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1999 Fiscal Year Final Research Report Summary

MOLECULAR MECHANISUMS OF CARDIOVASCULAR REMODELING

Research Project

Project/Area Number 09470527
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionOSAKA CITY UNIVERSITY MEDICAL SCHOOL

Principal Investigator

IWAO Hiroshi  OSAKA CITY UNIVERSITY MEDICAL SCHOOL, PHARMACOLOGY, PROFESSOR, 医学部, 教授 (00137192)

Co-Investigator(Kenkyū-buntansha) MITSUYAMA Shokei  OSAKA CITY UNIVERSITY MEDICAL SCHOOL, PHARMACOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (10195414)
Project Period (FY) 1997 – 1999
KeywordsRENIN-ANGIOTENSIN SYSTEM / SIGNAL TRANSDUCTION / ORGA DAMAGE / MAP KINASE / CARDLAC HYPERTROPHY / ANGIOTENSIN RECEPTOR ANTAGONIST / CONVERTING ENZYME INHIBITOR
Research Abstract

The renin-angiotensin-aldosterone system (RAAS) plays an important role in both the physiological regulation of blood pressure and in the pathophysiological disruption of cardiovascular organ damages. Angiotensin II (Ang II) is the primary biological mediator of the RAAS. Pathophysiological actions of Ang II is mediated by the angiotensin II type I receptor, for examples of vasoconstriction on vascular smooth muscle, secretion of aldosterone, reabsorption of sodium in the renal proximal nephron, and cell growth and proliferation.
Treatments of RAAS inhibitors, angiotensin converting enzyme and Ang II type I receptor antagonist, in hypertensive rat models caused prevention effects of hypertension, cardiac hypertrophy, and vascular sclerosis and glomerular sclerosis. In addition, these effects were associated with suppressive gene expressions of TGF-b, collagen type I, collagen type II, fibronectin. These gene expression were caused by the stimulation of Ang II type I receptor through the activation of mitogen-activated protein kinases (ERK and JNK). Both angiotensin converting enzyme and Ang II type I receptor antagonist inhibited the activation of ERK and JNK.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] S. Kim et. al.: "Activation of mitogen-activated protein kinases in cardiovascular hypertrophy and remodeling"Jpn. J. Pharmacol.. 80. 97-102 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A. Hamaguchi et . al.: "Contribution of extracellular signal-regulatd kinase to Angiotensin II-induced transforming growth factor-β1 expression in vascular smooth muscle cells"Hypertension. 34. 126-131 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Kim and H. Iwao: "Molecular and cellular mechamisms of Angiotensin II-Mediated cardiovascular and renal diseases"Pharmacological Reviews. 52. 11-34 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kim,S., Sada,T., Mizuno,M., Ikeda,M, Yano,M., Mirua,K., Yamanaka,S., Koike,H., and Iwao,H.: "Effects of angiotensin AT1 receptor antagonist on volume overload- induced cardiac gene expression in rats"Hypertension Research. 20. 133-142 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim,S., Murakami,T., Izumi,Y., Yano,M., Mirua,K., Yamanaka,S. and Iwao,H.: "Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activities are continuously and differentially increased in aorta of hypertensive rats"Biochem, Biophys.Res.Commun.. 236. 199-204 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamaguchi,A., Kim,S., Wanibuchi,H. and Iwao, H.: "Imidapril inhibits increased transforming growth factor- β1 expression in remnant kidney model"European Journal of Pharmacology. 331. 27-30 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim,S., Wnibuchi,H., Hamaguchi,A., Miura,K., Yamanaka,S. and Iwao, H.: "Angiotensin blockade improves cardiac and renal complications of type II diabetic rats"Hypertension. 30. 1054-1061 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Izumi,Y., Kim,S., Murakami,T., Yamanaka,S. and Iwao,H.: "Cardiac mitogen-activated protein kinase activities are chronically increased in Stroke-Prone Hypertensive Rats"Hypertension. 31, part 1. 50-56 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim,S. and Iwao,H.: "Involvement of angiotensin II in cardiovascular and renal injury : effects of an AT1-receptor antagonist on gene expression and the cellular phenotype"J.Hypertension. 15(suppl 6). S3-S7 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamaguchi,A., Kim,S., Yano,M., Yamanaka,S. and Iwao,H.: "Activation of glomerular mitogen-activated protein kinases in angiotensin II-mediated hypertension"J.Am.Soc.Nephrol.. 9. 327-380 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim.S., Izumi,Y., Yano,M., Hamaguchi,A., Miura,K., Yamanaka,S., Miyazaki,H. and Iwao,H.: "Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery"Circulation. 97. 1731-1737 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yano,M., Kim,S., Izumi,Y., Yamanaka,S. and Iwao,H.: "Differential activation of cardiac c-Jun amino-terminal kinase and extracellular signal-regulated kinase in angiotensin II-mediated hypertension"Circulation Research. 83. 752-760 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim,S and Iwao,H.: "Activation of mitogen-activated protein kinases in cardiovascular hypertrophy and remodeling"Jpn.J.Pharmacol.. 80. 97-102 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamaguchi,A., Kim,S., Izumi,Y., Zhan,Y., Yamanaka,S. and Iwao,H.: "Contribution of extracellular signal-regulated kinase to Angiotensin II-induced transforming growth factor-β1 expression in vascular smooth muscle cells"Hypertension. 34. 126-131 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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