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1998 Fiscal Year Final Research Report Summary

Study of pathogenesis and treatment in metastatic bone disease

Research Project

Project/Area Number 09470313
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

UCHIDA Atsumasa  Mie University, Faculty of Medicine, Professor, 医学部, 教授 (40176681)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Takashi  Mie University, Faculty of Medicine, Assistant, 医学部, 助手 (70230399)
Project Period (FY) 1997 – 1998
KeywordsBone metastasis / Animal model / Polyamine synthesis inhibition / hyperthermia
Research Abstract

1. Animal model for investigation of pathogenesis in metastatic bone disease
In order to establish an animal model for bone metastasis B-16 melanoma cells were injected into the heart after implantation of allogenic bone in the back of a C57BL/6 mouse. Metastasis were found at high frequent in the extra skeletal bones implanted subcutaneously after 4week inoculation of the tumor cells. The original model, being an unique and useful, was applied for the study of progress of bone metastasis and angiogenesis.
2. Treatment study of bone metastasis
Intraperitoneal administration of Polyamine synthesis inhibitor, Methylglyoxal-bis-cyclopentylamidinohydrazone (MGBCP), showed significant decrease of metastatic rate in the implanted bone, compared to control group. This pathogenesis may be inhibition of tumor cell growth and angiogenesis. No adverse effects were found in this experimental series.
3. Treatment by local hyperthermia to metastatic bone disease
Local hyperthermia by ferromagnetic field showed a significant inhibitory effect of growth of metastasis in the bone.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] H.Obata: "Smooth muscle cell phenotype-dependent transcriptional regulation of the integrin gene" J Bio Chem. 17. 26643-26651 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takegami: "New ferromagnetic bone cement for local hyperthermia" Bioceramic. 10. 535-538 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto.N: "Clinical relevance of the SYT-SSX fusion gene in synovial sarcoma" J Musculoskeletal Res. 1. 111-119 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Uchida: "Bone and soft tissue sarcomas : Summary of the third united states/Japan clinical trials summit J Cancer Res Clin Oncol" J Cancer Res Clin Oncol. 123. 674-677 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takegami: "New ferromagnetic bone cement for local hyperthermia" J Biomed Mater Res. 43. 210-214 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Matsui: "Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors" Cancer Letters. 124. 143-148 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yoshikawa: "Surgical treatment for skeletal metastases from soft tissue sarcomas : experience with 23 lesions in 20 patients" Sarcoma. 2. 107-114 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Yamashita: "Antitumor effect by sustained release of tumor necrosis factor using porous ceramic delivery system" Bioceramics. 11. 541-544 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Obata: "Smooth muscle cell phenotype-dependent transcriptional regulation of the integrin gene" J Bio Chem. 17. 26643-26651 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Takegami: "New ferromagnetic bone cement for local hyperthermia" Bioceramic. 10. 535-538 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hashimoto.N: "Clinical relevance of the SYT-SSX fusion gene in synovial sarcoma" J Musculoskeletal Res. 1. 111-119 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Uchida: "Bone and soft tissue sarcomas : Summary of the third united states/Japan clinical trials summit J Cancer Res Clin Oncol" J Cancer Res Clin Oncol. 123. 674-677 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Takegami: "New ferromagnetic bone cement for local hyperthermia" J Biomed Mater Res. 43. 210-214 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Matsui: "Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors" Cancer Letters. 124. 143-148 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yoshikawa: "Surgical treatment for skeletal metastases from soft tissue sarcomas : experience with 23 lesions in 20 patients" Sarcoma. 2. 107-114 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yamashita: "Antitumor effect by sustained release of tumor necrosis factor using porous ceramic delivery system" Bioceramics. 11. 541-544 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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