1997 Fiscal Year Annual Research Report

分子標的治療の臨床応用へのアプローチ

Research Project

Project/Area Number	09255104
Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Nagoya City University
Principal Investigator	上田龍三名古屋市立大学, 医学部, 教授 (20142169)
Co-Investigator(Kenkyū-buntansha)	大野竜三浜松医科大学, 教授 (70093002) 花井陳雄協和醗酵工業株式会社, 主任研究員真弓忠範大阪大学, 薬学部, 教授 (00098485) 遠藤啓吾群馬大学, 医学部, 教授 (10115800) 山口俊晴京都府立医科大学, 助教授 (90111327)
Keywords	癌組織血管内皮細胞 / モノクローナル抗体 / ミサイル療法 / キメラ抗体 / 微少残存腫瘍(MRD) / 分化誘導療法 / 分子標的 / ADF / チオレドキシン
Research Abstract	1.抗体療法に関しては、 1)癌組織血管内皮細胞(TEC)に対するモノクローナル抗体TES-23の作成に成功。がん組織血管を標的としたミサイル療法の有用性が示唆された(真弓)。2)ガングリオシドGM2を認識するマウスモノクローナル抗体の遺伝子を単離し、コンピューターモデリングを利用してヒト化抗体を作成(花井)。3)キメラ抗体とネオカルチノスタチン複合体chA7-NCSの投与例における免疫反応を解析(山口)。4)Ph陽性急性リンパ性白血病のBMT後の再発に微少残存腫瘍(MRD)の持続的増加の関与が示された。悪性リンパ腫に対するCD34陽性造血幹細移植療法を検討した(上田)。5)I-131標識CD20抗体のin vitroならびに動物モデルの検討から、本治療法の有用性が示唆された(遠藤)。 2.分化誘導療法に関しては、 1)ホメオボックスB6、B9遺伝子の顆粒球系分化を明らかとした(大野)。2)白血病細胞の分化において、異なる二種類の分化誘導剤の併用により相乗効果をもたらすことを明らかにした(本間)。 3.化学療法剤の新規分子標的として、 1)ADF/チオレドキシン系の抗癌剤耐性への関与、アポトーシスに関係するCaspaseやp53の活性がレドックス制御をうけることを明らかとした(淀井)。2)MAPキナーゼ(MAPK)アンチセンス核酸投与による肺癌細胞の増殖抑制およびパクリタキセルの抗腫瘍作用増強効果をえた(西條)。

Research Products

(53 results)

All Other

All Publications (53 results)

[Publications] Nishida,K.: "In vitro effects of a recombinant toxin,mSCF-PE40,targeting c-kit receptors ectopically expressed in small cell lung cancers" Cancer Letters. 113. 153-158 (1997)
[Publications] Tanaka,K.: "Application of fluorescence in situ hybridization to detect residual leukemic cells with 9;22 and 15;17 translocations." Leukemia. 11. 436-440 (1997)
[Publications] Yuasa,H.: "Case-control study of leukemia and diagnostic radiation exposure" Inter.J.Hematol.65. 251-261 (1997)
[Publications] Ida,K.: "Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11q23 abnormalities" Medical and Pediatric Oncology. 28. 325-332 (1997)
[Publications] Goi,K.: "DNA damage-associated dysregulation of the cell-cycle and apoptosis control in cells with germ-line p53 mutation." Cancer Res.57. 1895-1902 (1997)
[Publications] Takeuchi,M.: "Re-induction of complete remission with a new synthetic retinoid,Am-80,for relapse of acute promyelocytic leukemia previously treated with all-trans retinoic acid" Brit.J.Haematol.97. 137-140 (1997)
[Publications] Ogura,M.: "Phase I/II trial of cure-oriented high-dose chemoradiotherapy with transplantation of CD34^+ peripheral blood stem cells purified by the immunomagnetic bead method for refractory hematological malignancies" Cancer Chemother.Pharmaco. 40. S51-S57 (1997)
[Publications] Kiyoi,H.: "Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocyti leukemia." Leukemia. 11. 1447-1452 (1997)
[Publications] Tobita,T.: "Treatment with a new synthetic retinoid,am80,of acute promyelocytic leukemia relapso from complete remission induced by all-trans retinoic acid" Blood. 90.3. 967-973 (1997)
[Publications] Suzuki,R.: "CD7^+ and CD56^+ myeloidd/natural killer cell precursor acute leukemia:a distinc hematolyphoid disease entity" Blood. 90.6. 2417-2428 (1997)
[Publications] Hanamura,I.: "Idiopathic CD4^+ T-lymphocytopenia in a non-Hodgkin's lymphoma patient Internal Medicine" Int.Medicine. 36.9. 643-646 (1997)
[Publications] Joh.T.: "Chimeric MLL products with a ras binding cytoplasmic protein AF6 involved in t(6;11)(q27;q23) leukemia localize in the nucleus" Oncogene. 15. 1681-1687 (1997)
[Publications] Nishi,H.: "Reduced blood accumulation of biotinylated monoclonal antibody A7 after,the subsequent administration of avid in." Cancer Letters. 120. 127-134 (1997)
[Publications] Kitamura,K.: "Chronologic changes in the clinicopathologic findings and survival of gastric cancer patients." J.Clin,Oncol.15. 3471-3480 (1997)
[Publications] Otsuji,E.: "Decreased renal accumulation of biotinylated chimeric monoclonal antibody-neocarzinostatin conjugate after adeministration of avid in" Jpn.J.Cancer Res.88. 205-212 (1997)
[Publications] Sakakura,C.: "Analysis of histological therapeutic effect,apoptosis rate and p53 status after combined treatmernt with radiation,hyperthermia and 5-fluorouracil suppositories for advanced rectal cancers" Brit.J.Cancer. 77. 159-166 (1997)
[Publications] Kitamura,K.: "Early gastric cancer mimicfling advanced gastric cancer" Brit.J.Cancer. 75. 1769-1773 (1997)
[Publications] Otsuji,E.: "End results of simultaneous pancreatectomy,splenectomy and total gastrectomy for patients with gastric carcinoma" Brit.J.Cancer. 75. 1219-1223 (1997)
[Publications] Stabin,M.G.: "Radiation dosimetry for indium-111-pentetreotide." J.Nucl.Med.38. 1919-1920 (1997)
[Publications] Hirano,T.: "Differentiating histologic malignancy of primary brain tumors:Pentavalent technetium-99r" J.Nucl.Med.38. 20-26 (1997)
[Publications] Sakahara,H.: "Anti-murine anitibody response to mouse monoclonal antibodies in cancer patients." Jpn.J.Cancer Res.88. 895-899 (1997)
[Publications] Ohizumi,I.: "Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats." Biochem.Biophys.Res.Commun.232. 493-496 (1997)
[Publications] Okada,N.: "Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L) lysine-alginate membrane" Biochem.Biophys Res.Commun.1360. 53-63 (1997)
[Publications] Tsutsumi,Y.: "PEGylation of interleukin-6 effectively increases its thrombopoietic potency" Thromb.Haemostas.77. 168-173 (1997)
[Publications] Okada,N.: "Medical application of microencapsulating hybridoma cells in agarose microbeads "Cytomedicine",Therapeutic effect on IgG1 plasmacytosis and mesangioproliferative glomerrulonephritis in the interleukin-6 transgenic mouse." J.Control.Release. 44. 195-200 (1997)
[Publications] Muzuguchi,H.: "Cytoplasmic gene expression system enhances the efficiency of cationic liposome-mediated in vivo gene transfer into mouse brain" Biochem.Biophys.Res.Commun.234. 15-18 (1997)
[Publications] Igarashi,R.: "Lecithinaization of IL-6 enhances its thrombopoietic activity" J.Pharm.Pharmacol. 49. 113-118 (1997)
[Publications] Teramoto,T.: "A novel type of calcium channel sensitive to w-agatoxin-TK in cultured rat cerebral cortical neurons" Brain Res.756. 225-230 (1997)
[Publications] Okada,N.: "Immunological studies of SK2 hybridoma cells microencapsulated with alginate-poly(lysine-alginate(APA) membrane following allogeneic transplantation" Biochem.Biophys.Res.Commun.230. 524-527 (1997)
[Publications] Tobita,T.: "Treatment with a new synthetic retinoid,Am80,of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid." Blood. 90.3. 967-973 (1997)
[Publications] Asou,N.: "All-trans retinoic acid therapy for newly diagnosed acute promyelocytic leukemia." Cancer Chemother Pharmacol. 40. S30-S35 (1997)
[Publications] Kitamura,K.: "Mutant AF-2 domain of PML-RAR α in retinoic acid-resistant NB4 cells:differentiation induced by RA is triggered directly through PML-RAR α and its down-regulation in acute promyelocytic leukemia." Leukemia. 11. 1950-1956 (1997)
[Publications] Syinjo,K.: "Erythropoietin receptor expression on human bone marrow erythroid precursor cells by a newly-devised quantitative flow-cytometric assay" Brit.J.Haematology. 96. 551-558 (1997)
[Publications] Miura,Y.: "Human urinary macrophage colony-stimulating factor reduces the incidence and durationof febrile neulropenia and shortens the period required to finish three courses of intensive consolidation therapy in acute myeloid leukemia double-blind controlled study" J.Clin.Oncology. 15.8. 2954-2065 (1997)
[Publications] Asou,N.: "All-trans retinoic acid therapy for newly diagnosed acute promyelocytic leukemia;comparison with intensive chemotherapy." Cancer Chemother Pharmacol. 10. S30-S35 (1997)
[Publications] Miyoshi,H.: "Glucocorticoids induce apoptosis in acute myeloid leukemaia cell lines with at (8;21)chromosome translocation" Leukemia Res.21. 45-50 (1997)
[Publications] Kasukabe,T.: "An anticancer derivative of butyric acid(pivalyloxymethy1 butyrate)and daunorubicin cooperatively prolongs surrival of of mice inoculated with monocytic leukemia cells" Brit.J.Cancer. 75. 850-854 (1997)
[Publications] Kasukabe,T.: "Tra-1,a novel mRNA highly expressed in leukemogenic mouse mouse monocytic sublines but not in nonleukemogenis sublines" Blood. 89. 2975-2985 (1997)
[Publications] Niitsu,N.: "Neplanocin A,a potent inhibitor of S-adenosylhomocysteine hydrolase,potentiates granulocytic differentiation of acute promyelocytic leukemia cells induced by all-trans retinoic acid" Exp.Hematol.25. 1296-1303 (1997)
[Publications] Niitsu,N.: "AML1a,but not AML1b,inhibits erythroid defferentiation induced by sodium butyrate and enhances megakaryocytic differentiation of K562 leukemia cells" Cell Growth Differen.8. 319-326 (1997)
[Publications] Hirota,K.: "AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1." Proc.Natl.Acad.Sci.USA. 94. 3633-3638 (1997)
[Publications] Iwata,S.: "ATL-Derived Factor(ADF)/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion. Possible involvement of Thiol-mediated redox regulation in apoptosis caused by pro-oxidant state." J.Immunol.158. 3108-3117 (1997)
[Publications] Nakamura,H.: "Redox regulation of cellular activation" Annu.Rev.Immunol.15. 351-369 (1997)
[Publications] Furuke,K.: "Role of intracellular redox status in apoptosis induction of HTLV-infected lymphocytes by retinoic acid." Cancer Res.57. 4916-4923 (1997)
[Publications] Yamamoto,M.: "Induction of human thioredoxin in cultured human retinal pigment epithelial cells though cyclic AMP-dependent pathway:involvement in the cytoprotective activity of prostaglandin EI" Exp.Eye Res.65. 645-652 (1997)
[Publications] Akamatsu,Y.: "Redox regulation of the DNA binding activity in transcription factor PEBP2:The roles of two concerved cysteine residues" J.Biol.Chemotherapy. 272. 14497-14500 (1997)
[Publications] Ishida,T.: "Circumvention of glutathione-mediated mitomycin C-resistance by a mitomycin C analogue(KW-2149)." Int.J.Cancer. 72. 865-870 (1997)
[Publications] Fukuoka,K.: "p16INK4 expression is associated with the increased sensitivity of human non-small cell lung cancer cells to DNA topoisomerase Winhibitors" Jpn.J.Cancer Res.88. 1009-1016 (1997)
[Publications] Kurokawa,H.: "Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the & gamma;-glutamylcysteine synthetase gene" Jpn.J.Cancer Res.88. 108-110 (1997)
[Publications] Kanzawa,F.: "Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line,SBC-" Int.J.Cancer. 71. 311-319 (1997)
[Publications] Kanzawa,F.: "In vitro interaction between gemcitabine and other anticancer drug suing a novel three-dimensional model" Semin.Oncol.24. S7-8-S7-16 (1997)
[Publications] Arioka,H.: "In vitro and in vivo modulation by rhizoxin of non-p-glycoprotein-mediated vindesine resistance" J.Cancer Res.Clin.Oncol.123. 195-200 (1997)
[Publications] Ogasawara,H.: "In vitro enhancement of a water-soluble duocarmycin-derivative,KW-2189 antitumor activity by caffeine-meiated DNA-repair inhibition in a human lung cancer cells" Jpn.J.Cancer Res.88. 1033-1037 (1997)

1997 Fiscal Year Annual Research Report

分子標的治療の臨床応用へのアプローチ

Principal Investigator

上田 龍三 名古屋市立大学, 医学部, 教授 (20142169)

Research Products

[Publications] Nishida,K.: "In vitro effects of a recombinant toxin,mSCF-PE40,targeting c-kit receptors ectopically expressed in small cell lung cancers" Cancer Letters. 113. 153-158 (1997)

[Publications] Tanaka,K.: "Application of fluorescence in situ hybridization to detect residual leukemic cells with 9;22 and 15;17 translocations." Leukemia. 11. 436-440 (1997)

[Publications] Yuasa,H.: "Case-control study of leukemia and diagnostic radiation exposure" Inter.J.Hematol.65. 251-261 (1997)

[Publications] Ida,K.: "Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11q23 abnormalities" Medical and Pediatric Oncology. 28. 325-332 (1997)

[Publications] Goi,K.: "DNA damage-associated dysregulation of the cell-cycle and apoptosis control in cells with germ-line p53 mutation." Cancer Res.57. 1895-1902 (1997)

[Publications] Takeuchi,M.: "Re-induction of complete remission with a new synthetic retinoid,Am-80,for relapse of acute promyelocytic leukemia previously treated with all-trans retinoic acid" Brit.J.Haematol.97. 137-140 (1997)

[Publications] Ogura,M.: "Phase I/II trial of cure-oriented high-dose chemoradiotherapy with transplantation of CD34^+ peripheral blood stem cells purified by the immunomagnetic bead method for refractory hematological malignancies" Cancer Chemother.Pharmaco. 40. S51-S57 (1997)

[Publications] Kiyoi,H.: "Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocyti leukemia." Leukemia. 11. 1447-1452 (1997)

[Publications] Tobita,T.: "Treatment with a new synthetic retinoid,am80,of acute promyelocytic leukemia relapso from complete remission induced by all-trans retinoic acid" Blood. 90.3. 967-973 (1997)

[Publications] Suzuki,R.: "CD7^+ and CD56^+ myeloidd/natural killer cell precursor acute leukemia:a distinc hematolyphoid disease entity" Blood. 90.6. 2417-2428 (1997)

[Publications] Hanamura,I.: "Idiopathic CD4^+ T-lymphocytopenia in a non-Hodgkin's lymphoma patient Internal Medicine" Int.Medicine. 36.9. 643-646 (1997)

[Publications] Joh.T.: "Chimeric MLL products with a ras binding cytoplasmic protein AF6 involved in t(6;11)(q27;q23) leukemia localize in the nucleus" Oncogene. 15. 1681-1687 (1997)

[Publications] Nishi,H.: "Reduced blood accumulation of biotinylated monoclonal antibody A7 after,the subsequent administration of avid in." Cancer Letters. 120. 127-134 (1997)

[Publications] Kitamura,K.: "Chronologic changes in the clinicopathologic findings and survival of gastric cancer patients." J.Clin,Oncol.15. 3471-3480 (1997)

[Publications] Otsuji,E.: "Decreased renal accumulation of biotinylated chimeric monoclonal antibody-neocarzinostatin conjugate after adeministration of avid in" Jpn.J.Cancer Res.88. 205-212 (1997)

[Publications] Sakakura,C.: "Analysis of histological therapeutic effect,apoptosis rate and p53 status after combined treatmernt with radiation,hyperthermia and 5-fluorouracil suppositories for advanced rectal cancers" Brit.J.Cancer. 77. 159-166 (1997)

[Publications] Kitamura,K.: "Early gastric cancer mimicfling advanced gastric cancer" Brit.J.Cancer. 75. 1769-1773 (1997)

[Publications] Otsuji,E.: "End results of simultaneous pancreatectomy,splenectomy and total gastrectomy for patients with gastric carcinoma" Brit.J.Cancer. 75. 1219-1223 (1997)

[Publications] Stabin,M.G.: "Radiation dosimetry for indium-111-pentetreotide." J.Nucl.Med.38. 1919-1920 (1997)

[Publications] Hirano,T.: "Differentiating histologic malignancy of primary brain tumors:Pentavalent technetium-99r" J.Nucl.Med.38. 20-26 (1997)

[Publications] Sakahara,H.: "Anti-murine anitibody response to mouse monoclonal antibodies in cancer patients." Jpn.J.Cancer Res.88. 895-899 (1997)

[Publications] Ohizumi,I.: "Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats." Biochem.Biophys.Res.Commun.232. 493-496 (1997)

[Publications] Okada,N.: "Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L) lysine-alginate membrane" Biochem.Biophys Res.Commun.1360. 53-63 (1997)

[Publications] Tsutsumi,Y.: "PEGylation of interleukin-6 effectively increases its thrombopoietic potency" Thromb.Haemostas.77. 168-173 (1997)

[Publications] Okada,N.: "Medical application of microencapsulating hybridoma cells in agarose microbeads "Cytomedicine",Therapeutic effect on IgG1 plasmacytosis and mesangioproliferative glomerrulonephritis in the interleukin-6 transgenic mouse." J.Control.Release. 44. 195-200 (1997)

[Publications] Muzuguchi,H.: "Cytoplasmic gene expression system enhances the efficiency of cationic liposome-mediated in vivo gene transfer into mouse brain" Biochem.Biophys.Res.Commun.234. 15-18 (1997)

[Publications] Igarashi,R.: "Lecithinaization of IL-6 enhances its thrombopoietic activity" J.Pharm.Pharmacol. 49. 113-118 (1997)

[Publications] Teramoto,T.: "A novel type of calcium channel sensitive to w-agatoxin-TK in cultured rat cerebral cortical neurons" Brain Res.756. 225-230 (1997)

[Publications] Okada,N.: "Immunological studies of SK2 hybridoma cells microencapsulated with alginate-poly(lysine-alginate(APA) membrane following allogeneic transplantation" Biochem.Biophys.Res.Commun.230. 524-527 (1997)

[Publications] Tobita,T.: "Treatment with a new synthetic retinoid,Am80,of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid." Blood. 90.3. 967-973 (1997)

[Publications] Asou,N.: "All-trans retinoic acid therapy for newly diagnosed acute promyelocytic leukemia." Cancer Chemother Pharmacol. 40. S30-S35 (1997)

[Publications] Kitamura,K.: "Mutant AF-2 domain of PML-RAR α in retinoic acid-resistant NB4 cells:differentiation induced by RA is triggered directly through PML-RAR α and its down-regulation in acute promyelocytic leukemia." Leukemia. 11. 1950-1956 (1997)

[Publications] Syinjo,K.: "Erythropoietin receptor expression on human bone marrow erythroid precursor cells by a newly-devised quantitative flow-cytometric assay" Brit.J.Haematology. 96. 551-558 (1997)

[Publications] Asou,N.: "All-trans retinoic acid therapy for newly diagnosed acute promyelocytic leukemia;comparison with intensive chemotherapy." Cancer Chemother Pharmacol. 10. S30-S35 (1997)

[Publications] Miyoshi,H.: "Glucocorticoids induce apoptosis in acute myeloid leukemaia cell lines with at (8;21)chromosome translocation" Leukemia Res.21. 45-50 (1997)

[Publications] Kasukabe,T.: "An anticancer derivative of butyric acid(pivalyloxymethy1 butyrate)and daunorubicin cooperatively prolongs surrival of of mice inoculated with monocytic leukemia cells" Brit.J.Cancer. 75. 850-854 (1997)

[Publications] Kasukabe,T.: "Tra-1,a novel mRNA highly expressed in leukemogenic mouse mouse monocytic sublines but not in nonleukemogenis sublines" Blood. 89. 2975-2985 (1997)

[Publications] Niitsu,N.: "Neplanocin A,a potent inhibitor of S-adenosylhomocysteine hydrolase,potentiates granulocytic differentiation of acute promyelocytic leukemia cells induced by all-trans retinoic acid" Exp.Hematol.25. 1296-1303 (1997)

[Publications] Niitsu,N.: "AML1a,but not AML1b,inhibits erythroid defferentiation induced by sodium butyrate and enhances megakaryocytic differentiation of K562 leukemia cells" Cell Growth Differen.8. 319-326 (1997)

[Publications] Hirota,K.: "AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1." Proc.Natl.Acad.Sci.USA. 94. 3633-3638 (1997)

[Publications] Iwata,S.: "ATL-Derived Factor(ADF)/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion. Possible involvement of Thiol-mediated redox regulation in apoptosis caused by pro-oxidant state." J.Immunol.158. 3108-3117 (1997)

[Publications] Nakamura,H.: "Redox regulation of cellular activation" Annu.Rev.Immunol.15. 351-369 (1997)

[Publications] Furuke,K.: "Role of intracellular redox status in apoptosis induction of HTLV-infected lymphocytes by retinoic acid." Cancer Res.57. 4916-4923 (1997)

[Publications] Yamamoto,M.: "Induction of human thioredoxin in cultured human retinal pigment epithelial cells though cyclic AMP-dependent pathway:involvement in the cytoprotective activity of prostaglandin EI" Exp.Eye Res.65. 645-652 (1997)

[Publications] Akamatsu,Y.: "Redox regulation of the DNA binding activity in transcription factor PEBP2:The roles of two concerved cysteine residues" J.Biol.Chemotherapy. 272. 14497-14500 (1997)

[Publications] Ishida,T.: "Circumvention of glutathione-mediated mitomycin C-resistance by a mitomycin C analogue(KW-2149)." Int.J.Cancer. 72. 865-870 (1997)

[Publications] Fukuoka,K.: "p16INK4 expression is associated with the increased sensitivity of human non-small cell lung cancer cells to DNA topoisomerase Winhibitors" Jpn.J.Cancer Res.88. 1009-1016 (1997)

[Publications] Kurokawa,H.: "Effect of glutathione depletion on cisplatin resistance in cancer cells transfected with the & gamma;-glutamylcysteine synthetase gene" Jpn.J.Cancer Res.88. 108-110 (1997)

[Publications] Kanzawa,F.: "Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line,SBC-" Int.J.Cancer. 71. 311-319 (1997)

[Publications] Kanzawa,F.: "In vitro interaction between gemcitabine and other anticancer drug suing a novel three-dimensional model" Semin.Oncol.24. S7-8-S7-16 (1997)

[Publications] Arioka,H.: "In vitro and in vivo modulation by rhizoxin of non-p-glycoprotein-mediated vindesine resistance" J.Cancer Res.Clin.Oncol.123. 195-200 (1997)

[Publications] Ogasawara,H.: "In vitro enhancement of a water-soluble duocarmycin-derivative,KW-2189 antitumor activity by caffeine-meiated DNA-repair inhibition in a human lung cancer cells" Jpn.J.Cancer Res.88. 1033-1037 (1997)

上田龍三名古屋市立大学, 医学部, 教授 (20142169)