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1999 Fiscal Year Final Research Report Summary

Mechanism of stress reaction in the central nervous system and effects on immune function

Research Project

Project/Area Number 09307007
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

TAKAHASHI Kyoko  School of Medicine, Hokkaido Univ., Inst., 医学部, 助手 (50292008)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Toshiyuki  Center for Res. And Develop. In Higher Edu., Hokkaido Univ., Asso. Pro., 高等教育機能開発総合センター, 助教授 (00157025)
SAITO Takeshi  School of Medicine, Hokkaido Univ., Asso. Prof., 医学部, 助教授 (40153811)
SAITO Kazuo  Hokkaldo Univ., Professor Emeritus, 名誉教授 (80000917)
SHIDO Koichi  School of Medicine, Hokkaido Univ., Inst., 医学部, 助手 (20206098)
KURASAKI Masaaki  Grad. School of Env. Earth Sci., Hokkaido Univ., Inst., 大学院・地球環境科学研究科, 助手 (80161727)
Project Period (FY) 1997 – 1999
Keywordsstress / immune function / Anaerobic Threshold / VDT work / combined effects / zinc / White Blood Cells / Diabetes Mellitus
Research Abstract

In the present study, we intended to evaluate the mechanism of stress reaction in the central nervous system and effects of stress on immune function. Results obtained in the present investigations are as follows ;
1. Mechanism of stress reaction in the central nervous system
1) We determined different exercise intensities with the anaerobic threshold (AT) as the standard on electroencephalograph and heart rate variability. The results suggest that exercise intensity 20% less than one's AT level has good effects on one's health.
2) We determined combined effects of city noise and the luminance of computer display on human subjects. The results showed high luminance with noise had the greatest effects on subjective fatigue and mental activities.
2. Effects of stress on immune function
1) We determined the effects of physical stress on immune function in rats. The results indicate that the effect of stress on immune function depends on the intensity of stress.
2) We determined zinc concentrations in leukocytes of healthy subjects and patients with NIDDM, one of stress related diseases. There was a significant difference in the zinc concentrations of leukocytes between healthy subjects and patients with NIDDM.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 高橋恭子: "簡便な疲労調査票による労働者の疲労調査"北方産業衛生. 42. 1-5 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木浩子: "騒音と画面輝度の複合要因によるVDT作業者の生理機能への影響"北方産業衛生. 42. 11-17 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeshi Saito: "Immunohistochemical determination of the Wilson Copper-transporting P-type ATPase in the brain tissues of the rat"Neuroscience Letters. 266. 13-16 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高橋恭子: "疲労負荷が免疫系に及ぼす影響"北海道医学雑誌. 73. 61-71 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木浩子: "Anaerobic Thresholdを基準とした運動強度の脳波及び心電図R-R間隔変動に及ぼす影響"北海道医学雑誌. 73. 327-341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高倉昌之: "白血球中亜鉛濃度測定法の確立と糖尿病患者への応用"北海道医学雑誌. 73. 571-580 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 齋藤和雄: "健康の科学シリーズ6 栄養・運動・休養"日本栄養・食糧学会監修,糸川嘉則・弓狩康三編 学会センター関西. (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeshi Saito: ""Trace Elements in Man and Animal Vol 10 "(Ed.)"Plenum Publishing (New York) (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Takahashi, T. Saito, K. Saito: "A trial to evaluate workers' fatigue using a simplified questionnaire"J Nor Occ Health. 42. 1-5 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Sasaki, K. Takahashi, T. Saito, T. Hosokawa, K. Saito: "Combined effects of city noise and luminance on physiological status in VDT work"J Nor Occ Health. 42. 11-17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Saito, M. Okabe, T. Hosokawa, M. Kurasaki, et al: "Immunohistochemical determination of the Wilson Copper-transporting P-type ATPase in the brain tissue of the rat"Neurosci Lett. 266. 13-16 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Takahashi: "Effects of physical exhaustion on immune systems"Hokkaido J Med Sci. 73. 61-71 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Sasaki: "Effects of the exercise intensities standardized by anaerobic threshold on EEG and heart rate variability"Hokkaido J Med Sci. 73. 327-341 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Takakura: "Analysis of zinc concentrations in leukocytes and its application to patients with Non-insulin-dependent Diabetes Mellitus"Hokkaido J Med Sci. 73. 571-580 (1998)

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      「研究成果報告書概要(欧文)」より
  • [Publications] K. Saito: "Series of health science 6"Nutrition, exercise, rest. (1998)

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      「研究成果報告書概要(欧文)」より
  • [Publications] T. Saito, N. Nakagawa, K. Takahashi, D. Li, et al: "Zinc-induced excessive glutamate releases may cause accelerated senescence with defect in learning and memory in senescence acceleratedmouse Trace Elements in Man and Animal 10 Eds. Favier,, A., Anderson. R.A., Roussel A.M."Plenum Publishing Co., New York(in press). (2000)

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      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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