| Co-Investigator(Kenkyū-buntansha) |
UJIIE Hiroshi Tokyo Women's Medical University, Neurosurgery, Research Associate, 脳神経外科, 助手 (00138869)
KUDO Susumu Shibaura Institute of Technology, Mechanical Engineering, Research Associate, 工学部, 助手 (70306926)
TSUNODA Kazumi Shibaura Institute of Technology, Mechanical Engineering, Lecturer, 工学部, 講師 (70255644)
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| Research Abstract |
The vascular disease such as the atherosclerosis and the aneurysm is apt to initiate around the aortic arch, the arterial branch of the intracranial artery and the abdominal aorta where the now pattern suddenly changes. In order to investigate the hemodynamic effect on arterial wall, it is necessary to clarify the distribution of wall shear stress. Also, it is biologically necessary to study the effect of wall shear stress and its gradient on arterial wall cell. In the present project, the wall shear stress in the model arterial branch and the anterior communicating artery have been measured by the electrochemical method in steady flow. In pulsating flow, the velocity profile is measured using Laser Doppler velocimeter, and the wall shear stress is also calculated from the velocity near tube wall. Furthermore, the effect of wall shear stress on the endothelial cell which locates at the interface between the blood flow and arterial wall is biologically investigated.
First, the wall shear stress is measured in the right angle branch model which the side branch bifurcates from the trunk with the round upstream corner. The wall shear stress around the upstream corner of side branch varies with large amplitude. Second, the flow pattern around the anterior communicating artery, which is the one of predilection regions of the saccular aneurysm, is visualized using the light sheet. The now pattern is characterized around the flow divider at the entrance of anterior communicating artery. Third, the shape and the uptake of albumin like the low density lipoprotein to endothelial cell was measured by the confocal microscope in back step now field. Around the reattachment point, the endothelial cell elongates and the uptake of albumin is higher than another region.
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