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1998 Fiscal Year Final Research Report Summary

Investigation into the molecular mechanism of fatigue sensation

Research Project

Project/Area Number 09470126
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionOsaka University

Principal Investigator

KURATSUNE Hirohiko  Osaka University Medical School, Assistant Professor, 医学部, 助手 (50195533)

Co-Investigator(Kenkyū-buntansha) MACHII Takashi  Osaka University Medical School, Associate Professor, 医学部, 助教授 (50124780)
MIZUKI Masao  Osaka University Medical School, Assistant Professor, 医学部, 助手 (80283761)
WATANABE Yasuyoshi  Osaka Bioscience Institute, Director, 第3部門, 部長(研究職) (40144399)
Project Period (FY) 1997 – 1998
KeywordsFatigue Sensation / Mechanism / Acylcarnitine / Neurometabolic Substances / Pasitron Emission Tomography / Glutamic Acid / Cytokine / TGF-beta
Research Abstract

Chronic fatigue syndrome (CFS) is an operational concept to clarify the unknown etiology of the syndrome characterized by chronic fatigue. Recently, we demonstrated that most CFS patients had serum acetylcarnitine (ACC) deficiency, and that serum ACC has a very important physiological role for the brain, that is, conveying an acetyl moiety into the brain. To clarify whether or not the abnormality of regional cerebral ACC metabolism (rCMRacetylcar) is associated with pathology of CFS, we studied both the regional cerebral blood flow (rCBF) and rCMRacetylcar in 8 CFS patients and 8 age-matched controls using 11 C-labeled ACC and positron emission tomography scans. A high ACC uptake was found in the cerebral oortex, and it was higher in the gray matter than in the white matter. From group-to-group comparisons, CFS group had a lot of brain regions where rCBF decreases, especially in anterior cingulate, left lateral cortices and some basal ganglia. On the contraiy, the regions in which showed lower rCMRacetylcar were restricted, and an apparent deficiency was found only in Brodmann's area 9 and 24, where is associated with autonomic, affective and motivational behaviors. The metabolic analysis suggested that an acetyl moiety taken into the cerebral cortex might be used for biosynthesis of an important neurometabolic substances, and the hypometabolism of ACC in Brodmann's area 9 and 24 might be a key feature of CFS, associating with the neuro-psychiatric symptoms.

  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Jacobson, G.B., et al.: "Synthesis of [^<11>C] Acetyl-CoA and [^<11>C] Acetyl-L-Carnitine labelled in multiple positions" Nucl Med BioL. 24. 471-478 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "High uptake of [2-1 1 C] Acetyl-L-carnitine into the brain : a pet study." Biochem Biophys Res Commun. 231. 488-493 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tedroff, J., et al.: "L-DOPA modulates striatal dopaminergic activity in vivo. Evidence from PET investigations in nonhuman primates." Synapse. 25. 56-61 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe, Y., et al.: "Tracing oxygen metabolism by use of positron emitter oxygen-15." Biochem Biophys Res Commun. 231. 131-134 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome." Int J Mol Med. 1. 143-146 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases." Int J Mol Med. 2. 51-56 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases." Int J Mol Med. 2. 51-56 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "The Exerts Speak Interiews : Chronic Fatigue Syndrome and Acylcarnitine." Clincal Pears News. 8・6. 88-89 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cao, C., et al.: "Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor." Mol.Brain Res. 56. 45-56 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumura, K., et al.: "Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever : Light and electron microscopic immunocytochemical studies." J.Neurosci.18. 6279-6289 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sihver, W., et al.: "(S) [^<11>C] Nicotine, (R, S) -1- [^<11>C] methyl-2- (3-pyridyl) azetidine, and (S) -3-methyl-5- (1- [^<11>C] methyl-2-pyrrolidinyl) -isoxazol as ligands for positron emission tomography : a comparative in vitro evaluation to characterize nicotinic receptors in the brain." J.Neurochem.71. 1750-1760 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cao, C., et al.: "Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of endothelial cyclooxygenase-2." J.Neurosci.19. 716-725 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "Carnitine Today Acylcarnitine and Chronic Fatigue Syndrome" Molecular Biology Intelligence Unit, Landes Bioscience, Austin, Texas, USA, 195-213 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuratsune, H., et al.: "Acylcarnitine Deficiency in Chronic Fatigue Syndrome." Clin Infect Dis. 18(Suppl 1). S62-67 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yalcin, S., Kutatsune, H., et al.: "Prevalence of Human Herpesvirus 6 Variants A and B in Patients with Chronic Fatigue Syndrome." Microbiol Immunol. 38(7). 587-90 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuratsune, H., et al.: "Abnormal cellular carnitine metabolism in chronic fatigue syndrome." EOS-J Immunol Immunopharmacol. 15(1-2). 40-44 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakaya T,Takahashi, H., et al.: "Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome." FEBS Lett. 378. 145-49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitani T., Kuratsune, H., et al.: "Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome." Microbiol Immunol. 40(6). 459-62 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguti, K., Kuratsune, H., et al.: "Acylcarnitine Metabolism during fasting and refeeding." Biochem Biophys Res Commun. 225. 740-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jacobson, G.B., Watanabe, Y., et al.: "Synthesis of [^<11>C] Acetyl-CoA and [^<11>C] Acetyl-L- Carnitine labelled in multiple positions." Nucl Med Biol. 24. 471-478 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuratsune, H., et al.: "Acylcarnitine and Chronic Fatigue Syndrome." In : Carnitine Today. DeSimone, C., Famularo, G.(Eds.) Molecular Biology Intelligence Unit, Landes Bioscience, Austin, Texas, USA. 195-213 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuratsune, H., et al.: "High uptake of [2-1 1C] Acetyl-L-carnitine into the brain : a pet study." Biochem Biophys Res Commun. 231. 48*493 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuratsune, H., et al.: "Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome." Int J Mol Med. 1. 143-146 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuratsune, H., et al.: "Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C,but not seen in other diseases." Int J Mol Med. 2. 51-56 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuratsune, H.: "The Exerts Speak Interviews : Chronic Fatigue Syndrome and Acylcarnitine." Clincal Pears News. 8(6). 88-89 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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