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1999 Fiscal Year Final Research Report Summary

Role of unsaturated fatty acids in brown adipose tissue function - with special reference to docosahexaenoic acid.

Research Project

Project/Area Number 09470014
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionASAHIKAWA MEDICAL COLLEGE

Principal Investigator

KUROSHIMA Akihiro  Asahikawa Medical College School of Medicine, Professor, 医学部, 教授 (90002774)

Co-Investigator(Kenkyū-buntansha) OHINATA. Hiroshi  Asahikawa Medical College, School of Medicine, Lecture, 医学部, 助手 (20233257)
Project Period (FY) 1997 – 1999
Keywordsbrown adipose tissue / docosahexaenoic acid3 / arachidonic acid / heat acclimation / fasting / thyroid hormones / nitric oxide / cold acclimation
Research Abstract

In an attempt to elucidate a role of membrane phospholipid n-3 polyunsaturated fatty acid (DHA) , the changes in DHA of rat brown adipose tissue (BAT) were studied under various conditions. (1) DHA and arachidonic acid (AA) were higher during neonatal period with higher BAT thermogenesis than in the adults. (2) DHA-supplemented diet increased BAT-DHA but decreased AA, resulting in the unchanged or decreased BAT in vitro thermogenesis. (3) DHA-deficient diet decreased BAT-DHA but not AA without BAT in vitro thermogenesis. (4) DHA plus AA-supplemented diet increased both fatty acids in BAT but did not change BAT in vitro thermogenesis. However, uncoupling protein 1 mRNA expression increased. (5) Chronic administration of nitric oxide synthase L-NAME did not change BAT-DHA, but decreased BAT in vitro thermogenesis due to decreased cellularity. (6) Heat acclimation or fasting decreased BAT-DHA and in vitro thermogenesis with correlation between these both parameters. (7) Methimazole-induced hypothyroidism decrease both DHA and AA, causing the decrease in BAT in vitro thermogenesis. Triiodothyronine-induced hyperthyroidism increased BAT in vitro thermogenesis due to hyperplasia without the changes of DHA. (8) Low rearing temperature during the neonatal to young period effected the long-lasting improved BAT in vitro thermogenesis as well as systemic nonshivering thermogenesis in later life. These findings suggest that DHA subserves as one of controlling factors of BAT thermogenic function.

  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Saha S.K.: "Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue"Jpn.J.Physiol. 47(5). 477-480 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroshima A.: "Adaptive changes in fatty acids profiles of thermogenic tissue brown fat"Fifth World Congress International Society for Adaptive Medicine(ISAM). 134 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha S.K.: "一酸化窒素(NO)と褐色脂肪組織(BAT)のDNA量、熱産生反応、脂肪酸組織"適応医学. 1(1). 32 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大日向浩: "ラット褐色脂肪組織脂肪酸組成の適応変化-特にドコサヘキサエン酸について-"適応医学. 1(1). 32 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohinata H.: "Effect of dietary docosahexaenoic acid on in vitro themogenesis and fatty acid compositions of brown adipose tissue"Jpn.J.Physiol. 48(3). 189-196 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha S.K.: "Thermogenesis and fatty acid composition of brown adipose tissue in rats rendered hyperthyroid and hypothyroid-with special reference to docosahexaenoic acid"Jpn.J.Physiol. 48(5). 355-364 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大日向浩: "熱産生器官-褐色脂肪組織脂肪酸組成の適応変化"臨床体温. 16(1). 22-29 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohinata H.: "Effects of a diet deficient in docosahexanoic acid (DNA) on nonshivering thermogenesis"Jpn.J.Physiol. 48(suppl.). s217 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大日向浩: "ラット非ふるえ熱産生におけるドコサヘキサエン酸の食餌性欠乏の影響"適応医学. 2(1). 63 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大日向浩: "ラット非ふるえ熱産生におけるドコサヘキサエン酸の食餌性欠乏の影響"臨床環境医学. 7(2). 63 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha S.K.: "In vitro thermogenesis and phospholipid fatty acid composition of brown adipsetissue in tasted and refed rats"Jpn.J.Physiol. 49(4). 345-352 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha S.K.: "Adaptive modification of membrane phospholipid fatty acid composition and metabolic suppression of brown adipose tissue in heat-acclimated rats"Int.J.Biometeorol. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroshima A.: "Some facets of brown adipose tissue pphysiology"The 76th Annual Meeting of Physiological Society of Japan Satellite Symposium on Advances in Environmental Physioligy. p23 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大日向浩: "絶食・再摂食時の褐色脂肪組織熱産生と膜リン脂質脂肪酸組織の変化"第76回日本生理学大会予稿集. p162 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha S.K.: "暑熱馴化ラット褐色脂肪組織(BAT)の熱産生及びリン脂質脂肪酸組成-特にドコサヘキサエン酸(DHA)の変化について"第76回日本生理学大会予稿集. p162 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha S.K.: "絶食・再摂食時の褐色脂肪組織熱産生と膜リン脂質脂肪酸組織の変化"Programme/AbstractsXI International Symposium Pharmacology of Thermoregulation. Board 17 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大日向浩: "ラット褐色脂肪組織熱産生能に対する生後環境温度の効果"日本生気象学会雑誌. 36(3). s50 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroshima A.(分担): "Adaptation Biology and Medicine Vol.1"Narosa Publising House. 446 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroshima A.: "Thermotherapy : Principles and Practice-Applications in Neoplasia, Inflammation, and Pain-"Springer-Verlag Tokyo, Icn. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saha, S. K.: "Effecta of nitric oxide synthase inhibition on phosphol ipid fatty acid composition of brown adipose tissue"Jpn. J. Physiol. 47(5). 477-480 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroshima, A.: "Effect of rearing temperature on thermogenic capaci ty of rat brown adipose tissue."Fifth World Congress International Society for Adaptive Medicine (ISAM). 134 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saha, S. K.: "Relation of nitric oxide (NO) to DNA, thermogenic response, fatty acids composition of brown adipose tissue (BAT)."J. Adaptation Med.. 1(1). 32 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Adaptive changes of fatty acids composition of rat brown adipose tissue-with special reference to docosahexaenoic acid."J. Adaptation Med.. 1(1). 32 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Effect of dietary docosahexaenoic acid on in vitro thermogenesis and fatty acid compositins brown adipose tissue."Jpn. J. Physiol.. 48(3). 189-196 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saha, S. K.: "Thermogenesis and fatty acid compositions of brown adipose tissue in rats rendered hyperthyroid of brown adipose tissue."Jpan. J. Physiol.. 48(5). 355-364 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Adaptive changes of fatty acids profiles in thermogenic organ brown adipose tissue."Thermometry and thermomdicine. 16(1). 22-29 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Effects of a diet deficient in docosahexaenoic acid (DHA) on nonshivering thermogenesis."Jpn. J. Physiol.. 48(suppl.). 217 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Effect of dificiency of docosahexaenoic acid on nonshivering thermogenesis in rats."J. Adap. Med.. 2(1). 63 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Effect of docosahexaenoic aci id deficiency on nonshivering thermogenesis in rats."Jpn. J. Clin. Ecol.. 7(2). 120 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saha, S. K.: "In vitro thermogenesis and phospholipid fatty acid composition of brown adipsetissue in tasted and refed rats."Jpn. J. Physiol. 49(4). 345-352 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saha, S. K.: "Adaptire modification of membrane phospholipid fatty acid compositlon and metabolic suppression of brown adipose tissue in heat accliruated rats."Int. J. Biometeorol. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroshima, A.: "Some facets of brown adipose tissue physiology."The76th Annual Meeting of Physiological Society of Japan Satellite Symposium on Advances in Environmental Physioligy. 23 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Changes in in vitro thermogenesis and phospholipid fatty acids of brown adipose tissue from fasted and refed rats."Abstracts of 76th Meeting of Physiological Society of Japan. 162 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saha, S. K.: "In vitro thermogenesis and phospholipid fatty aid composition of brown adipose tissue from heat-acclimated rats."Abstracts of 76th Meeting of Physiological Society of Japan. 162 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saha, S. K.: "Influence of heat acclimation on rat brown adipose tissue thermogenesis and phospholipid fatty acid composition."Programme / Abstracts XI International symposium Pharmacology of thermoregulation. Board 17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohinata, H.: "Effect of rearing temperature on thermogenic capacity of rat brown adipose tissue."Jpn. J. Biometeorol.. 36(3). S50 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroshima, A.: "Adaptation Biology and Medicine Vol. 1"Narosa Publising House. 446 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroshima, A.: "Brown adipose tissue and nonshivering thermogenesis in stressful states."Thermotherapy : Principles and Practice - Applications in Neoplasia, Inflammation, and Pain - ; Springer-Verlag Tokyo, Inc.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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