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1999 Fiscal Year Final Research Report Summary

Sensor mechanism and central pathway for hepatoportal NaィイD1+ィエD1 receptor

Research Project

Project/Area Number 09470008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionGifu University

Principal Investigator

MORITA Hironobu  Gifu University, School of Medicine, Physiology, Professor, 医学部, 教授 (80145044)

Co-Investigator(Kenkyū-buntansha) WATANABE Kazuko  Gifu University, School of Medicine, Physiology, Associate Professor, 医学部, 講師 (40158621)
LEE Ken  Gifu University, School of Medicine, Physiology, Associate Professor, 医学部, 助教授 (00212316)
Project Period (FY) 1997 – 1999
Keywordshepatoportal NaィイD1+ィエD1 and KィイD1+ィエD1 receptors / NaィイD1+ィエD1 and KィイD1+ィエD1 homeostasis / NaィイD1+ィエD1 KィイD1+ィエD1 2ClィイD1-ィエD1 contransporter / urinary NaィイD1+ィエD1 and KィイD1+ィエD1 excretion / hepatic nerve / central projection / Fos protein / bumetanide
Research Abstract

Recently, we demonstrated that the hepatoportal NaィイD1+ィエD1-sensitive mechanism plays a significant role in maintaining body fluid homeostasis by controlling renal excretory and jejunal absorptive functions. The afferent pathway of the hepatic body fluid control system is the periarterial hepatic nerve and efferent pathways are the renal sympathetic nerve and cholinergic fibers to the jejunum. However the sensor mechanisms and central pathways are still unknown. Accordingly, the purposes of the present study was to examine these two points and the following conclusions were obtained:
(1) The hepatoportal NaィイD1+ィエD1-receptive signals projects to the brain stem, hypothalamus, and forebrain structures involved in autonomic function and osmoregulation, then activate the fluid-regulatory mechanism. However, the hepatoportal osmoreceptive signals do not activate these central structures.
(2) The hepatoportal NaィイD1+ィエD1 receptor senses the NaィイD1+ィエD1 concentration via the bumetanide-sensitiv … More e NaィイD1+ィエD1 KィイD1+ィエD1 2ClィイD1-ィエD1 cotransporter.
(3) The hepatoportal bumetanide-sensitive NaィイD1+ィエD1 KィイD1+ィエD1 2ClィイD1-ィエD1 cotransporter also participate in the KィイD1+ィエD1-sensitive mechanism. When this mechanism is stimulated, kaliuresis occurs via the periarterial hepatic nervous plexus. Thus, the hepatoportal bumetanide-sensitive KィイD1+ィエD1-sensor mechanism may play an important role in regulating extracellular KィイD1+ィエD1 homeostasis.
The hepatoportal NaィイD1+ィエD1- and KィイD1+ィエD1-sensor mechanisms would be triggered by an increase in the portal venous NaィイD1+ィエD1 and KィイD1+ィエD1 concentrations in advance of changes in the systemic blood NaィイD1+ィエD1 and KィイD1+ィエD1 concentrations and reflexively regulate NaィイD1+ィエD1 and KィイD1+ィエD1 excretion. The important feature of this system is that the portal venous blood flow is 20〜25 % of cardiac output and the concentration of ions and the changes therein are therefore 4-5-times greater than in the systemic circulation. If the purpose of this system is to regulate the systemic blood NaィイD1+ィエD1 and KィイD1+ィエD1 concentrations, but not the portal venous NaィイD1+ィエD1 and KィイD1+ィエD1 concentrations, it would be operated by predicting the systemic blood concentrations from the portal venous concentrations and such prediction can result in errors of regulation. This control error would be corrected by other negative feedback systems. Less

  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Morita H, et al.: "Fos induction in rat brain neurons following stimulation of the hepatoportal Na-sensitive mechanism"AmericanJournal of Physiology. 272. 913-923 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsunooka K, Morita H: "Effect of a chronic high-salt diet on whole-body and organ sodium contents of Dahl rats"Journal of Hypertension. 15. 851-856 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishida Y, Morita H, et al.: "Suppression of renal sympathetic nerve activity during portal vein infusion of hypertonic saline"AmericanJournal of Physiology. 274. R97-R103 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murakami H, Morita H, et al.: "Blockade of neural nitric oxide synthase alters the baroreflex control of heart rate in the rabbit"AmericanJournal of Physiology. 274. R181-R186 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okada K, Morita H, et al.: "Role of endogenous endothelin in the development of graft arteriosclerosis in rat cardiac allografts"Circulation. 97. 2346-2351 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita H, et al.: "Role of the liver in long-term control of drinking behavior, Na balance and arterial pressure in Dahl rats"AmericanJournal of Physiology. 274. R1111-R1118 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugimoto I, Morita H er al.: "The gain of the hepatorenal reflex in anesthetized dogs"Journal of Auronomic Nervous System. 68. 164-170 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chen QH, Morita H er al.: "Organ and development related difference in tissue norepinephrine concentrations in Dahl rats"Journal of Auronomic Nervous System. 69. 56-63 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chen QH, Morita H er al.: "Sinoaortic denervation enhances sodium retention and mild hypertension in Dahl salt-sensitive rats"Journal of Auronomic Nervous System. 71. 175-182 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sei H, Morita H er al.: "Sino-aortic denervation augments the increase in blood pressure seen during paradoxical sleep in the rat"Journal of Sleep Research. 8. 45-50 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita H, et al.: "Functional evidence for involvement of bumetanide-sensitive Na^+ K^+ 2Cl^- cotransport in the hepatoportal Na^+ receptor of the Sprague-Dawley rat"Neurosci Lett. 264. 65-68 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hagiike M, Morita H, et al.: "The mechanism of the biphasic response of renal nerve activity during acute cardiac tam ponade in conscious rabbits"AmericanJournal of Physiology. 276. R1232-R1240 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Zhou M-S, Morita H er al.: "Effects of environment on tissue norepinephrine concentration in chum salmon"Journal if Experimental Zoology. 284. 107-111 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita H er al.: "Afferent mechanism of renal sympathetic nerve activity shutdown induced by short period of microgravity"Suppl 13. 182-183 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Lee K, Morita H er al.: "Pharmacological characterization of receptor-mediated Ca^<2+> entry in endothelin-induced catecholamine release from cultured bovine adrenal chromaffin cells"360. 616-622 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森田啓之: "受容器の宝庫肝臓:門脈-肝臓領域Na受容機構による予測制御的Na恒常維持"膜(Membrane). 24. 64-71 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita H er al.: "Hepatoportal bumetanide-sensitive K^+-sensor mechanism controls urinary K^+ excretion"AmericanJournal of Physiology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森田啓之: "肝-腎反射による体液恒常性維持"自律神経. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita H, Yamashita Y, Nishida Y, Tokuda M, Hatase O, Hosomi H: "Fos induction in rat brain neurons following stimulation of the hepatoportal Na-sensitive mechanism."American Journal of Physiology. 272. R913-R923 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsunooka K, Morita H: "Effect of a chronic high-salt diet on whole-body and organ sodium contents of Dahl rats."Journal of Hypertension. 15. 851-856 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishida Y, Sugimoto I, Morita H, Murakami H, Hosomi H, Bishop VS: "Suppression of renal sympathetic nerve activity during portal vein infusion of hypertonic saline."American Journal of Physiology. 274. R97-R103 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murakami H, Liu J-L, Yoneyama H, Nishida Y, Okada K, Kosaka H, Morita H, Zucker IH: "Blockade of neural nitric oxide synthase alters the baroreflex control of heart rate in the rabbit."American Journal of Physiology. 274. R181-R186 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada K, Nishida Y, Murakami H, Sugimoto I, Kosaka H, Morita H, Yamashita C, Okada M: "Role of endogenous endothelin in the development of graft arteriosclerosis in rat cardiac allografts: antiproliferative effects of bosentan, a nonselective endothelin receptor antagonist."Circulation. 97. 2346-2351 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita H, Tsunooka K, Hagiike M, Yamaguchi O, Lee K: "Role of the liver in long-term control of drinking behavior, Na Balance and arterial pressure in Dahl rats."American Journal of Physiology. 274. R1111-R1118 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugimoto I, Okada K, Murakami H, Nishida Y, Kosaka H, Morita H, Okada M: "The gain of the hepatorenal reflex in anesthetized dogs."Journal of the Autonomic Nervous System. 68. 164-170 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chen QH, Nishida Y, Zhou MS, Murakami H, Okada K, Morita H, Hosomi H, Kosaka H: "Sinoaortic denervation enhances sodium retention and mild hypertension in Dahl rats."Journal of the Autonomic Nervous System. 69. 56-63 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chen QH, Nishida Y, Zhou MS, Murakami H, Morita H, Hosomi H, Kosaka H: "Organ and development related difference in tissue norepinephrine concentrations in Dahl rats."Journal of the Autonomic Nervous System. 71. 175-182 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sei H, Morita Y, Tsunooka K, Morita H: "Sino-aortic denervation augments the increase in blood pressure seen during paradoxical sleep in the rat."Journal of Sleep Research. 8. 45-50 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita H, Fujiki N, Hagiike M, Yamaguchi O, Lee K: "Functional evidence for involvement of bumetanide-sensitive NaィイD1+ィエD1KィイD1+ィエD12ClィイD1-ィエD1 cotransport in the hepatoportal NaィイD1+ィエD1 receptor of the Sprague-Dawley rat."Neuroscience Letters. 264. 65-68 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hagiike M, Maeta H, Murakami H, Okada K, Morita H: "The mechanism of the biphasic response of renal nerve activity during acute cardiac tamponade in conscious rabbits."American Journal of Physiology. 276. R1232-R1240 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zhou M-S, Nishida Y, Chen Q-H, Nagamachi K, Morita H, Hosomi H, Kosaka H, Komiyama E, Ooyama Y: "Effects of environment on tissue norepinephrine concentration in chum salmon (oncorhynchus keta)"Journal of Experimental Zoology. 284. 107-111 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita H, Fujiki N, Hagiike M, Tanaka K, Tsuchiya Y, Miyahara T: "Afferent mechanism of renal sympathetic nerve activity shutdown induced by short period of microgravity."Biological Science in Space. [Suppl] 13. 182-183 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Lee K, Morita H, Iwamura Y, Zhang X-F, Okamoto Y, Nakagawa T, Hasegawa H, Furutani H, Miwa S, Masaki T: "Pharmacological characterization of receptor-mediated CaィイD12+ィエD1 entry in endothelin-1-induced catecholamine release from cultured bovine adrenal chromaffin cells."Naunyn-Schmiedeberg's Archive Pharmachology. 360. 616-622 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita H, Fujiki N, Miyahara T, Lee K, Tanaka K: "Hepatoportal bumetanide-sensitive KィイD1+ィエD1-sensor mechanism controls urinary KィイD1+ィエD1 excretion."American Journal of Physiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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