1998 Fiscal Year Final Research Report Summary
Quantitative analysis of neuronal density in Alzheimer's disease by MR axonography
| Project/Area Number |
09307012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
NAKADA Tsutomu Niigata University Brain Research Institute Professor, 脳研究所, 教授 (50281720)
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| Co-Investigator(Kenkyū-buntansha) |
SOMA Yoshiaki Niigata University Brain Research Institute Associate Professor, 脳研究所, 助教授 (30163132)
TSUJI Shoji Niigata University Brain Research Institute Professor, 脳研究所, 教授 (70150612)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Alzheimer's disease / MRI / diffusion-weighted image / axonography |
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| Research Abstract |
Among the various contrast mechanics for magnetic resonance (MR) imaging, apparent diffusion possesses the unique property of directional dependency (anisotropic diffusion), In the central nervous system, anisotropism has empirically been shown to primarily originate from axons. It is therefore possible to obtain axonal information in vivo by diffusion tensor analysis, non-invasively, in humans (axonography). The project represents clinical applications of this axonographic method in attempt to obtain further insight into the pathophysiology of degenerative neurological disorders such as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. The project has successfully introduced various techniques in axonography and clearly demonstrates that quantitative analysis of fast axonal flow is now feasible in humans.
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