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1998 Fiscal Year Final Research Report Summary

Association of masticatory function with morphology and function of the central nervous system

Research Project

Project/Area Number 09470471
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 矯正・小児・社会系歯学
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

TANNE Kazuo  Hiroshima University School of dentistry, Professor, 歯学部, 教授 (30159032)

Co-Investigator(Kenkyū-buntansha) UEDA Hiroshi  Hiroshima University Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (20304446)
SUGIYAMA Hiroki  Hiroshima University School of Dentistry, Research Associate, 歯学部, 助手 (10294571)
TANAKA Eiji  Hiroshima University Dental Hospital, Assistant Professor, 歯学部・附属病院, 講師 (40273693)
MIYAMOTO Keisuke  Hiroshima University Dental Hospital, Assistant Professor, 歯学部・附属病院, 講師 (40229886)
Project Period (FY) 1997 – 1998
KeywordsMastication / Occlusion / Mechanical stimuli / Sensory input / Central nervous system / Osteopetrotic mice / Masticatory muscle activity
Research Abstract

In recent years, an important role of the tooth and the relevant functions such as biting, chewing and mastication has been addressed. Under such background, the present study was designed to investigate the influences of stomatognathic functions on the development of the other tissues and organs, the central nervous system in particular, by use of rats and mice as experimental animals and human subjects.
In an experiment with osteopetrotic (op/op) mice involved with defects in osteoclastic activity and tooth eruption, the reduced masticatory function produced a decrease in the number of neurons in the central nervous system. Such phenomena were similarly observed in normal mice and rats subjected to artificial reduction in mechanical stimuli from mastication and physical exercise. These findings were eliminated to some extent, approaching the normal controls, by an artificial injection of osteoclast induction agents, which generate tooth eruption and recover in masticatory function. Furthermore, . mechanical stimuli to the teeth in rats induced a specific C-fos protein in the central nervous system. Meanwhile, such association in humans has been studied by use of a portable electromyogram recorder, demonstrating the nature of masticatory function in subjects with occiusal discrepancy. In conclusion, it is emphasized that external mechanical stimuli from stomatognathic functions substantially affect the development of the central nervous system, indicating an important role of the dentition and the related masticatory function.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Kawata,T.et al.: "Morphology of the mandibular condyle in ‘toothless' osteopetrotic (op/op) mice" J.Craniofac.Genet.Devl.Biol.17. 198-203 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河田俊嗣、他: "大理石骨病(op/op)マウスの大腿骨にみる骨組織の成長変化について" 成長. 36. 17-24 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujita,T.et al.: "Influences of ovariectomy and orchiectomy on the remodeling of mandibular condyle in mice" J.Craniofac.Genet.Dev.Biol.18. 164-170 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaku,M.et al.: "Osteoclast appearance in developmental stages of different bines after a single injection of macrophage colony-stimulating factor in op/op mice" Biomed.Res.19. 77-81 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueda,M.H.,et al.: "Relationship between masticatory muscle activity and vertical craniofacial morphology" Angle Orthod.68. 233-238 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawata,T.,et al.: "Midpalatal suture of osteopetrotic (op/op) mice exhibits immature fusion" Exp.Anim.47. 277-281 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawata, T., Niida, S., Kawasoko, S., Kaku, M., Fujita, T., Sugiyama, H., Tanne, K.: "Morphology of the mandibular condyle in 'toothless' osteopetrotic (op/op) mice" J.Craniofac.Genet.Devl.Biol.17. 198-203 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujita, T., Kawata, T., Tokimasa, C., Kaku, M., Kawasoko, S., Tanne, K.: "Influences of ovariectomy and orchiectomy on the remodeling of mandibular condyle in mice" J.Craniofac.Genet.Dev.Biol.18. 164-170 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaku, M., Kawata, T., Kawasoko, S., Fujita, T., Tokimasa, C., Niida, S., Tanne, K.: "Osteoclast appearance in developmental stages of different bones after a single injection of macrophage colony-stimulating factor in op/op mice" Biomed.Res.19. 77-81 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueda, M.H., Ishizuka, Y., Miyamoto, K., Morimoto, N., Tanne, K.: "Relationship between masticatory muscle activity and vertical craniofacial morphology" Angle Orthod. 68. 233-238 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawata, T., Tokimasa, C., Fujita, T., Kawasoko, S., Kaku, M., Sugiyama, H., Tanne, K.: "Midpalatal suture of osteopetroti (op/op) mice exhibits immature fusion" Exp.Anim.47. 277-281 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawata, T., Fujita, T., Tokimasa, C., Kawasoko, S., Kaku, M., Sugiyama, H., Niida, S., Tanne, K.: "Suspension "hypokinesia/hypodynamia" may decrease bone mass by stimulating osteoclast production in Ovariectomized (OVX) mice" J.Nut.Sci, Vitam.44. 581-590 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawata, T., Kawasoko, S., Kaku, M., Fujita, T., Tokimasa, C., Niida, S., Tanne, K.: "Recruitment of osteoclasts in the mandibular condyle of growing osteopetrotic (op/op) mice after a single injection of macrophage colony-stimulating factor (M-CSF)" Archs.Oral Biol.(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaku, M., Kawata, T., Kawasoko, S., Fujita, T., Tokimasa, C.and Tanne, K.: "Remodeling of the sagittal suture in osteopetrotic (op/op) mice associated with cranial flat bone growth" J.Craniofac.Genet.Dev.Biol.(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawata, T., Tokimsas, C., Fujita, T., Kawasoko, S., Sigiyama, H., Ozawa S.and Tanne, K.: "Morphological change of the nasopremaxillary suture in growing "toothless" osteopetrotic (op/op) mouse" J.Craniofac.Genet.Dev.Biol.(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saifuddin, MD., Miyamoto, K., Ueda, H.M., Shikata, N.and Tanne, K.: "A quantitative electromyographic analysis of masticatory muscle activity in usual daily life" J.Oral Disease. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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