| Project/Area Number |
09440230
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
MATSUDA Hideki Nagoya Institute of Technology, Dept. Applied Chemistry, Professor, 工学部, 教授 (50209441)
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Tomohiro Institute for Molecular Science, Coordination Chemistry Lab., Research Assistant, 分子科学研究所, 助手 (70270999)
JITSUKAWA Koichiro Nagoya Institute of Technology, Dept. Applied Chemistry, Associate Professor, 工学部, 助教授 (50235793)
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| Project Period (FY) |
1997 – 1999
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| Keywords | small molecule activation / Oxygen species / Amino acids / Self-organization / Unique reaction system / Non-covalent interaction / Non-heme enzyme model |
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| Research Abstract |
Some novel structural and/or functional model complexes for metalloenzymes were constructed, which have synthetically coordinated non-covalent interaction groups such as hydrogen bonding, hydrophobic, electrostatic, and π-π stacking interactions. 1. Fundamental analysis of such weak interactions were studied and the principle of self-organization was examined. 2. The metal complexes that enable to recognize amino acids and peptides were constructed as a peptidase model. 3. Transamination was examined by the use of Co(III)-pyridoxal-amino acids under non-enzymatic conditions. 4. Carbonic anhydrase model was constructed by the use of Zn(II)-polypyridylamine ligands. 5. The organic compounds recognizing and capturing the biologically essential metal elements were prepared. 6. The oxidase models that enable to recognize and activate oxygen species were constructed and some reaction intermediates with oxygen species were prepared and examined physico-chemically. 7. Hydrogenase models were synthesized by the use of Ni(II)-NィイD22ィエD2SィイD22ィエD2 complexes that regulate the redox potential.
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