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2001 Fiscal Year Final Research Report Summary

Regulation of cellular Function by molecular chaperones

Research Project

Project/Area Number 09276102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

NAGATA Kazuhiro  Kyoto Univ., Inst. for Frontier Medical Sciences, Professor, 再生医科学研究所, 教授 (50127114)

Co-Investigator(Kenkyū-buntansha) ITO Koreaki  Kyoto Univ., Inst. for Virus Research, Professor, ウイルス研究所, 教授 (90027334)
MORI Masataka  Kumamoto Univ., School of Medicine, Professor, 医学部, 教授 (40009650)
YOSHIDA Masasuke  Chemical Res. Lab. Tokyo Inst. of Technology, Professor, 資源化学研究所, 教授 (90049073)
ENDO Toshiya  Nagoya Univ., Graduate School of Science, Professor, 大学院・理学研究科, 教授 (70152014)
MIHARA Katsuyoshi  Kyushu Univ., Graduate Sch. of Med. Sch. of Med. Sci., Professor, 大学院・医学研究科, 教授 (40029963)
Project Period (FY) 1997 – 2001
Keywordsmolecular chaperone / stress proteins / protein folding / quality control / heat shock proteins / chaperonin / transport / prion
Research Abstract

This group tried to well-organize the studies performed among three groups : "Dynamic interaction between chaperone and its substrates", "Roles of molecular chaperones in cell function" and the selected research groups from applicants.
1. We held the group meeting twice a year and discussed about the progress of each research as well as perspective and direction of the whole research groups.
2. We issued the "Chaperone newsletter" twice a year to stimulate the exchange of the information among the members. In addition to the 9 issues of these newsletters, we also published a special issue on "Chaperone-related ATPases". These newsletters brought broad interest and impact to general readers outside this field.
3. We organized a general meeting for all the members every year and active discussion was performed on the progress of each research by the attendants including the members.
4. We organized a international congress titled "Molecular Chaperone 2000" in Tokyo and two symposiums and two workshops during these 5 years.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Taguchi, H., et al.: "Shingle-molecule observation of protein-protein interactions in the chaperonin system"Nat.Biotechnol.. 19. 861-865 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishikawa, S., et al.: "Molecular chaperones in the yeast ER maintain the solubility of proteins for retro-translocation and degradation"J.Cell Biol.. 153. 1061-1039 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosokawa, N., et al.: "A novel ER α-mannosidase-like protein accelerates ER-associated degradation"EMBO Reports. 2. 415-422 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi, T., et al.: "Respiratory chain strongly oxidizes the CXXC motif of DsbB in the Escherichia coli disulfide-bond formation pathway"EMBO J.. 18. 1192-1198 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ota, K., et al.: "Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning menbrane proteins"Molecular Cell. 2. 495-503 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terada, K., et al.: "The human Dna J homologue dj2 facilitates mitochondrial protein import and luciferase refolding"J.Cell Biol.. 139. 1089-1095 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永田和宏, 森正敬, 吉田賢右: "分子シャペロンによる細胞機能制御"シュプリンガー・フェアラーク東京. 219 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taguchi,H.,et al.: "Shingle-molecule observation of protein-protein interactions in the chaperonin system."Nat. Biotechnol.. 19. 861-865 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishikawa,S.,et al.: "Molecular chaperones in the yeast ER maintain the solubility of proteins for retro-translocation and degradation."J. Cell Biol.. 153. 1061-1039 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosokawa,N.,et al.: "A novel ER α-mannosidase-like protein accelerates ER-associated degradation."EMBO Reports. 2. 415-422 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi,T.,et al.: "Respiratory chain strongly oxidizes the CXXC motif of DsbB in the Escherichia coli disulfide-bond formation pathway."EMBO J.. 18. 1192-1198 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ota,K.,et al.: "Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning menbrane proteins."Molecular Cell. 2. 495-503 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terada,K.,et al.: "The human Dna J homologue dj2 facilitates mitochondrial protein import and luciferase refolding."J. Cell Biol.. 139. 1089-1095 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eds.Nagata,K.,Mori,M.,Yoshida,M.: "Regulation of cellular function by molecular chaperones."Springer-Verlag Tokyo. 219 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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