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1998 Fiscal Year Final Research Report Summary

Pathogenesis and new treatments of middle ear cholesteatomas

Research Project

Project/Area Number 09470373
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagasaki University

Principal Investigator

KOBAYASHI Toshimitsu  Nagasaki University, School of Medicine, Professor, 医学部, 教授 (80133958)

Co-Investigator(Kenkyū-buntansha) KANDA Yukihiko  Nagasaki University, School of Medicine Hospital, Assistant, 医学部附属病院, 助手 (20264244)
NAKAO Yoshiaki  Nagasaki University, School of Medicine Hospital, Lecturer, 医学部附属病院, 講師 (40188884)
SHIGENO Koichiro  Nagasaki University, School of Medicine, Assistant Professor, 医学部, 助教授 (10162588)
Project Period (FY) 1997 – 1998
Keywordscholesteatoma / epidemiology / patulous eustachian tube / labyrinthine fistula
Research Abstract

(1) Epidemiological research on the incidence of middle ear cholesteatoma was conducted based on the questionarres directed to the otolaryngologists in Nagasaki Prefecture. The study revealed that the incidence of middle ear cholesteatoma among Nagasaki Prefecture habitant can be estimated as 4.44 per every 100,000 population per year. This figure was similar to the one we previously obtained from the study conducted in Miyagi Prefecture in 1994 and 1995. This suggests that the incidence of middle ear cholesteatoma as estimated from the surgical cases in Japan is about 4 per 100,000 population per year.
(2) Familial onset of middle ear cholesteatoma and other related middle ear diseases was investigated. Among the 18 families (40 members) in which a patient with cholesteatoma was confirmed by surgery, 10 persons from 7 families were revealed to have middle ear pathology, such as atelectasis of the tympanic membrane, attic retractions, etc..
(3) Incidence of association of the patulous eu … More stachian tube in cholesteatoma was about 30-40% of all cholesteatoma cases. Bases on this background, a new surgical approach to the patulous eustachian tube was developed by us and performed in 22 cases (30 ears). The success rate of the surgery was calculated as 73% (11/15) for patulous eustachian tube uncomplicated with middle car diseases other than patulous tube and 93% (14/15) in ears complicated with middle ear diseases.
(4) Labyrinthine fistula is the most frequent complication of the middle ear cholesteatomas. The interruption of the semicircular canals was experimentally conducted on the guinea pig. Tue interruption of the 3 semicircular canals did not cause major decrease of the cochlear potentials, however, when suction was applied to the one open end of the semicircular canals, they decreased drastically. This decrease was enhanced when the other ends of the suction site was dry. In constrast, when the other ends were covered with saline solution, the decrease of the cochlear potentials was less prominent. This study implies that when manipulating the labyrinthine fistula one should avoid direct suction, and use irrigation of saline solution. Less

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 小林俊光,他: "鼻すすり,閉鎖不全耳管と耳疾患." 耳鼻展望. 40. 342-346 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林俊光,他: "耳科,頭蓋底外科における迷路操作について." 耳喉頭頚. 69. 749-757 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林俊光: "鼓室形成術-最近の進歩-" 日本医事新報. 3843. 20-24 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林俊光,田中藤信: "錐体部真珠腫" 耳鼻臨床. 90. 500-501 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高村博光,小林俊光,他: "鼓室形成術O型の術後聴力." Otol Jpn. 8. 536-539 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂井 真,小林俊光,他: "先天性真珠腫をめぐる諸問題." 耳鼻臨床. 91. 541-557 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi T, Yaginuma Y, Suetake M, et al: "Sniffing, insufficient closure of the eustachian tube in middle ear diseases." Otolaryngology-Head and Neck Surg (Tokyo). 69. 749-757 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi T, Tanaka F, Sato T: "Manipulation of the labyrinth in middle ear surgery and skull base surgery." Oto-Rhino-Laryngology, Tokyo. 40. 342-346 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi T: "Tympanoplasty, its new development." Nippon Iji Shinpo. 3843. 20-24 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi T, Tanaka F: "Petrous bone cholesteatoma" Pract Otologica (Kyoto). 90. 500-1 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takamura H, Suetake M, Oyama K, Kobayashi T: "Hearing resulrs after so called type 0 tympanoplasty" Otol Jpn. 8. 536-9 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai M, Kobayashi T, Suetake M, et al.: "Congenital cholesteatomas." Practica Otologica (Kyoto). 91. 541-547 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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