: "Effect of homologous atrial natriuretic peptide on drinking and plasma angiotensin II level in eels"Am.J.Physiol.. 230. R1605-R1610 (1998)

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  • [Publications] Suzuki N.et al.: "Amino acid sequenxes of N-terminal procalcitonin of some vertebrates"Nether.J.Sool.. 48. 349-360 (1998)

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  • [Publications] Hamano, K.et al.: "Direct vasoconstrictor action of homologous angiotensin II on isolated aterial ring preparation in an elasmobranch fish"J.Endocrinol.. 158. 419-423 (1998)

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  • [Publications] Abe, J.et al.: "Ig-Hepta,a novel member of the G protein-coupled hepta-helical receptor(GPCR)family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs"J.Biol.Chem.. 247. 19957-19964 (1999)

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  • [Publications] Hagiwara, H.et al.: "Ipriflavone down-regulates endothelin receptor levels during differentiation of rat calvarial osteoblast-like cells"J.Biochem.. 126. 168-173 (1999)

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  • [Publications] Honda, S.et al.: "Regulation by 1a,25-dihydroxyvitamin D3 of expression of stanniocalcin message in the rat kidney and ovary"FEBS Lett.. 459. 119-122 (1999)

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  • [Publications] Inoue, A.et al.: "Correlation between induction of expression of biglycan and mineralization by C-type natriuretic peptide in osteoblastic cells"J.Biochem.. 125. 103-108 (1999)

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  • [Publications] Kashiwagi, M.et al.: "Cloning,properties and tissue distribution of natriuretic peptide receptor-A of euryhaline eel,Anguilla japonica"Eur.J.Biochem.. 259. 204-211 (1999)

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  • [Publications] Nagase, M.et al.: "Retrotransposons transcribed preferentially in proximal tubules of salt-hypertensive rat"Kidney International. 55. 995-1004 (1999)

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  • [Publications] Nakamura, N.et al.: "Inwardly rectifying potassium channel Kir7.1 is highly expressed in the thyroid follicular cells,intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na^+,K^+-ATPase"Biochem.J.. 342. 329-336 (1999)

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  • [Publications] Massarelli, E.E.et al.: "Differential subcellular distribution of neurolysin(EC 3.4.24.16)and thimet oligopeptidase(EC 3.4.24.15)in the rat brain"Brain Res.. 851. 261-265 (1999)

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  • [Publications] Otsuka, E.et al.: "Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid"Am.J.Physiol.. 277. C132-C138 (1999)

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  • [Publications] Suzuki Y.et al.: "Identification by differential display of a hypertonicity-inducible inward rectifier pottasium channel highly expressed in chloride cells"J.Biol.Chem.. 274. 11376-11382 (1999)

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  • [Publications] Schalkwijk, J.et al.: "The trappin gene family:proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulfide core"Biochem.J.. 259. 569-577 (1999)

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  • [Publications] Takei, Y.et al.: "Interaction of the natriuretic peptide system and renin-angiotensin system in eel osmoregulation"Recent Developments in Comparative Endocrinology and Neurobiology(E.W.Roubos,et al.,eds.,Shaker Publishers,Maastricht,The Netherlands). 144-188 (1999)

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  • [Publications] Miyazaki, H.et al.: "Molecular cloning of CLC channels in Oreocromis mossambicus and their functional complementation of yeast CLC gene mutant"Biochem.Biophys.Res.Commun.. 225. 175-181 (1999)

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  • [Publications] McKendry, J.E.et al.: "Natriuretic peptides and the control of catecholamine release in two freshwater teleost and a marine elasmobranch fish"Fish Physiol.Biochem.. 20. 61-77 (1999)

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  • [Publications] Hazon N.et al.: "The renin-angiotensin system in elasmobranch fish:A review"J.Exp.Zool.. 284. 526-534 (1999)

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  • [Publications] Bernier, N.J.et al.: "Cardiovascular control via angiotensin II and circulating catecholamines in the spiny dogfish,Squalus acanthias"J.Comp.Physiol.. B169. 237-248 (1999)

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  • [Publications] Bernier, N.J.et al.: "Mediation of humoral catecholamine sedretion by the renin-angiotensin system in nypotensive raibou trout(Onchrohynchus mykiss)"J.Endocrinol.. 160. 351-363 (1999)

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  • [Publications] Joss, J.M.P.et al.: "Teleost-type angiotensin is present in Australian lungfish,Neoceratodus forsteri"Gen.Comp.Endocrinol.. 114. 206-212 (1999)

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  • [Publications] Tsuchida, T., Takei, Y.: "Interaction of ANP and ANGII in regulation of drinking in eels"Recent Progress in Molecular and Comparative Endocrinology(H.B.Kwon et al.eds)Hormone Research Center,Chonnam National University,Kwangyu. 453-459 (1999)

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  • [Publications] Tsuchida, T., Takei, Y.: "A potent dipsogenic action of homologous angiotensin II infused at physiological doses in eels,Anguilla japonica"Zool.Sci.. 16. 479-483 (1999)

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  • [Publications] Suzuki, Y.et al.: "Localization of porcine trappin-2(SKALP/elafin)in trachea and large intestine by in situ hybridization and immunohistochemistry"Histochem.Cell Biol.. 114. 15-20 (2000)

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  • [Publications] Hirata, T, et al.: "Maintenance of acid-base balance by Na+/H+ exchanger(MHE3)and Na+/HCO3-cotransporter(NBC)in the gill of dace adapted to extremely acidic conditions(pH3.5)"Control and eiseases of sodium Department Transport Proteins and Ion Channels(Syjetam Y.,et al.eds)Elsivier,Amsterdam. 127-128 (2000)

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  • [Publications] Honda, S.et.al.: "Multiplicity,structures,and endocrine and exocrine natures of eel fucose-binding lectins"J.Biol.Chem.. 275. 33151-33157 (2000)

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  • [Publications] Inoue, A..et al.: "The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis"Biochem.Biophys.Res.Commun.. 273. 398-403 (2000)

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  • [Publications] IInoue, A..et al.: "Vasoactive peptide-regulated gene expression during osteoblastic differentiation[In Process Citation]"J.Cardiovasc.Pharmacol.. 36. S286-S289 (2000)

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  • [Publications] Koyama, A.et al.: "Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E(2)"Eur.J.Pharmacol.. 391. 225-231 (2000)

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  • [Publications] Nakamura, N.et al.: "Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1"J.Biol.Chem. 275. 28276-28284 (2000)

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  • [Publications] Nagase, T.et.al.: "Crouzon syndrome with acanthosis nigricans: case report and mutational analysis"Cleft Palate Craniofac.J.. 37. 78-82 (2000)

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  • [Publications] Ookata, K.et al.: "Localization of inward rectifier potassium channel Kir7.1 in the basal membrane of distal nephron"J.Am.Soc.Nephrol.. 11. 1987-1994 (2000)

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  • [Publications] Otsuka, E.et al.: "IRole of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix.Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix"Endocrinology. 141. 3006-3011 (2000)

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  • [Publications] Yada, T.et al.: "Effects of desacetyl-α-MSH on lipid mobilization in teh raibou trout, Oncohynchus mykiss"Zool.Sci.. 17. 1123-1127 (2000)

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  • [Publications] Yamashita, Y.et al.: "Concentration of mRNA for the natriuretic peptide receptor-C in hypertrophic chondrocytes of the fetal mouse tibia"J.Biochem.. 127. 177-179 (2000)

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  • [Publications] Furutani, Y.et al.: "A simple assay and histochemical localization of transglutaminase activity using a derivative of green fluorescent protein as substrate"J.Histochem.Cytochem.. 49. 247-258 (2000)

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  • [Publications] Takei Y.: "Structural and functional evolution of the natriuretic peptide system in vertebrates"Int.Rev.Cytol.. 194. 1-66 (2000)

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  • [Publications] Takei, Y.: "Comparative physiology of body fluid regulation in vertebrates with special reference to thirst regulation"Jpn.J.Physiol.. 50. 171-186 (2000)

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  • [Publications] Takei, Y.et.al.: "Role of the renin-angiotensin system in drinking of seawater-adapted eels,Anguilla japonica: A reevaluation"Am.J.Physiol.. 279. R1105-R1111 (2000)

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  • [Publications] Smith, M.et al.: "Similarity of vasorelaxant effects of natriuretic peptides in isolated blood vessels of salmonids"Physiol.Biochem.Zool.. 73. 494-500 (2000)

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  • [Publications] Tanaka, N.et al.: "Elafin is induced in epidermis in skin desorders with dermal neutrophilic infiltration:interleukin-1 beta and tumour necrosis factor-alpha stimulate its secretion in vitro"Br.J.Dermatol.. 143. 728-732 (2000)

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  • [Publications] Tanaka, N.et al.: "Levels of proelafin peptides in the sera of the patients with generalized pustular psoriasis and pustulosis palmoplantarisl"Acta Derm.venoreol.. 143. 102-105 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirose, S.et al.: "Comparative molecular biology of natriuretic peptide receptors"Can.J.Physiol.Pharmacol.. 79. 665-672 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mistry, A.C.et al.: "Eel urea transporteric located to chloride cells and is salinity dependent"Am.J.Physiol.. 281. R1594-R1604 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mistry, A.C.et al.: "Structure,properties and enhanced expression of glactose-binding C-type lectins in mucous cells of gills from freshwater eels"Biochemical Journal. 360. 107-115 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ookata, K.et al.: "Distribution of stanniocalcin 1 in the apical membranes of the distal nephron of rat kidney and its regulation by vitamin D3"Exp.Nephrol. 9. 428-435 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei, Y.et al.: "Enhanced expression and release of C-type natriuretic peptide in freshwater eels,Anguilla japonica"Am.J.Physiol.. 280. R1727-R1735 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei, Y.: "Comparative physiology of body fluid regulation in veterbrates"Comp.Biochem.Physiol.. B129. 171-186 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei, Y.et al.: "Does the natriuretic peptide system exist throughout the animal and plant kingdom?"Comp.Biochem.Physiol.. B129. 559-573 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anderson, W.G.et al.: "Possible interaction between the renin angiotensin system and natriuretic peptides on drinking in elasmobranchs"Perspectives in Comparative Endocrinology: Unity and Diversity,H.J.Th.Goos,et al.eds.,Monduzzi Editore,Bologna. 753-758 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anderson, W.G.et al.: "Angiotensin and angiotensin receptors in cartilaginous fishes"Comp.Biochem.Physiol.. A128. 31-40 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cerra, M.C.et al.: "Angiotensin II binding sites in the heart of Scyliorhinus cannicula: An autoradiographic study"Gen.Comp.Endocrinol. 121. 126-134 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei, Y.et al.: "Antidipsogenic effect of eel bradykinin in the eel,Anguilla japonica"Am.J.Physiol.. 281. R1090-R1096 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakoshi, A.et al.: "CNP is the only natriuretic peptide in a elasmobranch fish,Triakis scyllia"Zool.Sci.. 18. 861-868 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei, Y.et al.: "Ambient temperature regulates drinking rate and arterial pressure in eels"Zool.Sci. 18. 963-967 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekiguchi, T.et al.: "Molecular cloning of natriuretic peptide receptor A from bullfrog(Rana catesbeiana)brain and its functional expression"Gene. 273. 251-257 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsukada, et al.: "Relative potency of three homologous natriuretic peptide(ANP,CNP and VNP)in eel osmoregulation"Zool.Sci.. 18. 1253-1258 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anderson, W.G.et al.: "The dipsogenic effect of the renin-angiotensin system in elasmobranch fish"Gen.Comp.Endocrinol. 125. 300-307 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue, A.et al.: "Identification of a novel osteobalstic gene,Inducible by C-type natriuretic peptide,whose transcript might function in mineralization as a noncoding RNA"Calcif.Tissue Int.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹井祥郎, 広瀬茂久: "ホメオスタシス(日本内分泌学会編,ホルモンの分子生物学7)"学会出版センター. 200 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹井祥郎: "「ホルモンから見た生命」比較することの意味と面白さ"講談社ブルーバックス. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiruma, Y., et al.: "Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat cadvariae"Biochem. Biophys. Res. Commun.. 230. 176-178 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itakura, M. et al.: "Structural analysis of natriuretic peptide receptor-C (NPR-C) by truncation and site-directed mutagenesis."Biochem. J.. 322. 585-590 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato, A. et al.: "Targeting of endopeptidase 24. 16 to different subcellular compartments by alternative promoter usage."J. Biol. Chem.. 272. 115313-15322 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, M. et al.: "Role of natriuretic peptide receptor type C in Dahl salt-sensitive rats."Hypertension. 30. 177-193 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, M. et al.: "Tissue distribution and localization of natriuretic peptide receptor subtypes in stroke-prone spontaneously hypertensive rats."J. Hypertens.. 15. 1235-1243 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tagawa, M. et al.: "Partial cloning of the hormone-binding domain of the cortisol receptor in tilapia, Oreochromis mossambicus, and changes in the mRNA level during embryonic development."Gen. Comp. Endocrinol.. 108. 132-140 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, M. et al.: "Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats."Biochem. Biophys. Res. Commun.. 237. 496-498 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, H. & Takei, Y.: "The-Renin-Angiotensin System : Comparative Aspects."Zoophysiology. 35. 1-245 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tierney, M. L., et al.: "The presence of angiotensin receptors in elasmobranchs."Gen. Comp. Endocrinol.. 105. 9-17 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Olson, K. R., et al.: "Effects of natriuretic peptides and nitroprusside on venous function in trout."Am. J. Physiol.. 273. R527-R539 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda, K., et al.: "Isolation and structural characterization of pituitary adenylate cyclase activating polypeptide (PACAP)-like peptide from the brain of a teleost, stargazer, Uranoscops japonicus."Peptides. 18. 723-727 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mishina, S. and Takei, Y.: "Characterization of natriuretic peptide receptors in eel gill."J. Endocrinol.. 154. 415-422 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida, A., et al.: "Primary structure of bullfrog calcitonin."Gen. Comp. Endocrinol.. 107. 147-152 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaiya, H. and Takei, Y. et al.: "Interaction of osmotic and volemic mechanisms in secretion of atrial and ventricular natriuretic peptide in eels."Gen. Comp. Endocrinol.. 107. 322-326 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "A new natriuretic peptide isolated from cardiac atria of rainbow trout."FEBS Lett.. 414. 377-380 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Loretz, C. A., et al.: "Local synthesis of natriuretic peptides in the eel intestine."Biochem. Biophys. Res. Commun.. 238. 817-822 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "Cloning, sequence analysis, tissue-specific expression, and prohormone isolation of eel atrial natriuretic peptide"Zool. Sci.. 14. 985-1001 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchiyama, M., et al.: "Effects of homologous atrial, brain, and C-type natriuretic peptides on isolated heart and blood vessels of bullfrog."Zool. Sci.. 14. 843-848 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda, K. et al. et al.: "Pituitary adenylate cyclase-activating polypeptide (PACAP) in fishes : purification, distribution and physiological function."Advances in Comparative Endocrinology (eds. S. Kawashima and S. Kikuyama), Monduzzi Editore, Bologna.. 687-691 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Loretz, C. A. and Takei, Y. et al.: "Stimulated local release of natriuretic peptides by intestine of the Japanese eel."Advances in Comparative Endocrinology (eds. S. Kawashima and S. Kikuyama), Monduzzi Editore, Bologna.. 1221-1224 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hazon, N., et al.: "Elasmobranch renin-angiotensin system and the angiotensin receptor. In : Advances in Comparative Endocrinology"Advances in Comparative Endocrinology (eds. S. Kawashima and S. Kikuyama), Monduzzi Editore, Bologna.. 1307-1312 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tierney, M. L., et al.: "Interactions between the renin-angiotensin system and catecholamines on the cardiovascular system of elasmobranchs"Fish Physiol. Biochem.. 17. 333-337 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Loretz, C. A. and Takei, Y.: "Natriuretic peptide inhibition of intestinal salt absorption in the Japanese eel : physiological significance."Fish Physiol. Biochem.. 17. 319-324 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hagiwara, H. et al.: "Deceleration by angiotensin II of the differentiation and bone formation of rat calvarial osteoblastic cells."J. Endocrinol.. 156. 543-550 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiruma, Y. et al.: "Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor."Am. J. Physiol.. 275. R1099-R1105 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiruma, Y. et al.: "Endothelins inhibit mineralization of rat calvarial osteoblast-like cells."J. Cardiovasc. Pharmacol.. 31. S521-S523 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Otsuka, E., et al.: "Effects of nitric oxide from exogenous nitric oxide donors on osteoblastic metabolisem."Eur. J. Pharmacol.. 349. 345-350 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, M. et al.: "Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene."J. Biol. Chem.. 273. 33702-33707 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, M. et al.: "Unique repetitive sequences and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1)."Biochem. J.. 330. 1417-1422 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, Y. et al.: "Cloning and properties of a hypertonicity-inducible inward rectifier K^+ channel from euryhaline eels."Cell Volume Regulation (Y. Okada ed. ), Amsterdam, Elsevier.. 159-166 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "Tetrapod-type [Asp1] angiotensin is present in a primitive holostean fish, Amia calva."Gen. Comp. Endocrinol. 110. 140-146 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaguchi, H. and Takei, Y.: "Characterisation of C-type natriuretic peptide receptors in the gill of dogfish."J. Endocrinol.. 156. 127-134 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tierney, M. L., Takei, Y. and Hazon, N.: "A radioimmunoassay for the detection of angiotensin II in elasmobranch fish."Gen. Comp. Endocrinol.. 111. 299-305 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y. and Kaiya, H.: "Antidiuretic effect of eel ANP infused at physiological doses in seawater-adapted eels, Anguilla japonica."Zool. Sci.. 15. 399-404 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "Evaluation of water intake in seawater adaptation in eels using a synchronized drop counter and pulse injector system."Zool. Sci.. 15. 677-682 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, T. and Takei, Y.: "Effects of homologous atrial natriuretic peptide on drinking and plasma angiotensin II level in eels."Am. J. Physiol.. 275. R1605-R1610 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N., et al.: "Amino acid sequences of N-terminal procalcitonin of some vertebrates."Nether. J. Zool.. 48. 349-360 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamano, K., et al.: "Direct vasoconstrictor action of homologous angiotensin II on isolated arterial ring preparation in an elasmobranch fish."J. Endocrinol.. 158. 419-423 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Abe, J. et al.: "Ig-Hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs."J. Biol. Chem.. 247. 19957-19964 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hagiwara, H. et al.: "Ipriflavone down-regulates endothelin receptor levels during differentiation of rat calvarial osteoblast-like cells."J. Biochem.. 126. 168-173 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Honda, S. et al.: "Regulation by la, 25-dihydroxyvitamin D3 of expression of stanniocalcin message in the rat kidney and ovary."FEBS Lett.. 459. 119-122 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, A. et al.: "Correlation between induction of expression of biglycan and mineralization by C-type natriuretic peptide in osteoblastic cells."J. Biochem.. 125. 103-108 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kashiwagi, M. et al.: "Cloning, properties and tissue distribution of natriuretic peptide receptor-A of euryhaline eel, Anguilla japonica."Eur. J. Biochem.. 259. 204-211 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, M. et al.: "Retrotransposons transcribed preferentially in proximal tubules of salt-hypertensive rat."Kidney International. 55. 995-1004 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura, N. et al.: "Inwardly rectifying potassium channel Kir7. 1 is highly expressed in the thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells : implication for a functional coupling with Na^+, K^+-ATPase."Biochem. J.. 342. 329-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Massarelli, E. E. et al.: "Differential subcellular distribution of neurolysin (EC 3. 4. 24. 16) and thimet oligopeptidase (EC 3. 4. 24. 15) in the rat brain."Brain Res.. 851. 261-265 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Otsuka E., et al.: "Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid."Am. J. Physiol.. 277. C132-C138 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki Y. et al.: "Identification by differential display of a hypertonicity-inducible inward rectifier pottasium channel highly expressed in chloride cells."J. Biol. Chem.. 274. 11376-11382 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "Interaction of the natriuretic peptide system and the reanin-angiotensin system in eel osmoregulation."Recent Developments in Comparative Endocrinology and Neurobiology, Eds. E. W. Roubos, S. E. Wendelaar Bonga, H. Vaudry, and A. De Loof, Shaker Publishers, Maastricht, The Netherlands.. 144-148

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyazaki, H., et al.: "Molecular cloning of CLC chloride channels in Oreochromis mossambicus and their functional complementation of yeast CLC gene mutant."Biochem. Biophys. Res. Commun.. 255. 175-181 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] McKendry, J. E., et al.: "Natriuretic peptides and the control of catecholamine release in two freshwater teleost and a marine elasmobranch fish."Fish Physiol. Biochem.. 20. 61-77 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hazon, N., et al.: "The renin-angiotensin system in elasmobranch fish : A review."J. Exp. Zool.. 284. 526-534 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bernier, N. J., et al.: "Cardiovascular control via angiotensin II and circulating ca techolamines in the spiny dogfish, Squalus acanthias."J. Comp. Physiol. B. 169. 237-248 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bernier, N. J., et al.: "Mediation of humoral catecholamine secretion by the renin-angiotensin system in hypotensive rainbow trout (Onchrhynchus mykiss)."J. Endocrinol.. 160. 351-363 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Joss, J. M. P., et al.: "Teleost-type angiotensin is present in Australian lungfish, Neoceratodus forsteri."Gen. Comp. Endocrinol.. 114. 206-212 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, T., and Takei, Y.: "Interaction of ANP and ANGII in regulation of drinking in eels."Recent Progress in Molecular and Comparative Endocrinology, eds. H. B. Kwon, J. M. P. Joss, and S. Ishii, Hormone Research Center, Chonnam National University, Kwangju. 453-459 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, T., and Takei, Y.: "A potent dipsogenic action of homologous angiotensin II infused at physiological doses in eels, Anguilla japonica."Zool. Sci.. 16. 479-483 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, Y. et al.: "Localization of porcine trappin-2 (SKALP/elafin) in trachea and large intestine by in situ hybridization and immunohistochemistry."Histochem. Cell Biol.. 114. 15-30 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirata, T., et al.: "Maintenance of acid-base balance by Na+/H+ exchanger (NHE3) and Na+/HCO3- ofdNzpodfsd (NBC) in the gill of dace adapted to extremely acidic conditions (pH 3.5)."Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels. (Suketa, Y., et al. eds. ) Elsevier, Amsterdam. 127-128 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Honda, S. et. al.: "Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins."J. Biol. Chem.. 275. 33151-33157 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, A., et al.: "The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis."Biochem. Biophys. Res. Commun.. 273. 398-403 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] IInoue, A. . et al.: "Vasoactive peptide-regulated gene expression during osteoblastic differentiation [In Process Citation]."J. Cardiovasc. Pharmacol.. 36. S286-S289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase, T. et al.: "Crouzon syndrome with acanthosis nigricans : case report and mutational analysis."Cleft Palate Craniofac. J.. 37. 78-82 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koyama, A. et al.: "Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E(2)."Eur. J. Pharmacol.. 391. 225-231 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura, N. et al.: "Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1."J. Biol. Chem.. 275. 28276-28284 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ookata, K. et al.: "Localization of inward rectifier potassium channel Kir7. 1 in the basal membrane of distal nephron."J. Am. Soc. Nephrol.. 11. 1987-1994 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furutani, Y. et al.: "A simple assay and histochemical localization of transglutaminase activity using a derivative of green fluorescent protein as substrate."J. Histochem. Cytochem.. 49. 247-258 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Otsuka, E. et al.: "Role of ascorbic acid in the osteoclast formation : induction of osteoclast differentiation factor with formation of the extracellular collagen matrix."Endocrinology. 141. 3006-3011 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei Y.: "Structural and functional evolution of the natriuretic peptide system in vertebrates."Int. Rev. Cytol.. 194. 1-66 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y.: "Comparative physiology of body fluid regulation in vertebrates with special reference to thirst regulation."Jpn. J. Physiol.. 50. 171-186 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., and Tsuchida, T.: "Role of the renin-angiotensin system in drinking of seawater-adapted eels, Anguilla japonica : A reevaluation."Am. J. Physiol.. 279. R1105-R1111 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Smith, M. P., et al.: "Similarity of vasorelaxant effects of natriuretic peptides in isolated blood vessels of salmonids."Physiol. Biochem. Zool.. 73. 494-500 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirose, S. et al.: "Comparative molecular biology of natriuretic peptide receptors"Can. J. Physiol. Pharmacol.. 79. 665-672 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mistry, A. C. et al.: "Structure, properties and enhanced expression of glactose-binding C-type lectins in mucous cells of gills from freshwater eels"Biochem. J.. 360. 107-115 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mistry, A. C. et al.: "Eel urea transporteric located to chloride cells and is salinity dependent"Am. J. Physiol.. 281. R1594-R1604 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ookata, K. et al.: "Distribution of stanniocalcin 1 in the apical membranes of the distal nephron of rat kidney and its regulation by vitamin D3"Exp. Nephrol. 9. 428-435 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "Enhanced expression and release of C-type natriuretic peptide by the heart of freshwater eels, Anguilla japonica."Am. J. Physiol.. 280. R1727-R1735 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y.: "Does the natriuretic peptide system exist throughout the animal and plant kingdom?"Comp. Biochem. Physiol. B. 129. 559-573 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anderson, W. G., et al.: "Possible interaction between the renin angiotensin system and natriuretic peptides on drinking in elasmobranchs."CPerspectives in Comparative Endocrinology : Unity and Diversity, H. J. Th. Goos, R. K. Rastogi, H. Vaudry, R. Pierantoni eds., Monduzzi Editore, Bologna. 753-758 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anderson, W. G.: "Angiotensin and angiotensin receptors in cartilaginous fishes."Comp. Biochem. Physiol.. 128A. 31-40 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cerra, M. C., et al.: "Angiotensin II binding sites in the heart of Scyliorhinus cannicula : An autoradiographic study."Gen. Comp. Endocrinol.. 121. 126-134 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., et al.: "Antidipsogenic effect of eel bradykinin in the eel, Anguilla japonica."Am. J. Physiol.. 281. R1090-R1096 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakoshi, A., et al.: "CNP is the only natriuretic peptide in a elasmobranch fish, Triakis scyllia."Zool. Sci.. 18. 861-868 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y. and Tsukada, T.: "Ambient temperature regulates drinking rate and arterial pressure in eels."Zool. Sci.. 18. 963-967 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sekiguchi, T., et al.: "Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression."Gene. 273. 251-257 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsukada, T., and Takei, Y.: "Relative potency of three homologous natriuretic peptide (ANP, CNP and VNP) in eel osmoregulation."Zool. Sci.. 18. 1253-1258 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anderson, W. G., et al.: "The dipsogenic effect of the renin-angiotensin system in elasmobranch fish."Gen. Comp. Endocrinol.. 125. 300-307 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, A., et al.: "Identfication of a novel osteobalstic gene, Inducible by C-type natriuretic peptide, whose transcript might function in mineralization as a noncoding RNA."Calcif. Tissue Int.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anderson, W. G., et al.: "Osmotic and volemic effects on drinking rate in elasmobranch fish."J. Exp. Biol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y., and Hirose, S.: "The natriuretic peptide system in eel : a key endocrine system for euryhalinity?"Am. J. Physiol.. (invited review).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y.: "Hormonal control of drinking in the eel."Osmoregulation and Drinking in Aquatic and Terrestrial Vertebrates. N. Hazon and G. Flik eds., BIOS Scientific Publishers Limited, Oxford.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anderson, W. G.: "The Control of Drinking in Elasmobranch fish with special reference to the Renin Angiotensin System."Osmoregulation and Drinking in Aquatic and Terrestrial Vertebrates. N. Hazon and G. Flik eds., BIOS Scientific Publishers Limited, Oxford. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, K., and Takei, Y.: "Adaptability of medaka (Oryzias latipes) and three related species to environmental salinity."Zool. Sci.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li, Y. -Y., and Takei, Y.: "Effects of homologous natriuretic peptides on cortisol secretion in the eel, Anguilla japonica."J. Endocrinol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, K., Russell, M. J., Olson, K. R., and Takei, Y.: "C-type natriuretic peptide of rainbow trout (Oncorhynchus mykiss) : Primary structure and vasorelaxant activities."Gen. Comp. Endocrinol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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