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1999 Fiscal Year Final Research Report Summary

PREDICTION OF RADIOTHERAPEUTIC EFFECTS ON TUMOR USING POSITRON EMISSION TOMOGRAPHY

Research Project

Project/Area Number 09470195
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KUBOTA Kazuo  INSTITUTE OF DEVELOPMENT, AGING AND CANCER, DEPT. NUCLEAR MEDICINE AND RADIOLOGY, Tohoku University, ASSOCIATE PROFESSOR, 加齢医学研究所, 助教授 (40161674)

Co-Investigator(Kenkyū-buntansha) IWATA Ren  DEPT. QUANTUM ENERGY ENGINEERING, GRADUATE SCHOOL OF ENGINEERING, Tohoku University, ASSOCIATE PROFESSOR, 大学院・工学研究科・量子エネルギー専攻, 助教授 (60143038)
Project Period (FY) 1997 – 1999
Keywordsdeoxyglucose / methionine / ィイD118ィエD1F-fluoromisonidazole / autoradiography / tumor / hypoxia / positron emission tomography
Research Abstract

To evaluate tumor imaging potential of 18F-fluoromisonidazole (FMISO), we studied FMISO uptake in an experimental tumor model and examined the correlation between intra-tumoral distributions of FMISO, 14C-2-deoxyglucose (2DG) and 14C-methionine (Met). Methods: We studied the issue distribution and double tracer autoradiography using control rats with AH109A tumor and rats with the same tumor under local hypoxia. Results: Tumor uptake of FMISO was constant between 30 min to 2 hr after injection, and the tumor to muscle ratio was 2, from 2 to 4 hr. A tumor study with FMISO was scheduled at 2 hr. Double tracer autoradiography of the tumor demonstrated that in the areas of high FMISO uptake, there was low uptake of Met, while low FMISO uptake areas showed high Met uptake. FMISO showed high grain density in the rim of the tumor surrounding the necrotic area. 2DG showed more uniform distribution over the entire section of viable cells. The mean uptake of FMISO by hypoxic, radioresistant tumors was significantly higher than the control tumors (p<0.05), while both 2DG and Met uptake by the control tumor were higher than hypoxic tumor. When individual tumors were examined, the uptake of FMISO was inversely correlated with that of Met (r=-0.507, p<0.02), while 2DG showed almost uniform uptake with no significant correlation to FMISO. Conclusions: Hypoxic and radioresistant tumour can be identified by increased FMISO uptake in our model consistent with works reported by others. We found a large overlap in the distribution of FMISO and 2DG within the tumor, but only a small overlap in the distribution of FMISO and Met. A combination of FMISO and other tracers in PET or SPECT study would possibly be more helpful than single tracer study in predicting the response of tumor tissues to radiotherapy.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Reinhardt M.,Kubota K.et al.: "Assessment of cancer recurrence in residual tumors after radiotherapy"Journal of Nuclear Medicine. 38. 280-287 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imran MB.,Kubota K.et al.: "Lesion to background ratio in non-attenuation corrected whole-body FDG PET images"Journal of Nuclear Medicine. 39. 1219-1223 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imran MB.,Kubota K.et al.: "Sclerosing mediastinitis : findings on FDG-PET"Clinical Nuclear Medicine. 24. 305-308 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tashiro M.,Kubota K.et al.: "Hypometabolism in the limbic system of cancer patients"Psycho-oncology. 8. 283-286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kubota K.,Tada M.et al.: "Comparison of distribution of ^<18>F-MISO,2DG and Met in tumor"European Journal of Nuclear Medicine. 26. 750-757 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohira H.,Kubota K.et al.: "Comparison of intra-tumor distribution of ^<99m>Tc-MIBI and 2DG"Journal of Nuclear Medicine. 41(in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 福田寛、窪田和雄、阿部由直: "PETによる放射線治療感受性の予測 In"癌の放射線治療""金芳堂. (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 窪田和雄: "PETによる腫瘍診断 In_最新臨床核医学第3版"金原出版. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Reinhardt M, Kubota K, Yamada S, Iwata R, Yaegashi H: "Assessment of cancer recurrence in residual tumors after fractionated radiotherapy : a comparison of fluorodeoxyglucose"L-methionine and thymidine. J. Nucl. Med.. 38. 280-287 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Abe Y, Takahashi J, Fukuda H, Ono S, Yoshioka S, Akaizawa T, Kubota K, Yamada K, Takahashi T, Ohkuda K, Asoh N, Yonechi M, Maehira N, Mariya S, Aoki M: "A phase II study of cisplatin, oral administration of etoposide, OK-432 and radiation therapy for inoperable stage III non-small cell lung cancer"Int. J. Clin. Oncol.. 3. 365-369 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imran M, Kubota K, Yamada S, Fukuda H, Yamada K, Fujiwara T, Itoh M: "Lesion-to-background ratio in nonattenuation-corrected whole-body FDG PET images"J. Nucl. Med.. 39. 1219-1223 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imran M, Kubota K, Yoshioka S, Yamada S, Sato T, Fukuda H, Yoshioka T, Kanamaru R, Fujiwara T, Itoh M: "Sclerosing mediastinitis : Findings on Fluorine-18 Fluorodeoxyglucose positron emission tomography"Clin. Nucl. Med.. 24(5). 305-308 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kubota K, Tada M, Yamada S, Hori K, Saito S, Iwata R, Sato K, Fukuda H, Ido T: "Comparison of 18F-fluoromisonidazole, deoxyglucose and methionine in tumor tissue distribution"Eur. J. Nucl. Med.. 26. 750-757 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tashiro M, Fujimoto T, Itoh M, Kubota K, Fujiwara T, Miyake M, Watanuki S, Horikawa E, Sasaki H, Ido T: "18F-FDG PET Imaging of muscle activity in runners"J. Nucl. Med.. 40. 70-76 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tashiro M, Kubota K, Itoh M, Nakagawa Y, Yoshida M, Kamada M, Bereczki D, Sasaki H: "Hypometabolism in the limbic system of cancer patients observed by positron emission tomography"Psyco-Oncology. 8. 283-386 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohira H, Kubota K, Ohuchi N, Harada Y, Fukuda H, Satomi S: "Comparison of intra-tumoral distribution of technetium^99m-sestamibi and deoxyglucose in mouse breast cancer models"J. Nucl. Med.. (in press). 27 (2000)

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      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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