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1999 Fiscal Year Final Research Report Summary

Brain mechanisms of taste quality and hedonic processing

Research Project

Project/Area Number 09470401
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Takashi  Fac. of Human Sci., Osaka Univ., Professor, 人間科学部, 教授 (60028793)

Co-Investigator(Kenkyū-buntansha) YASOSHIMA Yasunobu  Fac. of Human Sci., Osaka Univ., Res. Associate, 人間科学部, 助手 (00273566)
SAKO Noritaka  Fac. of Human Sci., Osaka Univ., Res. Associate, 人間科学部, 助手 (90243154)
SIMURA Tsuyoshi  Fac. of Human Sci., Osaka Univ., Assistant Professor, 人間科学部, 講師 (80150332)
Project Period (FY) 1997 – 1999
KeywordsTaste / Quality / Hedonics / Brain / Behavior / Neuroscience
Research Abstract

1) To elucidate the involvement of brain areas in conditioned taste aversion (CTA), we studied the induction of immediate-early genes, c-fos and zif268 as markers of neuronal activation. In the CTA conditioning procedure, rats ingested the conditioned stimulus (CS, 0.5 M sucrose) and received an i. p. injection of 0.15 M LiCI (2% of body weight) as the unconditioned stimulus (US). We compared expressions of c-fos-like (c-FLI) and ZIF (ZIR) immunoreactivities in different rats. The number of c-FLI and ZIP positive cells in the supramammillary area (SuM) of those rats re-exposed to the CS was significantly larger than in those to other rats. In the behavioral study, lesions of the SuM before the single CS-US pairing caused no disruption of the acquisition of the aversion but accelerated its extinction. These results suggest that the SuM cell participate in acquisition mechanism of CTA formation.
2) Opioids are suggested to be involved in generation of palatability and facilitation of consumption of food and fluid. We measured the level of an endogenous opioid, β-endorphin, in the cerebrospinal fluid (CFS) and plasma after free drinking of water and taste solutions in Wistar rats. The results suggest that the release of β-endorphin is positively correlated with the palatability of taste stimuli, and that CSF β-endorphin also reflects the reinforcement of fluid intake in thirsty animals.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] N. Sakai and T, Yamamoto: "Conditioned taste aversion and c-fos expression〜"Neuro Report. 8・9. 2215-2220 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T, Yamamoto, N. Sako, et al.: "Gustatory and visceral inputs to the amygdala〜"Neuroscience Letters. 226・2. 127-130 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Shimura, H. Tanaka and T, Yamamoto: "Salient responsiveness of parabrachial neurons〜"Neuroscience. 81・1. 239-247 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Yasoshima and T, Yamamoto: "Short-term and long-term excitability changes〜"Neuroscience. 284・1. 1-5 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Sako and T, Yamamoto: "Electrophysiological and behavioral studies〜"American Journal of Physiology. 276・2. R388-R396 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Sakai and T, Yamamoto: "Possible routes of visceral information in the 〜"Neuroscience Research. 35・1. 53-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Harada, T. Yamamoto, K. Yamaguchi and Y. Kasahara: "Different characteristics of gustatory responses between the greater superficial petrosal and chorda tympani nerves in the rat."Chemical Senses. 22(2). 133-140 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Yasoshima and T. Yamamoto: "Rat gustatory memory requires protein kinase C activity in the amygdala and cortical gustatory area."NeuroReport. 8(6). 1363-1367 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Sakai and T. Yamamoto: "Conditioned taste aversion and c-fos expression in the rat brainstem after administration of various USs."NeuroReport. 8(9). 2215-2220 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Yamamoto, N. Sako, N. Sakai and A. Iwafune: "Gustatory and visceral inputs to the amygdala of the rat : conditioned taste aversion and induction of c-fos-like immunoreactivity"Neuroscience Letters. 226(2). 127-130 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Shimura, Z. Karadi and T. Yamamoto: "Facilitation of glutamate release in the ventromedial division of the globus pallidus during palatable taste stimulation in freely moving rats : real-time measurement."Neuroscience Research. 28(3). 281-284 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Shimura, H. Tanaka and T. Yamamoto: "Salient responsiveness of parabrachial neurons to the conditioned stimulus after the acquisition of taste aversion learning in rats."Neuroscience. 81(1). 239-247 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Shimura, M. Komori and T. Yamamoto: "Acute sodium deficiency reduces gustatory responsiveness to NaCl in the parabrachial nucleus of rats."Neuroscience Letters. 236(1). 33-36 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Yasoshima and T. Yamamoto: "Short-term and long-term excitability changes of the insular cortical neurons after the acquisition of taste aversion learning in behaving rats."Neuroscience. 284(1). 1-5 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Sakai and T. Yamamoto: "Role of the medial and lateral parabrachial nucleus in acquisition and retention of conditioned taste aversion in rats."Behavioural Brain Research. 93(1-2). 63-70 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Ugawa, Y. Minami, W. Guo, Y. Saishin, K. Takatsuji, T. Yamamoto, M. Tohyama and S. Shimada: "Receptors that leaves a sour taste in the mouth."Nature. 395(6702). 555-556 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Sako and T. Yamamoto: "Electrophysiological and behavioral studies on taste effectiveness of alcohols in rats."American Journal of Physiology. 276(2). R388-R396 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Sako and T. Yamamoto: "Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat."Neurosci. Lett. 261(2). 109-112 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Yamada, N. Sako, E. Ando, M. Yamada, H. Kikuzaki and T. Yamamoto: "New bitter diterpenes, rabdosianone I and II, isolated from isodon japonicus hara."Biosci. Biotechnol. Biochem.. 63(3). 524-529 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Sakai and T. Yamamoto: "Possible routes of visceral information in the rat brain in formation of conditioned taste aversion."Neurosci. Res.. 35(1). 53-61 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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