1998 Fiscal Year Final Research Report Summary
Basic studies for Alzheimer's disease and advanced glycation and products
| Project/Area Number |
09470204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MAKITA Zenji Medical Hospital, Hokkaido University, Lecturer, 医学部・附属病院, 講師 (50261285)
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| Co-Investigator(Kenkyū-buntansha) |
FUKATSU Ryou Sapporo Medical School, Associate Professor, 医学部, 助教授 (10113614)
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| Project Period (FY) |
1997 – 1998
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| Keywords | ALZHEIMER'S DISEASE / DIABETES MELLITUS / PATHOLOGY |
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| Research Abstract |
Advanced glycation end products (AGEs) have been implicated in the chronic complications of diabetes mellitus and have been reported to play an important role in the pathogenesis of Alzheimer's diabetes. In this study, we examined the immunohistochemical localization of AGEs, amyloid beta protein (Abeta), apolipoprotein E(Apo E), and tau protein in senile plaques, neurofibrillary tangles (NFTs), and cerebral amyloid angiopathy (CAA) in Alzheimer's disease and other neurodegenerative diseases (progressive supranuclear palsy, Pick's disease, and Guamanian amyotrophic Lateral sclerosis/Parkinsonisrn-dementia complex) .In most senile plaques (including diffuse plaques)and CAA from Alzheimer's brains, AGE and ApoE were observed together.However , approximately 5% of plaques were AGE positive but A beta negative, and the vessels without CAA often showed AGE immunoreactivity. In Alzheimer's disease, AGES were mainly present in intracellular NFTs, whereas ApoE was mainly present in extracellular NFTs. Pick's bodies in Pick's disease and granulovacuolar degeneration in various neurodedegenerative disease, senile plaques and NFTs showed similar findings to those in Alzheimer's disease. These results suggest that AGE may contribute to eventual neuronal dysfunction and death as an important factor in the progression of various neurodegenerative diseases, including Alzheimer's disease.
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