1998 Fiscal Year Final Research Report Summary
The study on mechanism for regulation of interaction between human decidua and villi.
| Project/Area Number |
09470364
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yokohama City University |
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Principal Investigator |
TAKAHASHI Tsuneo Yokohama City University, OB/GYN,Assistant Professor, 医学部, 講師 (60179497)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Mario Yokohama City Univ., OB/GYN,Lecturer, 医学部, 助手 (50254173)
SHIGETA Hiroyuki Yokohama City Univ., OB/GYN,Assistant Professor, 医学部, 講師 (20275051)
TAGA Michiyoshi Yokohama City Univ., OB/GYN,Associate Professor, 医学部, 助教授 (00107682)
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| Project Period (FY) |
1997 – 1998
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| Keywords | growth factor / lactoferrin / decidua / villi / placenta / KGF / hCG / BeWo cell |
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| Research Abstract |
To investigate the mechanism by which embryo-endometrial/decidual interaction, we analyzed the biological actions of local factors such as growth factor and lactoferrin in human endometrium/decidua and villi.
KGF, the gene of which enhanced in secretory phase endometrium and decidua, stimulated hCG secretion, but did not affect ^3H-thymidine incorporation in BeWo cells, human choriocarcinoma cell line. KGF receptor mRNA was detected in villi and BeWo cells, indicating that the action of KGF on hCG secretion was mediated through KGF receptor.
PDGF, which was also produced in decidual cells, had a strong cell proliferative effect on decidual cells.
The immunohistochemical analysis of localization of lactoferrin in the human placenta revealed that it was prominent in the tissues with chorioamnionitis, suggesting lactoferrin in these tissues exerts an antiinflammatory effect.
These results indicate that local factors such as growth factor and lactoferrin play an important role in the regulation of implantation, placentation, and maintenance of pregnancy by acting in an autocrine/paracrine fashion.
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[Publications] Ikeda, M., Taga, M., Sakakibara, H., Minaguchi, H., Ginsburg, E., Vonderhaar, B.K.: "Gene expression of gonadotropin-releasing hormone in early pregnant rat and steroid hormone exposed mouse uteri." J.Endocrinol. Invest. 19. 708-713 (1997)
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[Publications] Saji, M., Taga, M., Matsui, H., Suyama, K., Kurogi, K., Minaguchi, H.: "Gene expression and specific binding of platelet-derived growth factor and its effect on DNA synthesis in human decidual cells." Mol.Cell.Endocrinol. 132. 73-80 (1997)
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[Publications] Kida, H., Taga, M., Minaguchi, H., Hanazono, M., Ohashi, T., Sakakura, T., Kusakabe, M.: "The change in tenascin expression in mouse uterus during early pregnancy." J.Assist. Reprod. Gen.14. 44-50 (1997)
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