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1999 Fiscal Year Final Research Report Summary

Analysis of the molecular mechanisms for early host defense against bacterial infection

Research Project

Project/Area Number 09470076
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionNagoya University

Principal Investigator

YOSHIKAI Yasunobu  Nagoya University, School of Medicine, Professor, 医学部, 教授 (90158402)

Co-Investigator(Kenkyū-buntansha) NISHIMURA Hitoshi  School of Medicine, Research Associate, 医学部, 助手 (00283440)
Project Period (FY) 1997 – 1999
KeywordsBacterial infection / αβT cells / γδT cells / NK cells / NK T cells / IL-15 / Immunoregulation / Host Defense
Research Abstract

The host defense mechanisms are largely divided into three phases. Most of microorganisms are detected and destroyed within hours by innate immunity which preexists and is not antigen-specific. Innate immunity is mainly mediated by eptithelial cells and phagocytes such as macrophages and neutrophils. Innate immunity is followed by some hours later by early induced responses which can be activated by infection but do not generate lasting protective immunity. NK cells, γδT cells, NKαβT cells and memory phenotype of CD8ィイD1+ィエD1T cells are responsible for early induced responses. Late adaptive response is mediated by antigen-specific lymphocytes, which require several days for clonal expansion and differentiation of naive lymphocytes into effector cells. We examined the roles of early induced responses mediated by NK cells, γδT cells and NK αβT cells in bacterial infection using gene-knock out mice. Our findings are as follows :
(1) The bacterial growth in TCRβィイD1-/-ィエD1 mice had kinetics … More similar to that seen control mice (TCRβィイD1+/+ィエD1) after infection with avirulent Salmonella chorelaesuis 31N-1. The number of NK cells in the peritoneal cavity equally increased on day 3 after infection and thereafter decreased in both TCRβィイD1-/-ィエD1 mice and TCRβィイD1+/+ィエD1 mice, whereas the number of γδT cells were remarkably increased in the peritoneal cavity of TCRβィイD1-/-ィエD1 mice on day 6 after infection in place of αβT cells. The NK cells produced IFN-γ, whereas the γδT cells produced both IFN-γand IL-13 but no IL-4 in response to immobilized anti-TCR mAb. Anti-NK1.1mAb inhibited the reduction of bacteria after Salmonella infection, whereas anti-TCRγδmAb treatment did not. On the other hand, neutralization of endogenous IL-13 with anti-IL13mAb enhanced the bacterial clearance in TCRβィイD1-/-ィエD1 mice after Salmonella infection. These results indicate that NK1.1ィイD1+ィエD1 cells can serve to protect against avirulent Salmonella infection in the absence of αβT cells, whereas γδT cells may play at least dichotomus roles in Salmonella infection through IFN-γand IL-13 production.
(2) We next examined serum alanine aminotransferase (ALT), histopathology, and bacterial numbers in liver after infection with Salmonella choleraesuis strain 31N-1 in mice genetically lacking NK1.1ィイD1+ィエD1T cells. In control (ィイD1+/+ィエD1) mice, serum ALT reached a peak level by day 7 after an intraperitoneal inoculation of Salmonella choleraesuis 31N-1, whereas serum ALT levels were significantly decreased in b2mィイD1-/-ィエD1 and Ja281ィイD1-/-ィエD1 mice, which lacked in NK1.1ィイD1+ィエD1T cells that bearing TCR Val4-Jα281. αβT cells bearing NK1.1 may be main effector cells for liver injury after Salmonella infection. Less

  • Research Products

    (70 results)

All Other

All Publications (70 results)

  • [Publications] Yoshikai, Y.: "Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with acquired immunodeficiency syndrome"J. Virol.. 71. 746-749 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Enomoto, A.: "Predominant appearance of NK1.1+T cells producing IL-4 in the peritoneal cavity of mice with beige mutation during Salmonella infection"J. Immunol.. 158. 2268-2277 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura, H.: "Hsp 70 protects macrophages infected with Salmonella choleraesuis against TNF α-induced cell death"Cell Stress & Chaperones. 2. 50-59 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fuse, Y.: "CD95(Fas) may control the expansion of activated T cells after elimination of bacteria during the course of murine listeriosis"Infect. Immun.. 65. 1883-1891 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakai, T.: "Fas-mediated cytotoxicity by host intestinal intraepithelial lymphocytes is involved in the enteropathy during acute graft-vs.-host disease"Gastroenterology. 113. 168-174 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Upragarin, N.: "T cells bearing Vβ8 are preferentially infected with exogenous mouse mammary tumor virus"J. Immunol.. 159. 2189-2195 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kakumu, S.: "Serum levels of IL-10, IL-15, and soluble tumor necrosis factor-a receptors in type C chronic liver disease"Clin. Exp. Immunol.. 109. 458-463 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inagaki-Ohara, K.: "Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδT cell receptor in mice"Eur. J. Immunol.. 27. 2885-2891 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toki, Y.: "Protective efects of granulocyte colony-stimulating factor on encotoxin shock in mice with retrovirus-induced immunodeficiency syndrome"Cytokine. 9. 781-786 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inagaki-Ohara, K.: "Involvement of fas antigen/fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine"Lab. Invest.. 77. 421-429 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ito, K.: "Murine model IgE production with a predominant Th2-response by feeding protein antigen without adjuvants"Eur. J. Immunol.. 27. 3427-3437 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi, N.: "A sustained increase of cytosolic Ca2+ may be responsible for a apoptosis in γδT cells triggered by co-stimulation via TCR/CD3 and LFA-1"Cell Calcium.. 22. 421-430 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura, H.: "Translation efficiency is up-regulated by alternative exon in murine IL-15 mRNA"J. Immunol.. 160. 936-942 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura, Y.: "The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis"Int. Immunol.. 10. 117-130 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakai, T.: "Interleukin 15 Activity in the rectal mucosa of inflammatory bowel disease"Gastroenterology. 114. 1237-1243 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takano, M.: "Dibutyryl cyclic adnosine monophosphate protects mice against tumor necrosis factor-a-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression"Cell Stress Chaperones.. 3. 109-117 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Washizu, J.: "The NF-kB binding site is essential for transcriptional activation of the IL-15 gene"Immunogenetics. 48. 1-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murosaki, S.: "Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice"J. Allergy Clin. Immunol.. 102. 57-64 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takano, M.: "A protective role of IL-15-dependent γδT cells in Excherichia coil infection in mice"Infect. Immun.. 66. 3270-3278 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takano, M.: "Prostaglandin E2 protects against liver injury after Escherichia coil infection but hampers the resolution of the infection in mice"J. Immunol.. 161. 3019-3025 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirose, K.: "Interleukin-15 might be responsible early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats"Infect. Immun.. 66. 5677-5683 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada, K.: "Characterization of CD4^+ CD8aa^+ and CD4^-CD8aa^+ intestinal intraepithelial lymphocytes in rats"Int. Immunol.. 11. 21-28 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura, H.: "MHC class II-dependent NK1.1^+ gd T cell are induced in mice by Salmonella infection"J. Immunol.. 162. 1573-1581 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura, K.: "Immunogene therapy for murine fibrosarcoma using IL-15 gene with high translation efficiency"Eur. J. Immunol.. 29. 1532-1542 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishigami, M.: "The roles of intrahepatic Va 14^+NK1.1^+T cells for liver injury induced by Salmonella infection"Hepatology. 29. 1799-1808 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitani, A.: "Interleukin-15 might be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in mice"Immunolgy. 97. 92-99 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naiki, Y.: "Regulatory role of peritoneal NK1.1^+αβT cells in IL-12 production during Salmonella infection"J. Immunol.. 163. 2057-2063 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirose, K.: "Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of Salmonella choleraesuis in mice"J. Leukocyte Biol.. 66. 382-390 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mayumi, T: "IL-15 is elevated in the patients of postoperative enterocllitis"Cytokine. 11. 888-893 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka, S.: "Activation of T cells recognizing an epitope of heat shock protein(HSP) 70 can protect against rat adjuvant arthritis"J. Immunol.. 163. 5560-5565 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mokuno, Y: "Prostaglandin E_1 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T Cells in mice"Hepatology. 30. 1464-1472 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuguchi, T.: "Gene expressions of lipopolysaccharide receptors, Toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes"Blood. 95. 1378-1385 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura, H.: "Differencial roles of IL-15 mRNA isoforms generated by alternative splicing in immune responses in vivo"J. Exp. Med.. 191. 157-170 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura, K.: "Synergistic effect of IL-15 and IL-12 on anti-tumor activity in a murine malignant pleurisy model"Cancer. Immuno. Immunother.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mokuno, Y.: "γδT cells bearing invariant Vγ6/Vδ1 may respond to lipid A via Toll-like receptor 2"J. Immunol.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikai,Y., Kidokoro,H., Kimura,K., Makino,M. and Hiromatsu,K.: "Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with acquired immunodeficiency syndrome"J. Virol. 71. 746-749 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Enomoto,A., Nishimura,H. and Yoshikai,Y.: "Predominant appearance of NK1.1ィイD1+ィエD1 T cells producing IL-4 in the peritoneal cavity of mice with beige mutation during Salmonella infection"J. Immunol. 158. 2268-2277 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura,H., Emoto,M., Kimura,K. and Yoshikai,Y.: "Hsp 70 protects macrophages infected with Salmonella choleraesuis against TNF a-induced cell death"Cell Stress & Chaperones. 2. 50-59 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fuse,Y., Nishimura,H., Maeda,K.. and Yoshikai,Y.: "CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria during the course murine listeriosis"Infect. Immun.. 65. 1883-1891 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai,T., Kimura,Y., Inagaki-Ohara,K., Kusugami,K., Lynch, David,H. and Yoshikai,Y.: "Fas-mediated cytotoxicity by host intestinal intraepithelial lymphocytes is involved in the enteropathy during acute graft-vs.-host disease"Gastroenterology. 113. 168-174 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Upragarin,N., Nishimura,H., Wajjwalku,W., Ando,Y., Nagafuchi,S., Watanabe,T. and Yoshikai,Y.: "T cells bearing Vb8 are preferentially infected with exogenous mouse mammary tumor virus"J. Immunol.. 159. 2189-2195 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kakumu,S., Okumura,A., Ishikawa,T., Iwata,K., Yano,M., Enomoto,H., Nishimura,H., Yoshioka,K. and Yoshikai,Y.: "Serum levels of IL-10, IL-15, and soluble tumor necrosis factor- a receptors in type C chronic liver disease"Clin. Exp. Immunol.. 109. 458-463 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inagaki-Ohara,K., Nishimura,H., Mitani,A. and Yoshikai,Y.: "Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice"Eur. J. Immunol.. 27. 2885-2891 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toki,Y., Hiromatsu,K., Aoki,Y., Makino,M. and Yoshikai,Y.: "Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome"Cytokine. 9. 781-786 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inagaki-Ohara,K., Nishimura,H., Inagaki, H., Sakai,T., Takano,M., Lynch,D.H. and Yoshikai,Y.: "Involvement of fas antigen/fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine"Lab. Invest.. 77. 421-429 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ito,K., Inagaki-Ohara,K., Murosaki,S., Nishimura,H., Shimokata,T., Torii,S., Matsuda,T. and Yoshikai,Y.: "Murine model of IgE production with a predominant Th2-response by feeding protein antigen without adjuvants"Eur. J. Immunol. 27. 3427-3437 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, N., Hiromatsu,K., Matsumoto,Y. and Yoshikai,Y.: "A sustained increase of cytosolic Ca2ィイD1+ィエD1 may be responsible for apoptosis in gd T cells triggered by co-stimulation via TCR/CD3 and LFA-1"Cell Calcium. 22. 421-430 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura,H., Washizu,J., Nakamura,N., Enomoto,A. and Yoshikai,Y.: "Translation efficiency is up-regulated by alternative exon in murine IL-15 mRNA"J. Immunol. 160. 936-942 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura, Y., Yamada, K., Sakai,T., Mishima,K., Nishimura,H., Matsumoto,Y., Singh,M. and Yoshikai,Y.: "The regulatory role of heat shock protein 70-reactive CD4ィイD1+ィエD1 T cells during rat listeriosis"Int. Immunol. 10. 117-130 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai,T., Kusugami,K., Nishimura,H., Ando,T., Yamaguchi,T., Ohsuga,M., Ina,K., Enomoto,A., Kimura,Y. and Yoshikai,Y.: "Interleukin 15 Activity in the rectal mucosa of inflammatory bowel disease"Gastroenterology. 114. 1237-1243 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takano,M., Nishimura,H., Kimura,Y., Mokuno,Y., Washizu,J., Itohara,S., Nimura,Y. and Yoshikai,Y.: "A protective role of IL-15-dependent gd T cells in Escherichia coli infection in mice"Infect. Immun. 66. 3270-3278 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takano,M., Arai,T., Mokuno,Y., Nishimura,H., Nimura,Y. and Yoshikai,Y.: "Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-α-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression"Cell Stress Chaperones. 3. 107-117 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Washizu,J., Nishimura,H., Nakamura,N., Nimura,Y. and Yoshikai,Y.: "The NF-κB binding site is essential for transcriptional activation of the IL-15 gene"Immunogenetics. 48. 1-7 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murosaki,S., Yamamoto,Y., Ito,K., Inokuchi,T., Kusaka,H., Ikeda,H. and Yoshikai,Y.: "Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice"J. Allergy Clin. Immunol. 102. 57-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takano,M., Nishimura,H., Kimura,Y., Washizu,J., Nimura,Y. and Yoshikai,Y.: "Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice"J.Immunol. 161. 3019-3025 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirose,K., Suzuki,H., Nishimura,H., Mitani,A., Washizu,J., Matsuguchi,T. and Yoshikai,Y.: "Interleukin-15 might be responsible early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats"Infect. Immun. 66. 5677-5683 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada,K., Kimura,Y., Nishimura,H., Namii,Y., Murase,M. and Yoshikai,Y.: "Characterization of CD4ィイD1+ィエD1 CD8ααィイD1+ィエD1 and CD4ィイD1-ィエD1 CD8ααィイD1+ィエD1 intestinal intraepithelial lymphocytes in rats"Int. Immunol. 11. 21-28 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura,H., Washizu,J., Naiki,Y., Fukui,Y., Sasazuki,T. and Yoshikai,Y.: "MHC class II-dependent NK1.1ィイD1+ィエD1 γδT cells are induced in mice by Salmonella infection"J. Immunol. 162. 1573-1581 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura,K., Nishimura,H., Hirose,K., Matsuguchi,T., Nimura,Y. and Yoshikai,Y.: "Immunogene therapy for murine fibrosarcoma using IL-15 gene with high translation efficiency"Eur. J. Immunol. 29. 1532-1542 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishigami,M., Nishimura,H., Naiki,Y., Yoshioka,Y., Kawano,T., Tanaka,Y., Taniguchi,M., Kakumu,S. and Yoshikai,Y.: "The roles of intrahepatic Vα14ィイD1+ィエD1 NK1.1ィイD1+ィエD1 T cells for liver injury induced by Salmonella infection"Hepatology. 29. 1799-1808 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitani,A., Nishimura,H., Hirose,K., Washizu,J., Kimura,Y., Tanaka,S., Noguchi,T. and Yoshikai,Y.: "Interleukin-15 might be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in mice"Immunology. 97. 92-99 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naiki,Y., Nishimura,H., Kawano,T., Tanaka,Y., Itohara,S., Taniguchi,M., Yoshikai,Y.: "Regulatory role of peritoneal NK1.1ィイD1+ィエD1 αβT cells in IL-12 production during Salmonella infection"J. Immunol. 163. 2057-2063 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirose,K., Nishimura,H., Matsuguchi,T. and Yoshikai,Y.: "Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with avirulent strain of Salmonella choleraesuis in mice"J. Leukocyte Biol.. 66. 382-390 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mayumi,T., Takezawa,J., Nishimura,H., Enomoto,A., Ichiyama,S. and Yoshikai,Y.: "IL-15 is elevated in the patients of postoperative enterocllitis"Cytokine. 11. 888-893 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka,S., Kimura,Y., Mitani,A., Yamamoto,G., Nishimura,H., Spaller,R., Singh,M., Noguchi,T., Yoshikai,Y.: "Activation of T cells recognizing an epitope of heat shock protein (HSP) 70 can protect against rat adjuvant arthritis"J. Immunol. 163. 5560-5565 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mokuno,Y., Takano,M., Matsuguchi,T., Nishimura,H., Washizu,J., Naiki,Y., Kimura,Y. and Yoshikai,Y.: "Prostaglandin EィイD21ィエD2 protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice"Hepatology. 30. 1464-1472 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuguchi,T., Takagi, k., Musikacharoen,T. and Yoshikai,Y.,: "Gene expressions of lipopolysaccharide receptors, Toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes"Blood. 95. 1378-1385 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura,H., Yajima,T., Naiki,Y., Tsunobuchi,H., Umemura,M., Itano,K., Matsuguchi,T., Suzuki,M., Ohashi,P, M. and Yoshikai,Y.: "Differential roles of IL-15 mRNA isoforms generated by alternative splicing in immune responses in vivo"J. Exp. Med.. 191. 157-170 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura,K., Nishimura,H., Matsuzaki,T., Yokokura,T., Nimura,Y. and Yoshikai,Y.: "Synergistic effect of IL-15 and IL-12 on anti-tumor activity in a murine malignant pleurisy model"Cancer. Immunol. Immunother. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mokuno,Y., Matsuguchi,T., Takano,M., Nishimura,H., Washizu,J., Ogawa,T., Nimura,Y. and Yoshikai,Y.: "γδcells bearing invariant Vγ6/Vδ1 may respond to lipid A via Toll-like receptor 2"J. Immunol. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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