• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1999 Fiscal Year Final Research Report Summary

Non-invasive study on sensorimotor Integration in human gait

Research Project

Project/Area Number 09308031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIBASAKI Hiroshi  Kyoto University, Brain Pathophysiology, Professor, 医学研究科, 教授 (30037444)

Co-Investigator(Kenkyū-buntansha) IKEDA Akio  Kyoto University, Brain Pathophysiology, Associate Professor, 医学研究科, 助手 (90212761)
NAGAMINE Takashi  Kyoto University, Brain Pathophysiology, Associate Professor, 医学研究科, 助手 (10231490)
FUKUYAMA Hidenao  Kyoto University, Brain Pathophysiology, Associate Professor, 医学研究科, 助教授 (90181297)
Project Period (FY) 1997 – 1999
KeywordsGait / Sensorimotor integration / Visual stimulus / Cerebral blood flow / SPECT / MEG / Station
Research Abstract

Ample clinical evidence has indicated that visual information processing plays en essential role in the sensorimotor integration during gait, although the underlying neural mechanisms are scarcely understood. In the recent three years, we have shown that neural system being composed of the lateral premotor-parietal cortex and cerebellum participates in visuomotor integration in gait and relates to the development of paradoxical movement in Parkinson's disease.
Using single photon emission computed tomography (SPECT), we investigated regional cerebral blood flow changes (rCBF) induced by station, gait and visually guided gait in patients with Parkinson's disease and age-matched control subjects. Task-related rCBF images were obtained by injecting ィイD199mィエD1Tc radiotracers during the task performance. Task-related brain activation was determined by statistical parametric mapping. Station-related activation in elderly subjects was observed in the supplementary motor area (SMA), foot prima … More ry motor areas (foot M1), visual cortex, and cerebellar vermis. During gait on a treadmill, elderly subjects showed activation in large mediodorsal frontoparietal areas including SMA and foot M1, visual cortex, dorsal brainstem and cerebellum. In parkinsonian patients, gait-related activation was reduced in the rostral SMA and cerebellar hemisphere, compared with the controls. During gait under visual guidance that improved parkinsonian gait, parkinsonian patients showed enhanced activation in the lateral premotor-parietal cortex and cerebellum. The findings suggest that the lateral premotor cortex, relatively well preserved in function in parkinsonian patients, may undertake the impaired SMA function in gait under the special condition.
Using magnetoencephalograpy (MEG), we examined temporal characteristics of visual evoked signals during motor or nonmotor tasks. The simple visual evoked magnetic responses in the frontal lobe were enhanced in the attention-requiring conditions, suggesting the context-dependent modulation of the frontal visual response. Less

  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Hanakawa, T. et al.: "Enhanced lateral remotor activity during paradoxical gait in Parkinson's desease"Ann. Neurol.. 45. 329-336 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terada,K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hamono,T. et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-515 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishitani,T. et al: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J.Neurosci.. 19. 2647-2657 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toma,K. et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study"J.Neurosci.. 19. 3527-3534 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda,A. et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of descrimination/selection-related potentials"Brain. 122. 915-931 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mima,T. et al.: "Somesthetic function of supplementary motor area during voluntary movements"NeuroReport. 10. 1859-1862 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanakawa,T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study"Brain. 122. 1271-1282 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yazawa,S. et al.: "Abnormal corticl processing of voluntary muscle relaxation in patients with focal hand dystoia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimazu,H. et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"NeuroReport. 10. 2457-2460 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mima,T. et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-1997 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanda,M. et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murase,N. et al.: "Abnormal premovement gating of somatosensory input in wrier's cramp"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yazawa,S. et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda,A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kunieda,T. et al.: "Different activation of pre-supplementary motor srea(pre-SMA), SMA proper and premary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanakawa, T. et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease."Ann. Neurol.. 45. 329-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terada, K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles."Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamano, T. et al.: "Abnormal contingent negative variation in writer's cramp."Clin. Neurophysiol.. 110. 508-15 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishitani, N. et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit."J. Neurosci.. 19. 2647-2657 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toma, K., et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study."J. Neurosci.. 19. 3527-3534 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, A., et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials."Brain. 122. 915-931 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mima, T. et al.: "Somesthetic function of supplementary motor area during voluntary movements."NeuroReport. 10. 1859-1862 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanakawa, T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study."Brain. 122. 1271-1282 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yazawa, S. et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials."Brain. 122. 1357-1366 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimazu, H. et al.: "Pre-movement gating of short-latency somatosensory evoked potentials."NeuroReport. 10. 2457-2460 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mima, T., et al.: "Brain structures related to active and passive finger movements in man."Brain. 122. 1989-1997 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanda, M., et al.: "Primary somatosensory cortex is actively involved in pain processing in human."Brain Res.. 853. 282-289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murase, N., et al.: "Abnormal premovement gating of somatosensory input in writer's cramp."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yazawa, S. et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex."Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kunieda, T. et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans."Exp. Brain Res. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2001-10-23  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi